ID X6M3R3_RETFI Unreviewed; 1076 AA.
AC X6M3R3;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 22-FEB-2023, entry version 33.
DE SubName: Full=DNA repair protein {ECO:0000313|EMBL:ETO07665.1};
GN ORFNames=RFI_29726 {ECO:0000313|EMBL:ETO07665.1};
OS Reticulomyxa filosa.
OC Eukaryota; Sar; Rhizaria; Retaria; Foraminifera; Monothalamids;
OC Reticulomyxidae; Reticulomyxa.
OX NCBI_TaxID=46433 {ECO:0000313|EMBL:ETO07665.1, ECO:0000313|Proteomes:UP000023152};
RN [1] {ECO:0000313|EMBL:ETO07665.1, ECO:0000313|Proteomes:UP000023152}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24332546;
RA Glockner G., Hulsmann N., Schleicher M., Noegel A.A., Eichinger L.,
RA Gallinger C., Pawlowski J., Sierra R., Euteneuer U., Pillet L.,
RA Moustafa A., Platzer M., Groth M., Szafranski K., Schliwa M.;
RT "The Genome of the Foraminiferan Reticulomyxa filosa.";
RL Curr. Biol. 0:0-0(2013).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETO07665.1}.
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DR EMBL; ASPP01025887; ETO07665.1; -; Genomic_DNA.
DR AlphaFoldDB; X6M3R3; -.
DR EnsemblProtists; ETO07665; ETO07665; RFI_29726.
DR OMA; TPMMAQY; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000023152; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756};
KW Reference proteome {ECO:0000313|Proteomes:UP000023152}.
FT DOMAIN 978..994
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..86
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..156
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1076 AA; 124699 MW; 236EA816F87E1E03 CRC64;
MNQRTLFSLW SLTPKKGDSV PKTPETAKAS TKTTKLETKA IIEEEERKGT AKKTEREKTP
KKAKTKSAKK TQTNVKKKLI FKKAGKKRSR KEVEEEEEME GEEGQPALKK RRLVIKESDE
EDNDKENKDW NELGQGEEEQ EEEKEKEEEE EEDNKNEEKA VDTLNDIDKF GCGKTLIKRE
EKEKNKKTKK DNEDIKEEVN NVRNKEWYKN PREEGYNPKT LLVPKRDLDE LTPAKNGKFY
ELFYMDAELG NEICGLEMIK GKKEAMPHVG FPENSFAKYA DAFVNYGHKV YRIEQMETPE
EAKKRINKST ALLHVMKIII NDCYLLGICE QKQEQKKYDN NNILISICFV DVTIGQFYIG
SFRDDRNRTN LRTLLVQIRP TEIVYNKNET SLETLKMLKT ESRDAFYVSL TEAVDGGQIW
NSIQIRQELM NNKLYWKDKT NMPTILQNIW NDDMQIQCIG NIILYLKSLL LDTQIIPNSE
WKVYDNSDNS ICHYMSLDGA TITNLEILCN EDGNTKGTLF SFLNKCQTAF GQRRLKEWII
SPLKDIVMIN ERLDCVEFLI KQITIFEETR QENNFIQQIS LKLKSLPDLM RLLARISALG
TNRIMDKAVM FDDAWKTRKV KTFCQCLDGL ETAFNIFDLF ESNNHLFKNI KLLNQLMILG
DDLIKLKKQL NYFKNGFDIT EAKSTGFIRP KSDINKEYDN CLIEQQECYN ELDKILRHYQ
NEYKDKNIKY QTQKGKNRSF QLEFSKSKIK NINIPESWQQ VASTTKVVRY RIPEVIKYTD
LLNQLKEKEE MLLRDSARII FADFAQYSTM WRKVVNNLAD LDCLLSLSYV SYYTSFEMSK
PIFIDLKDSP NNKPFLELRQ ARHPCLIDTE NISYNNSNHG SQYIPNDTIL GCEENSSNFI
IVTGPNMGGK STLLRQTCIC MILAHIGCFV PSSLCRLTPI DRIFTRVGAN DRILMGQSTF
MVELEETSNI LRHATSNSLV ILDELGRGTS TFDGTAIAQS VAQYLIDVIQ CRSLFSTHYH
GICDAFIHNP AVAMYHMSFA KQDNLITFLY HFTKGICKES HGIHCARLAG LQVLYL
//
