ID X5BXV5_9TELE Unreviewed; 404 AA.
AC X5BXV5;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Inhibin beta A chain {ECO:0000256|ARBA:ARBA00014111};
DE AltName: Full=Activin beta-A chain {ECO:0000256|ARBA:ARBA00032434};
OS tetraploid red crucian carp x Cyprinus carpio.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinoidei intergeneric hybrids.
OX NCBI_TaxID=543561 {ECO:0000313|EMBL:AHW29559.1};
RN [1] {ECO:0000313|EMBL:AHW29559.1}
RP NUCLEOTIDE SEQUENCE.
RA Tao M., Liu S., Song C., Zhang Z., Chen J.;
RT "Differential expression of activin betaA, betaB in sterile triploids and
RT fertile tetraploids.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibins and activins inhibit and activate, respectively, the
CC secretion of follitropin by the pituitary gland. Inhibins/activins are
CC involved in regulating a number of diverse functions such as
CC hypothalamic and pituitary hormone secretion, gonadal hormone
CC secretion, germ cell development and maturation, erythroid
CC differentiation, insulin secretion, nerve cell survival, embryonic
CC axial development or bone growth, depending on their subunit
CC composition. Inhibins appear to oppose the functions of activins.
CC {ECO:0000256|ARBA:ARBA00002588}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; KJ174525; AHW29559.1; -; mRNA.
DR AlphaFoldDB; X5BXV5; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR CDD; cd19404; TGF_beta_INHBA; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR000491; Inhibin_betaA.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF133; INHIBIN BETA A CHAIN; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00670; INHIBINBA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354}; Hormone {ECO:0000256|ARBA:ARBA00022702};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..404
FT /note="Inhibin beta A chain"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004954416"
FT DOMAIN 282..404
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 404 AA; 44402 MW; 61F882D98DDFB066 CRC64;
MSSLTLVTGV LLLSGCWSGG CSPTPAESGS QGAGRPDDPV TLCPSCALAQ KQKDSEEQTD
MVEAVKRHIL NMLHLNTRPN VTHPVPRAAL LNAIRKLHVG RVGEDGTVEM EEDGGGLGEH
REQPEEQPFE IITFAEPGDA PDIMRFDISK EGSPLSVVEQ ANVWLFLKVA KGSRGKGKVS
VQLLQYGKAD PGSADGPQEV VVSEKTVDTR RSGWHTLPVP RTVQTLLDGD SSLLSLHVSC
PMCAEAGAVP ILVPAEGNKV KEREQSHRPF LMVVLKPAEE HQHRRSKRGL ECDGKIRVCC
KRQFYVNFKD IGWSDWIIAP SGYHANYCEG DCPSHVASIT GSALSFHSTV INHYRMRGYS
PFNNIKSCCV PTRLRAMSML YYNEEQKIIK RDIQNMIVEE CGCS
//
