ID   X6N0S6_RETFI            Unreviewed;       653 AA.
AC   X6N0S6;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=Glycoside hydrolase family 38 central domain-containing protein {ECO:0000259|SMART:SM00872};
DE   Flags: Fragment;
GN   ORFNames=RFI_17727 {ECO:0000313|EMBL:ETO19503.1};
OS   Reticulomyxa filosa.
OC   Eukaryota; Sar; Rhizaria; Retaria; Foraminifera; Monothalamids;
OC   Reticulomyxidae; Reticulomyxa.
OX   NCBI_TaxID=46433 {ECO:0000313|EMBL:ETO19503.1, ECO:0000313|Proteomes:UP000023152};
RN   [1] {ECO:0000313|EMBL:ETO19503.1, ECO:0000313|Proteomes:UP000023152}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24332546;
RA   Glockner G., Hulsmann N., Schleicher M., Noegel A.A., Eichinger L.,
RA   Gallinger C., Pawlowski J., Sierra R., Euteneuer U., Pillet L.,
RA   Moustafa A., Platzer M., Groth M., Szafranski K., Schliwa M.;
RT   "The Genome of the Foraminiferan Reticulomyxa filosa.";
RL   Curr. Biol. 0:0-0(2013).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETO19503.1}.
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DR   EMBL; ASPP01013607; ETO19503.1; -; Genomic_DNA.
DR   AlphaFoldDB; X6N0S6; -.
DR   EnsemblProtists; ETO19503; ETO19503; RFI_17727.
DR   OrthoDB; 5474711at2759; -.
DR   Proteomes; UP000023152; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 2.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR   PANTHER; PTHR11607:SF3; LYSOSOMAL ALPHA-MANNOSIDASE; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000023152};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   TRANSMEM        624..642
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          225..297
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ETO19503.1"
FT   NON_TER         653
FT                   /evidence="ECO:0000313|EMBL:ETO19503.1"
SQ   SEQUENCE   653 AA;  74778 MW;  40AAF8345120DA5A CRC64;
     ACPTLSSIAR QMTDGQQFIL GEFGNDGRPS VAWHVDPFGH SYVTGGLWSQ VGFDAFAMHR
     INYRELNQRK LDKNLEFVWK GSSSLGEDGY IWVHLLDSAY RAPSQIFFFG GSQASYIQTD
     PRLPSYPVNY VELAESFISD TRTKSSWFRH EHILIPFGAD FAHQNAYESM NQMDKLIKYV
     NSNATYNATM IYSTLAEYVS VVNALNLSWN LETNDFYPYA DMAHSWWTGY FTSRPQLKQY
     VRSRENVLRP AEQCVFNETE IMNNITYLRH ALDSAQHHDA VSGTATQNTT NDYMYMLQQG
     TLKVIPFTEQ VAPYFLKKGS NIPTLVRDES LISSLTSDNV LVVVLYNSLG WNVTEVIEVP
     SNVSNIVVFD ALGQQVLSQV NPVAPYAQSF DAAPSQFVVL FLAQLPPLSF TTYFIALRND
     SRLAKTYRVR DVPSHSIGNG YYTLNFTTNP QTNGMFLSGL YNYDADMYFA LNNTWLQYMP
     TGGTYSDGLQ VGCLNVYMRL FFLFVELPTN LLLAQNSGAY VFRPAQDNRY TLSSSQESEM
     TMNNLMFRTW IAPGSSLAFL VATHGESQYN DTFIATVCGY SLEMNQFEYR YYRIDNQSWA
     QNPSFDFLVL NLNASQQSVH FRPAQSTVAY LFFFIFYFLF YVKKKKYIYI YIY
//