ID X2DEK8_9PLVG Unreviewed; 664 AA.
AC X2DEK8;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AHL45339.1};
OS Simian-Human immunodeficiency virus.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus;
OC Primate lentivirus group.
OX NCBI_TaxID=57667 {ECO:0000313|EMBL:AHL45339.1};
RN [1] {ECO:0000313|EMBL:AHL45339.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SHIV {ECO:0000313|EMBL:AHL45339.1};
RA Del Prete G.Q., Keele B.F., Hatziioannou T.;
RT "Unpassaged R5-Tropic Founder Env SHIVs for Nonhuman Primate
RT Immunoprophylactic Studies.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; KJ372065; AHL45339.1; -; Other_RNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 1.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 2.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:AHL45339.1};
KW Virion {ECO:0000313|EMBL:AHL45339.1}.
FT TRANSMEM 460..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 626..653
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..459
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 478..653
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AHL45339.1"
FT NON_TER 664
FT /evidence="ECO:0000313|EMBL:AHL45339.1"
SQ SEQUENCE 664 AA; 74676 MW; 3D6DFFD698532C0F CRC64;
FCASDAKSYD TEVHNVWATH ACVPTDPNPQ EVVMGNVTES FNMWKNHMVE QMHEDIISLW
DQSLKPCVRL TPLCVTLNCS NYAGTNTTAI NTNTTVWGEK MDPGEIKNCS FNIATPIKDK
RHQEYALFYK SDVVPIDEDN DTTSYRLISC NTSVITQACP KVSFEPIPIH YCAPAGFAIL
KCNNKTFNGS GPCTNVSTVQ CTHGIKPVVS TQLLLNGSLA EEEVVIRSAN FTDNAKTIMI
QLKDPVEISC TRPNNNTIKG IHIGPGRAFY TTGQVIGDIR KAYCNISRAK WNHTLSQVVE
KLRLQFQNKT IVFNQSSGGD PEIVMHTFNC GGEFFYCNST PLFNSTWNDT KGSNNTVGND
TIILQCRIKQ IINMWQEVGK AMYAPPIKGN ISCSSNITGL LLTRDGGIVD NNDETFRPGG
GDMRDNWRSE LYKYKVVKIE PLGIAPTKAK RRVVQREKRA IGIGAMFLGF LGAAGSTMGA
ASMTLTVQAR QLLSGIVQQQ NNLLRAIEAQ QHLLQLTVWG VKQLQARVLA VERYLKDQQL
LGIWGCSGKL ICTTTVPWNV SWSNKSLDNI WNEMTWMEWE REIDNYTDII YSLIEESQNQ
QDKNEKELLE LDKWDSLWNW FSITKWLWYI RIFIMIVGGL VGLRIVFAVL SIVNRVRQGY
SPLS
//
