ID X8AEB1_MYCXE Unreviewed; 413 AA.
AC X8AEB1;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Putative cystathionine beta-synthase {ECO:0000313|EMBL:EUA29849.1};
GN ORFNames=I553_4102 {ECO:0000313|EMBL:EUA29849.1};
OS Mycobacterium xenopi 4042.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1299334 {ECO:0000313|EMBL:EUA29849.1};
RN [1] {ECO:0000313|EMBL:EUA29849.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4042 {ECO:0000313|EMBL:EUA29849.1};
RA Brown-Elliot B., Wallace R., Lenaerts A., Ordway D., DeGroote M.A.,
RA Parker T., Sizemore C., Tallon L.J., Sadzewicz L.K., Sengamalay N.,
RA Fraser C.M., Hine E., Shefchek K.A., Das S.P., Tettelin H.;
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the cysteine synthase/cystathionine beta-
CC synthase family. {ECO:0000256|ARBA:ARBA00007103}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUA29849.1}.
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DR EMBL; JAOB01000060; EUA29849.1; -; Genomic_DNA.
DR AlphaFoldDB; X8AEB1; -.
DR PATRIC; fig|1299334.3.peg.5794; -.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0019344; P:cysteine biosynthetic process; IEA:UniProt.
DR CDD; cd04608; CBS_pair_CBS; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR046353; CBS_C.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR PANTHER; PTHR10314; CYSTATHIONINE BETA-SYNTHASE; 1.
DR PANTHER; PTHR10314:SF194; CYSTATHIONINE BETA-SYNTHASE; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00291; PALP; 2.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898}.
FT DOMAIN 289..351
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 413 AA; 43430 MW; 7845D0D812A5EC6E CRC64;
MIDAAEASGQ LKPGGTIVEP TSGNTGVALA MVAQQRGYKC VFVCPDKVSE DKQNVLRAYG
PKSWCARRRC HPTTRTATTA CPTGWSPRST APGSRTSTRI PTGRQAITRR LDRKSGPTPT
AGSHTSWPGS APADDYGRGP LPQGGVRGAV RVIGADPEGS VYSGGTGRPY LVEGVGEDFW
PAAYDPTVPD EVIAVSDADS FEMTRRLARE EAMLVGGSCG MAVVAALKVA EDAGPDALIV
VLLPDGGRGY MSKIFNDAWM SSYGFLRSRL DGSMQQPTVG DVLRGKSGAL PDLVHTHPSE
TVRDAIGILR EYGVSQMPVV GAEPPVMAGE VVGSVSEREL LSAVFEGRAK LADAVSLHMS
PPLPMIGAGE LITAAAKALR DADALMVVEE GKPVGVITRH DLLGFLSEGP RRR
//
