ID   X1DSG2_9ZZZZ            Unreviewed;       187 AA.
AC   X1DSG2;
DT   14-MAY-2014, integrated into UniProtKB/TrEMBL.
DT   14-MAY-2014, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=methenyltetrahydrofolate cyclohydrolase {ECO:0000256|ARBA:ARBA00012776};
DE            EC=3.5.4.9 {ECO:0000256|ARBA:ARBA00012776};
DE   Flags: Fragment;
GN   ORFNames=S01H4_53732 {ECO:0000313|EMBL:GAH07914.1};
OS   marine sediment metagenome.
OC   unclassified sequences; metagenomes; ecological metagenomes.
OX   NCBI_TaxID=412755 {ECO:0000313|EMBL:GAH07914.1};
RN   [1] {ECO:0000313|EMBL:GAH07914.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Expedition CK06-06 {ECO:0000313|EMBL:GAH07914.1};
RX   PubMed=24624126; DOI=10.3389/fmicb.2014.00080;
RA   Kawai M., Futagami T., Toyoda A., Takaki Y., Nishi S., Hori S., Arai W.,
RA   Tsubouchi T., Morono Y., Uchiyama I., Ito T., Fujiyama A., Inagaki F.,
RA   Takami H.;
RT   "High frequency of phylogenetically diverse reductive dehalogenase-
RT   homologous genes in deep subseafloor sedimentary metagenomes.";
RL   Front. Microbiol. 5:80-80(2014).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAH07914.1}.
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DR   EMBL; BART01030848; GAH07914.1; -; Genomic_DNA.
DR   AlphaFoldDB; X1DSG2; -.
DR   GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   CDD; cd01080; NAD_bind_m-THF_DH_Cyclohyd; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR000672; THF_DH/CycHdrlase.
DR   InterPro; IPR020867; THF_DH/CycHdrlase_CS.
DR   InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR   PANTHER; PTHR48099:SF5; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC; 1.
DR   PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR   Pfam; PF02882; THF_DHG_CYH_C; 1.
DR   PRINTS; PR00085; THFDHDRGNASE.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00767; THF_DHG_CYH_2; 1.
PE   4: Predicted;
FT   DOMAIN          27..183
FT                   /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT                   NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02882"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:GAH07914.1"
SQ   SEQUENCE   187 AA;  20511 MW;  3269C51E5D984F06 CRC64;
     VPDKLRNSTS RILEYIDTEK DVDGLNPLTK GKLFNYDEEL APCTAKGIIK LLEYNEINLK
     GKDIVIINRS NLVGKPLIFM LLKRNATVSI CHTSTINIDS YIQKADILIV AVGKPGFITA
     EKIKNGVVII DVGITRIESK LYGDVDYNGV LYKCGKITPV PGGIGPMTVA MLCANTINAY
     KNQLNVL
//