ID X2LAS9_AMPMU Unreviewed; 212 AA.
AC X2LAS9;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:AHN97357.1};
OS Amphibolurus muricatus (Jacky dragon) (Lacerta muricata).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Acrodonta; Agamidae; Amphibolurinae; Amphibolurus.
OX NCBI_TaxID=116113 {ECO:0000313|EMBL:AHN97357.1};
RN [1] {ECO:0000313|EMBL:AHN97357.1}
RP NUCLEOTIDE SEQUENCE.
RA Pepper M.R., Barquero M.D., Whiting M.J., Keogh J.S.;
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AHN97357.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24315864; DOI=10.1016/j.ympev.2013.11.012;
RA Pepper M., Barquero M.D., Whiting M.J., Keogh J.S.;
RT "A multi-locus molecular phylogeny for Australia's iconic Jacky Dragon
RT (Agamidae: Amphibolurus muricatus): phylogeographic structure along the
RT Great Dividing Range of south-eastern Australia.";
RL Mol. Phylogenet. Evol. 71:149-156(2014).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|ARBA:ARBA00002323, ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; KF871485; AHN97357.1; -; Genomic_DNA.
DR AlphaFoldDB; X2LAS9; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 113..212
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AHN97357.1"
FT NON_TER 212
FT /evidence="ECO:0000313|EMBL:AHN97357.1"
SQ SEQUENCE 212 AA; 23969 MW; 2BE566E201D34006 CRC64;
PMKEVSLRGQ GSLAYPGLRT QGHLEDLGGP NDATRGLTSL ADTFEHVIEE LLDEQQAIPP
SKENKDADLY SSRVMLSSQV PLEPPLLFLL EEYKNYLDAA NMSMRVRRHS DPARRGELSV
CDSTSEWVTA AEKKTAVDMS GATVTVLEKV PVPKGQLKQY FYETKCNSKG YTKEGCRGID
KRYWNSQCRT TQSYVRALTM DNKKRVGWRF IR
//
