ID Y1533_MYCBO Reviewed; 336 AA.
AC P63578; A0A1R3XYX5; P71777; X2BI73;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 25-MAY-2022, sequence version 2.
DT 24-JAN-2024, entry version 98.
DE RecName: Full=Probable GTPase Mb1533;
DE EC=3.6.-.-;
GN OrderedLocusNames=BQ2027_MB1533;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
CC -!- FUNCTION: Probable GTPase. May also bind and hydrolyze ATP. May
CC function as chaperone (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=SIU00136.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000250|UniProtKB:P9WPZ1};
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DR EMBL; LT708304; SIU00136.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_855185.1; NC_002945.3.
DR AlphaFoldDB; P63578; -.
DR SMR; P63578; -.
DR PATRIC; fig|233413.5.peg.1675; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd03114; MMAA-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR005129; GTPase_ArgK.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00750; lao; 1.
DR PANTHER; PTHR23408:SF3; METHYLMALONIC ACIDURIA TYPE A PROTEIN, MITOCHONDRIAL; 1.
DR PANTHER; PTHR23408; METHYLMALONYL-COA MUTASE; 1.
DR Pfam; PF03308; MeaB; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding; Chaperone; GTP-binding; Hydrolase; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..336
FT /note="Probable GTPase Mb1533"
FT /id="PRO_0000157818"
FT BINDING 67..75
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 209
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 245..247
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
SQ SEQUENCE 336 AA; 36459 MW; 8B4AACF079CE66C7 CRC64;
MAMMAASHDD DTVDGLATAV RGGDRAALPR AITLVESTRP DHREQAQQLL LRLLPDSGNA
HRVGITGVPG VGKSTAIEAL GMHLIERGHR VAVLAVDPSS TRTGGSILGD KTRMARLAVH
PNAYIRPSPT SGTLGGVTRA TRETVVLLEA AGFDVILIET VGVGQSEVAV ANMVDTFVLL
TLARTGDQLQ GIKKGVLELA DIVVVNKADG EHHKEARLAA RELSAAIRLI YPREALWRPP
VLTMSAVEGR GLAELWDTVE RHRQVLTGAG EFDARRRDQQ VDWTWQLVRD AVLDRVWSNP
TVRKVRSELE RRVRAGELTP ALAAQQILEI ANLTDR
//
