ID   X2HCZ5_9NEIS            Unreviewed;       356 AA.
AC   X2HCZ5;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 39.
DE   SubName: Full=Threonine dehydrogenase and related Zn-dependent dehydrogenase {ECO:0000313|EMBL:AHN28942.1};
GN   ORFNames=SALWKB2_1560 {ECO:0000313|EMBL:AHN28942.1};
OS   Snodgrassella alvi wkB2.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Snodgrassella.
OX   NCBI_TaxID=1196094 {ECO:0000313|EMBL:AHN28942.1, ECO:0000313|Proteomes:UP000019668};
RN   [1] {ECO:0000313|EMBL:AHN28942.1, ECO:0000313|Proteomes:UP000019668}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WkB2 {ECO:0000313|EMBL:AHN28942.1};
RX   PubMed=25053814;
RA   Kwong W.K., Engel P., Koch H., Moran N.A.;
RT   "Genomics and host specialization of honey bee and bumble bee gut
RT   symbionts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:11509-11514(2014).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP007446; AHN28942.1; -; Genomic_DNA.
DR   RefSeq; WP_025331133.1; NZ_CP091515.1.
DR   AlphaFoldDB; X2HCZ5; -.
DR   STRING; 1196094.SALWKB2_1560; -.
DR   GeneID; 32536927; -.
DR   KEGG; salv:SALWKB2_1560; -.
DR   PATRIC; fig|1196094.4.peg.1561; -.
DR   HOGENOM; CLU_026673_11_3_4; -.
DR   OrthoDB; 9773078at2; -.
DR   Proteomes; UP000019668; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08286; FDH_like_ADH2; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR42813:SF4; NADP-DEPENDENT ISOPROPANOL DEHYDROGENASE; 1.
DR   PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Zinc {ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          8..354
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   356 AA;  38818 MW;  EE817382DE03A7FF CRC64;
     MKAMVYYGAG DIRFEERTKP VIIEPTDAII RLTRTTICGT DLGIWKGKNP EIEQTAIQKD
     GQFNGRILGH EGIGIIEETG SAVKNFKKGD KVIISCVSRC GTCENCQKQL YAHCQSGGGW
     IMGYMIDGTQ AEYVRTPFAD NSLYRLPANL NEDVAVLLSD ALPTAHEIGV QYGDVKPGDT
     VAIVGAGPVG MSCLLTAQLY SPSQIIMIDM DDNRLHMAKE LGATQIINSA SEDAVARVLE
     YTGGRGVDCA MEAVGLEATW NICQRVVKEG GHLANVGVHG QSVNFELEKL WIKNLTITTG
     LVNANTTGML LKTCCSGKLP MEKLATHHFH FNELEKAYDV FKHAADEKAM KVIIDY
//