ID X2G3D5_9HEPC Unreviewed; 288 AA.
AC X2G3D5;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=NS3 protein {ECO:0000313|EMBL:AHN12929.1};
DE Flags: Fragment;
OS Hepacivirus hominis.
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
OC Amarillovirales; Flaviviridae; Hepacivirus.
OX NCBI_TaxID=3052230 {ECO:0000313|EMBL:AHN12929.1};
RN [1] {ECO:0000313|EMBL:AHN12929.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=101: Follow Up Week 2 {ECO:0000313|EMBL:AHN12929.1};
RX PubMed=24637689; DOI=10.1128/AAC.02672-13;
RA Tong X., Li L., Haines K., Najera I.;
RT "Identification of the NS5B S282T Resistant Variant and Two Novel Amino
RT Acid Substitutions That Affect Replication Capacity in Hepatitis C Virus-
RT Infected Patients Treated with Mericitabine and Danoprevir.";
RL Antimicrob. Agents Chemother. 58:3105-3114(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|ARBA:ARBA00004328}.
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DR EMBL; KJ530435; AHN12929.1; -; Genomic_RNA.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0044423; C:virion component; IEA:UniProtKB-KW.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0019087; P:transformation of host cell by virus; IEA:InterPro.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR Gene3D; 2.40.10.120; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR004109; HepC_NS3_protease.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR Pfam; PF02907; Peptidase_S29; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51822; HV_PV_NS3_PRO; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Virion {ECO:0000256|ARBA:ARBA00022844};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 1..182
FT /note="Peptidase S29"
FT /evidence="ECO:0000259|PROSITE:PS51822"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AHN12929.1"
FT NON_TER 288
FT /evidence="ECO:0000313|EMBL:AHN12929.1"
SQ SEQUENCE 288 AA; 30031 MW; AD3C8568B2AC11C6 CRC64;
APITAYAQQT RGLLGCIITS LTGRDKNQAE GEVQIVSTAT QTFLATCING ACWTVYHGAG
TRTIASSKGP VIQMYTNVDQ DLVGWPAPQG TRSLXPCTCG SSDLYLVTRH ADVIPVRRRG
DSRGSLLSPR PISYLKGSSG GPLLCPAGHA VGIFKAAVCT RGVAKAVDFI PVENLETTMR
SPVFTDNSSP PAVPQSFQVA HLHAPTGSGK STKVPAAYXA QGYKVLVLNP SVAATLGFGA
YMSKAHGIDA NIRTGVRTIT TGSPITYSTY GKFLADGGCS GGAYDIII
//