ID XPO2_DROME Reviewed; 975 AA.
AC Q9XZU1; Q9UB14; Q9VJH4;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 2.
DT 24-JAN-2024, entry version 158.
DE RecName: Full=Exportin-2;
DE Short=Exp2;
DE AltName: Full=Cellular apoptosis susceptibility protein homolog;
DE AltName: Full=Chromosome segregation protein 1;
DE AltName: Full=Importin-alpha re-exporter {ECO:0000305};
GN Name=Cse1 {ECO:0000312|FlyBase:FBgn0022213};
GN Synonyms=Cas {ECO:0000303|PubMed:11944946};
GN ORFNames=CG13281 {ECO:0000312|FlyBase:FBgn0022213};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11944946; DOI=10.1006/dbio.2002.0612;
RA Tekotte H., Berdnik D., Toeroek T., Buszczak M., Jones L.M., Cooley L.,
RA Knoblich J.A., Davis I.;
RT "Dcas is required for importin-alpha3 nuclear export and mechano-sensory
RT organ cell fate specification in Drosophila.";
RL Dev. Biol. 244:396-406(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=10731138; DOI=10.1126/science.287.5461.2222;
RA Rubin G.M., Hong L., Brokstein P., Evans-Holm M., Frise E., Stapleton M.,
RA Harvey D.A.;
RT "A Drosophila complementary DNA resource.";
RL Science 287:2222-2224(2000).
CC -!- FUNCTION: Export receptor for importin alpha. Mediates importin-alpha
CC re-export from the nucleus to the cytoplasm after import substrates
CC have been released into the nucleoplasm (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds with high affinity to importin-alpha only in the
CC presence of RanGTP. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the XPO2/CSE1 family. {ECO:0000305}.
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DR EMBL; AJ238857; CAB42967.1; -; mRNA.
DR EMBL; AE014134; AAF53575.1; -; Genomic_DNA.
DR EMBL; AF132562; AAD27861.1; -; mRNA.
DR RefSeq; NP_523588.2; NM_078864.3.
DR AlphaFoldDB; Q9XZU1; -.
DR SMR; Q9XZU1; -.
DR BioGRID; 61019; 12.
DR IntAct; Q9XZU1; 6.
DR MINT; Q9XZU1; -.
DR STRING; 7227.FBpp0080484; -.
DR PaxDb; 7227-FBpp0080484; -.
DR EnsemblMetazoa; FBtr0080930; FBpp0080484; FBgn0022213.
DR GeneID; 35016; -.
DR KEGG; dme:Dmel_CG13281; -.
DR AGR; FB:FBgn0022213; -.
DR CTD; 35016; -.
DR FlyBase; FBgn0022213; Cse1.
DR VEuPathDB; VectorBase:FBgn0022213; -.
DR eggNOG; KOG1992; Eukaryota.
DR GeneTree; ENSGT00550000074884; -.
DR HOGENOM; CLU_009614_0_0_1; -.
DR InParanoid; Q9XZU1; -.
DR OrthoDB; 178772at2759; -.
DR PhylomeDB; Q9XZU1; -.
DR SignaLink; Q9XZU1; -.
DR ChiTaRS; caz; fly.
DR GenomeRNAi; 35016; -.
DR PRO; PR:Q9XZU1; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0022213; Expressed in eye disc (Drosophila) and 24 other cell types or tissues.
DR Genevisible; Q9XZU1; DM.
DR GO; GO:0005829; C:cytosol; HDA:FlyBase.
DR GO; GO:0005635; C:nuclear envelope; HDA:FlyBase.
DR GO; GO:0005654; C:nucleoplasm; HDA:FlyBase.
DR GO; GO:0005049; F:nuclear export signal receptor activity; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006611; P:protein export from nucleus; IMP:FlyBase.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR005043; XPO2_C.
DR InterPro; IPR013713; XPO2_central.
DR PANTHER; PTHR10997:SF8; EXPORTIN-2; 1.
DR PANTHER; PTHR10997; IMPORTIN-7, 8, 11; 1.
DR Pfam; PF03378; CAS_CSE1; 1.
DR Pfam; PF08506; Cse1; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT CHAIN 1..975
FT /note="Exportin-2"
FT /id="PRO_0000117290"
FT DOMAIN 29..105
FT /note="Importin N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
FT CONFLICT 194
FT /note="K -> T (in Ref. 2; AAF53575)"
FT /evidence="ECO:0000305"
FT CONFLICT 331
FT /note="Q -> P (in Ref. 1; CAB42967)"
FT /evidence="ECO:0000305"
FT CONFLICT 589..590
FT /note="AA -> GR (in Ref. 1; CAB42967)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 975 AA; 110168 MW; 5C9BA11C08D49C11 CRC64;
MEVTEANLQL LAGYLQQTLS ADPNVRRPAE KLLESTELQQ NYPILLLNLI DKAQMDMTTR
VAGAIAFKNY IKRNWAAHLD SDGPDRIHES DRNTIKTLIV TLMLHSPVAL QKQLSDAVSI
IGKYDFPKKW PQLIDEMVER FASGDFNVIN GVLQTAHSLF KRYRYEFKSQ ALWEEIKFVL
DRMAKPLTDL LQAKMQLTKV HENNAGALKV IYGSLVLVNK VFFSLNSQDL PEFFEDNINT
WMGAFIQQLA ADVPSLRTAD DEDAGVLEHL RAQVCENICL YAKKYDEEFK PFMEQFVTAV
WELLVKTSLH TKYDSLVSHA LQFLSVVADR QHYQSIFENP EILAQICDKV VIPNLDIRPS
DEEIFEDSPE EYIRRDIEGS DIDTRRRAAC DLVKTLSINF EQKIFGIFGQ YLERLLTKYK
ENPATNWRSK DTAIYLVTSW ASRGGTQKHG ITQTSELVPL PEFCAQQIIP ELERPNINEF
PVLKAAAIKY VMVFRSILGP QVLASCLPQL IRHLPAESSV VHSYAACSVE KILSMRDASN
AIVFGPQILA PYTTELISGL FATLSLPGSG ENEYVMKAIM RSFSVLQSAA MPFMGVALPR
LTEILTQVAK NPSRPQFNHY LFETLALCIK IVCHADSSAV SSFEEALFPV FQGILQQDIV
EFMPYVFQML SVLLEMREGT GTIPEPYWAL FPCLLSPALW DRTGNVTPLI RLISAFIKQG
SAQIQALGKL SGILGIFQKM IASKANDHEG FYLLQNLLSY YPPAEIQTNL RQIFGLLFQR
LSLSKTPKYL SGIIIFFSFY VIKFSGSQMA QLIDEIQPNL FGMLLDRVFI TEMGKIPKEQ
DRKMVAVGVT KLLTETPEIL QQQYATFWPR LLHSLIDLFE RPPEKLMGLE IGETAGVAED
PDAGYQVAFA QLTHAQPNQQ DHLAEIKDAR QFLATSLSKF AQARAGEFST LLSPLEPEYK
QVLQKYCDQA GVRIA
//
