ID X0CXG6_FUSOX Unreviewed; 1146 AA.
AC X0CXG6;
DT 14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT 14-MAY-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=FOQG_01611 {ECO:0000313|EMBL:EXK98861.1};
OS Fusarium oxysporum f. sp. raphani 54005.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium oxysporum species complex.
OX NCBI_TaxID=1089458 {ECO:0000313|EMBL:EXK98861.1, ECO:0000313|Proteomes:UP000030663};
RN [1] {ECO:0000313|EMBL:EXK98861.1, ECO:0000313|Proteomes:UP000030663}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=54005 {ECO:0000313|EMBL:EXK98861.1,
RC ECO:0000313|Proteomes:UP000030663};
RG The Broad Institute Genome Sequencing Platform;
RA Ma L.-J., Gale L.R., Schwartz D.C., Zhou S., Corby-Kistler H., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Fusarium oxysporum PHW815.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; JH658363; EXK98861.1; -; Genomic_DNA.
DR AlphaFoldDB; X0CXG6; -.
DR eggNOG; KOG0942; Eukaryota.
DR HOGENOM; CLU_002173_2_4_1; -.
DR Proteomes; UP000030663; Unassembled WGS sequence.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:UniProt.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS50096; IQ; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:EXK98861.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030663};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 774..1146
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1114
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1146 AA; 129064 MW; 59A1E5045F11D863 CRC64;
MFSTFTGNSR RPRNVNLSGT TGNPFTNTSW SPSAVSNTTK TVSNAQAERE KRQADRAKLK
AAGKIQRIWR GYKTRAELKE SQRNAFDALY KSGPRQNPCE RLPKAFGLLL SFFSLRRDDD
IQRAICYAHD TESVDLEAIA PSNVHPSRVG CLVQLLLQAL DKSLSIGDLS GDTHLLFKLV
LRIVTKYPEL VIPAIDSYYT VVAKLCQFQK LSGQWQDVML QAISRPLEAA SHEGTSQVYR
AYAFSFLAKN NLYFFEENIS TLSNAVRLSD LSKAIVTGLS SPSSEKHFQD AQLWQLAHFI
DLSRFNANNS SGSGVLETLY TQLSSLSSTI SVRLLAKSTD GDENSSEEPL VPSLDPYITA
RLMSLVDSNG ISQTLHEFST NLAGSSSQEY QSTSFLAGYI LTLLRCFPAN SDDIRMRLFL
EEIPTISGDV PTIKFLWHIM SETAVFEKLR TESEAPLNVL RRYLGVTSET SNSLEEEQDW
RIALLFLELY IFILRLSDDE DFFSGIDPRI MEQNQSISRI RSCSLSLEDV KMLTSFLKNT
AFTLHYRAQD LSKSADGLEA ASRYRIDTYF GSGQSSAMIS EGPSSPTKSP TRLDIDSLRN
IVTTAMKMLY ERDSRKQFLP TDHWLMTSKL DQSDFISAVI AEEKRQIDEN SDGSDVEGSE
HGDGPGLYST IVGQRLSRHA RLEKLKAQQI RSQRERRLAE MKPKLEILKH MPFAVPFETR
VQIFRHFIQL DRQQRGDNSQ SFFAGPYAKH HAQISRNSLF DDAYKQFYEI GEGLKDPIQI
TFVDQFGTAE AGIDGGGVTK EFLISVTTEA FGAEGGRGMF TSNEKGLLFP DPTALDVIRE
ELRHAGMTEA DSTFRDMISD LLKRYEFLGR IVGKCMYEGI LVDLAFAGFF LLKWTSTGPN
DENTYKGNVN DLRDMDEDLY RGMLRLKNYP GDVSELGIDF TIEDQVSDPK NPVKTVTRKL
IANGDQIHVT NDNRLLYISY VARHRLVVQP APQTSAFLRG LRSIIRPSWL SMFNQSELQR
LVGGDSSEID IEDLRNHTIY SGLYQIGDDG EEHETIKLFW KVMRSFTDDQ RRAVLKYVSS
TPRAPLLGFS QLRPLFSIRD GGTDEERLPS TSTCVNLLKL PRYTSEATLR EKLLYAVQSG
AGFDLS
//
