ID X6M5R7_RETFI Unreviewed; 487 AA.
AC X6M5R7;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=N-terminal Ras-GEF domain-containing protein {ECO:0000259|PROSITE:PS50212};
DE Flags: Fragment;
GN ORFNames=RFI_28054 {ECO:0000313|EMBL:ETO09333.1};
OS Reticulomyxa filosa.
OC Eukaryota; Sar; Rhizaria; Retaria; Foraminifera; Monothalamids;
OC Reticulomyxidae; Reticulomyxa.
OX NCBI_TaxID=46433 {ECO:0000313|EMBL:ETO09333.1, ECO:0000313|Proteomes:UP000023152};
RN [1] {ECO:0000313|EMBL:ETO09333.1, ECO:0000313|Proteomes:UP000023152}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24332546;
RA Glockner G., Hulsmann N., Schleicher M., Noegel A.A., Eichinger L.,
RA Gallinger C., Pawlowski J., Sierra R., Euteneuer U., Pillet L.,
RA Moustafa A., Platzer M., Groth M., Szafranski K., Schliwa M.;
RT "The Genome of the Foraminiferan Reticulomyxa filosa.";
RL Curr. Biol. 0:0-0(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETO09333.1}.
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DR EMBL; ASPP01024136; ETO09333.1; -; Genomic_DNA.
DR AlphaFoldDB; X6M5R7; -.
DR EnsemblProtists; ETO09333; ETO09333; RFI_28054.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000023152; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113:SF369; CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00135};
KW Reference proteome {ECO:0000313|Proteomes:UP000023152}.
FT DOMAIN 242..410
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT REGION 94..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 487
FT /evidence="ECO:0000313|EMBL:ETO09333.1"
SQ SEQUENCE 487 AA; 56048 MW; A1ACE6415E1E8E0B CRC64;
MLITRQNVYP SQKKKFRLMK YEGIDEYLQL LGYEPDSNSS FWICPDDQPP LSVIASAVQV
CNEYIVQCTK RRHAVEAIKM FSVDFRRTQL KSPKNKKIKK KKKFPVNDDK SVRDRTFTEV
PSSGLAISAT GTVKSNTEPT VQSSKSSQQA PPQITPSHTP ENTVDLVLLI FFFFFLDVYT
QEKEVLVLPS LPDDDDVTKT GPGDNEWNVP DLPEPSVAST PTPSTPTRSN ADPEGSNFED
DLEAEQDRFQ LSELIWGITH EDNKDDSAKD VLLLCHQSFC TSMELWQCLA KRFLNRNLSR
GSMSFSLSRN EDPPFYAGEE PVQEEPQKKN KDKKIIEIDA SWSVQVKVTS LLQHWMRLYW
EEDFATQPDL IRSVSKFIEL VDYNVNNDDR FDEEARKKNK KLLQMIQQTI ETQDKQHQKK
AFERESRIIF SKAKSVKMLG MDQDAQQLLQ GFVKINNGQF AEQLTLLDFE LFKLIKPREC
IGQVCLF
//