ID   X6NNE7_RETFI            Unreviewed;       879 AA.
AC   X6NNE7;
DT   11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT   11-JUN-2014, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
DE   Flags: Fragment;
GN   ORFNames=RFI_09893 {ECO:0000313|EMBL:ETO27244.1};
OS   Reticulomyxa filosa.
OC   Eukaryota; Sar; Rhizaria; Retaria; Foraminifera; Monothalamids;
OC   Reticulomyxidae; Reticulomyxa.
OX   NCBI_TaxID=46433 {ECO:0000313|EMBL:ETO27244.1, ECO:0000313|Proteomes:UP000023152};
RN   [1] {ECO:0000313|EMBL:ETO27244.1, ECO:0000313|Proteomes:UP000023152}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24332546;
RA   Glockner G., Hulsmann N., Schleicher M., Noegel A.A., Eichinger L.,
RA   Gallinger C., Pawlowski J., Sierra R., Euteneuer U., Pillet L.,
RA   Moustafa A., Platzer M., Groth M., Szafranski K., Schliwa M.;
RT   "The Genome of the Foraminiferan Reticulomyxa filosa.";
RL   Curr. Biol. 0:0-0(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETO27244.1}.
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DR   EMBL; ASPP01007377; ETO27244.1; -; Genomic_DNA.
DR   AlphaFoldDB; X6NNE7; -.
DR   EnsemblProtists; ETO27244; ETO27244; RFI_09893.
DR   OrthoDB; 5480623at2759; -.
DR   Proteomes; UP000023152; Unassembled WGS sequence.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00159; RhoGAP; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR044785; RopGAP1-5.
DR   PANTHER; PTHR23177; MKIAA1688 PROTEIN; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000023152}.
FT   DOMAIN          672..853
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          1..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          217..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          280..407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          428..566
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          598..666
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..45
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..72
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        84..128
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        221..242
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..304
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        335..397
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        450..476
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        477..506
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        507..538
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        598..628
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        629..666
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ETO27244.1"
SQ   SEQUENCE   879 AA;  96497 MW;  6FEEED1C47739F59 CRC64;
     KEKEKEKEKE DNDDAISSAN NKDLTPSAAP LAIVNESSIP TGTNENEKAS KDDANVDGNE
     NEDEDDEHAD GEHADDEYAN DENTNNENRN GNENRNGNEN RNGNENRNGN GNESVKQNNS
     NDSGTNPYLF RAKTREKKTF VPYSKVKQVS TESLTLDTKW VNTAPLEPPA DDTKTNERQS
     KRISRVPFSV HLSRNNDETI RGLKKIANVY KDKMASKTRL TQQDRNESVL ISPSSNVSAS
     QRNNITPSFK QVQDEQPQFH ASTSSVSASA SASASVSAIV SPSGSAIPTP SSKVDISESG
     DPNRAQNAGH MRDRTASAFV PRSQAPLRPL PISGNMSKRH SSPNADQKPD LSPTSPAEDS
     VAATVDSNSA STPFTKVHQG QNNVAAANSS LGPSSSDASR ERTRRGHTIA VSSGAALDVD
     RYAHPRARTP SQLGQFTDIV PPPPPPSSSD TNANVNATLP TAERQTRSFT AVQPKTDTSA
     KKKEIKSAWD TDHSNNASEN EYENSEEKAV YNNSTSGPNG EPSQSFASDF SKNNPPPEKG
     RSKSLYALPQ DDSTEKKARP KKKQKKTHFT LLNINIHTLY IHIYIYIINH SKKKEDKGNA
     EAVTESAENS EDEKNNEGND KTDERELSNG NTNNKANTDV YASNSGNGNN NSGNKNTTNN
     NNANDSTKQF GVAIDAVPAT DIPYYDSPIP TILVNLGTSL FENQGHLVEG IFRKLPNQGQ
     YDRVRDTIDS GKTDPSVFQS VDPFIVSQLI KQWLRELPTP LLQSLTVQVI EQTQSDQKFS
     AVFQTIPEPN KSVFLWLLDL CAEIVANQSF NQMNTQSLGA AIGPNLYDMK IIQNPMKAMT
     FLAKLTSFTK IGIEWRMQSR KMTRKNIYKK IYTTFEVAL
//