ID X8GV10_9FIRM Unreviewed; 699 AA.
AC X8GV10;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Phosphoenolpyruvate-dependent sugar PTS family porter, EIIA 2 component {ECO:0000313|EMBL:EUB14793.1};
GN ORFNames=HMPREF1508_0275 {ECO:0000313|EMBL:EUB14793.1};
OS Shuttleworthia sp. MSX8B.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Shuttleworthia.
OX NCBI_TaxID=936574 {ECO:0000313|EMBL:EUB14793.1, ECO:0000313|Proteomes:UP000021619};
RN [1] {ECO:0000313|EMBL:EUB14793.1, ECO:0000313|Proteomes:UP000021619}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSX8B {ECO:0000313|EMBL:EUB14793.1,
RC ECO:0000313|Proteomes:UP000021619};
RA Durkin A.S., McCorrison J., Torralba M., Gillis M., Haft D.H., Methe B.,
RA Sutton G., Nelson K.E.;
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EUB14793.1}.
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DR EMBL; JAQT01000021; EUB14793.1; -; Genomic_DNA.
DR RefSeq; WP_044960202.1; NZ_JAQT01000021.1.
DR AlphaFoldDB; X8GV10; -.
DR PATRIC; fig|936574.3.peg.1102; -.
DR eggNOG; COG1299; Bacteria.
DR eggNOG; COG1445; Bacteria.
DR eggNOG; COG1762; Bacteria.
DR OrthoDB; 9782569at2; -.
DR Proteomes; UP000021619; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005351; F:carbohydrate:proton symporter activity; IEA:InterPro.
DR GO; GO:0022877; F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity; IEA:InterPro.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR CDD; cd00211; PTS_IIA_fru; 1.
DR CDD; cd05569; PTS_IIB_fructose; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR InterPro; IPR002178; PTS_EIIA_type-2_dom.
DR InterPro; IPR036095; PTS_EIIB-like_sf.
DR InterPro; IPR013011; PTS_EIIB_2.
DR InterPro; IPR003501; PTS_EIIB_2/3.
DR InterPro; IPR003352; PTS_EIIC.
DR InterPro; IPR013014; PTS_EIIC_2.
DR InterPro; IPR004715; PTS_IIA_fruc.
DR InterPro; IPR003353; PTS_IIB_fruc.
DR InterPro; IPR006327; PTS_IIC_fruc.
DR NCBIfam; TIGR00829; FRU; 1.
DR NCBIfam; TIGR00848; fruA; 1.
DR NCBIfam; TIGR01427; PTS_IIC_fructo; 1.
DR PANTHER; PTHR30505; FRUCTOSE-LIKE PERMEASE; 1.
DR PANTHER; PTHR30505:SF28; PTS SYSTEM 2-O-ALPHA-MANNOSYL-D-GLYCERATE-SPECIFIC EIIABC COMPONENT; 1.
DR Pfam; PF00359; PTS_EIIA_2; 1.
DR Pfam; PF02378; PTS_EIIC; 1.
DR Pfam; PF02302; PTS_IIB; 1.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
DR SUPFAM; SSF52794; PTS system IIB component-like; 1.
DR PROSITE; PS51094; PTS_EIIA_TYPE_2; 1.
DR PROSITE; PS00372; PTS_EIIA_TYPE_2_HIS; 1.
DR PROSITE; PS51099; PTS_EIIB_TYPE_2; 1.
DR PROSITE; PS51104; PTS_EIIC_TYPE_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683};
KW Pyruvate {ECO:0000313|EMBL:EUB14793.1};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 321..343
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 392..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..459
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..502
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 508..529
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 569..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 609..628
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 640..666
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 673..693
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..149
FT /note="PTS EIIA type-2"
FT /evidence="ECO:0000259|PROSITE:PS51094"
FT DOMAIN 182..277
FT /note="PTS EIIB type-2"
FT /evidence="ECO:0000259|PROSITE:PS51099"
FT DOMAIN 307..699
FT /note="PTS EIIC type-2"
FT /evidence="ECO:0000259|PROSITE:PS51104"
FT REGION 156..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 699 AA; 72596 MW; 2EFD4AA965F01E1B CRC64;
MRVRDLLAPQ SVELNGAPAN KKEAIEQMVA LMEKRGNIRD IDTYRTGVFA REEEGTTGVG
EGIAIPHCKS DAVSAPGLAA MVVPGGVDYE ALDDEPVDLI FLIAAPNTKD NVHLEVLSNL
SMLLMDEDFT RALKAAKSPE EFLDIIEKAE NAKAQKEAAK EAAREEASDE QANGAGSDKG
YVIAVTACPT GIAHTYMAAE AIEKAGEKLG IPVKVETRGS SGPKNILTAE DIQRAAGVVV
ACDAKVPMDR FDGKHLIECK VADGIHKAEE LVTRASVSDA PIYHASGDGG EEEDDKDKET
DSIGHQAYTH LMSGVSHMLP FVIGGGIMVA LAFLIDTIAG YGASAGSAST GSAFGTMLPL
SAFFKYAGGL AMSMMVPVLA GYIAYSIADR PGLAVGFTGG LLATSGNALF ASYNWTNLGA
FNSFIANFAF QGANGGSTVS GFLGGIAAGF VAGFVVLWLK KLTSKLPASL DGIRPTLIYP
LGGIFIISLL MCFIFNPLIG LINAGLSSML TALADANLLV VMGLILGGMM AIDMGGPINK
AAYVFGTGML STAAELMDKG ASATDPAVIA CYVAMAAVMA GGMVPPIGIA LATIFFPRKF
SKTQRDTKVS LFVMGASFIT EAAIPFAAAD PLHTIPATLV GSAIAGGLSA LFGCTLMAPH
GGIFVFATVG NPLFYIIAWF VGSIVTCLLL GLLKKNAEE
//
