ID   X0QJM7_9LACO            Unreviewed;       415 AA.
AC   X0QJM7;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=Dihydrothymine dehydrogenase {ECO:0000256|ARBA:ARBA00032722};
DE   AltName: Full=Dihydrouracil dehydrogenase {ECO:0000256|ARBA:ARBA00030119};
GN   ORFNames=FC83_GL001502 {ECO:0000313|EMBL:KRM30371.1};
OS   Agrilactobacillus composti DSM 18527 = JCM 14202.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Agrilactobacillus.
OX   NCBI_TaxID=1423734 {ECO:0000313|EMBL:KRM30371.1, ECO:0000313|Proteomes:UP000051236};
RN   [1] {ECO:0000313|EMBL:KRM30371.1, ECO:0000313|Proteomes:UP000051236}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 18527 {ECO:0000313|EMBL:KRM30371.1,
RC   ECO:0000313|Proteomes:UP000051236};
RX   PubMed=26415554; DOI=10.1038/ncomms9322;
RA   Sun Z., Harris H.M., McCann A., Guo C., Argimon S., Zhang W., Yang X.,
RA   Jeffery I.B., Cooney J.C., Kagawa T.F., Liu W., Song Y., Salvetti E.,
RA   Wrobel A., Rasinkangas P., Parkhill J., Rea M.C., O'Sullivan O., Ritari J.,
RA   Douillard F.P., Paul Ross R., Yang R., Briner A.E., Felis G.E.,
RA   de Vos W.M., Barrangou R., Klaenhammer T.R., Caufield P.W., Cui Y.,
RA   Zhang H., O'Toole P.W.;
RT   "Expanding the biotechnology potential of lactobacilli through comparative
RT   genomics of 213 strains and associated genera.";
RL   Nat. Commun. 6:8322-8322(2015).
CC   -!- SIMILARITY: Belongs to the dihydropyrimidine dehydrogenase family.
CC       {ECO:0000256|ARBA:ARBA00010804}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KRM30371.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AZGA01000088; KRM30371.1; -; Genomic_DNA.
DR   RefSeq; WP_035451341.1; NZ_BAMK01000004.1.
DR   AlphaFoldDB; X0QJM7; -.
DR   STRING; 1423734.FC83_GL001502; -.
DR   PATRIC; fig|1423734.3.peg.1520; -.
DR   eggNOG; COG0167; Bacteria.
DR   eggNOG; COG1146; Bacteria.
DR   OrthoDB; 9794954at2; -.
DR   Proteomes; UP000051236; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro.
DR   CDD; cd02940; DHPD_FMN; 1.
DR   Gene3D; 3.30.70.20; -; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR005720; Dihydroorotate_DH_cat.
DR   PANTHER; PTHR43073; DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]; 1.
DR   PANTHER; PTHR43073:SF2; DIHYDROPYRIMIDINE DEHYDROGENASE [NADP(+)]; 1.
DR   Pfam; PF01180; DHO_dh; 1.
DR   Pfam; PF14697; Fer4_21; 1.
DR   SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR   SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 2.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051236}.
FT   DOMAIN          337..367
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
FT   DOMAIN          371..400
FT                   /note="4Fe-4S ferredoxin-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51379"
SQ   SEQUENCE   415 AA;  45061 MW;  F0F6EF4324F9CC28 CRC64;
     MIKKDLSIDF LGVHFENPFC LSSSPVGNCY DMCAKAYDEG WGGVVFKTIG PADFEIDEVS
     PRFDELTKED TPFVGFKNME QIAEHPLEEN LADLRRLKTA YPNKVLIASI MGTNEQTWEE
     LAGMVAAAGA DMIEMNLSCP QMTSHAMGSD VGANPELCKK YCEAVKRGSK LPMMAKMTPN
     ITDMVIPAKA CMAGGADGIA AINTVKSIAN VDLDRKIGLP IINGKSSISG FSGKAVKPLA
     LRFIQQMRDA EGLENLPISG IGGIETWEDA AEFILLGSST LQVTTAIMQY GYRIIEDLTN
     GLMHYMAEQG VDHLSELVGL ANKNMIPAEK LDRDYKVLPY IDWDKCIGCG RCLISCFDGA
     HQAITWDEAT RRPTVDPERC VGCHLCKLVC PVDAISAGEV VMKAGRVGTA ASKEI
//