ID Y2098_DICDI Reviewed; 1084 AA.
AC Q55A66;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=TNF receptor-associated factor family protein DDB_G0272098;
GN ORFNames=DDB_G0272098;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Probable adapter protein and signal transducer that links
CC members of the tumor necrosis factor receptor family to different
CC signaling pathways by association with the receptor cytoplasmic domain
CC and kinases. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000007; EAL71410.1; -; Genomic_DNA.
DR RefSeq; XP_645327.1; XM_640235.1.
DR AlphaFoldDB; Q55A66; -.
DR SMR; Q55A66; -.
DR STRING; 44689.Q55A66; -.
DR PaxDb; 44689-DDB0216959; -.
DR EnsemblProtists; EAL71410; EAL71410; DDB_G0272098.
DR GeneID; 8618289; -.
DR KEGG; ddi:DDB_G0272098; -.
DR dictyBase; DDB_G0272098; trafP.
DR HOGENOM; CLU_285667_0_0_1; -.
DR InParanoid; Q55A66; -.
DR PRO; PR:Q55A66; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00121; MATH; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131:SF65; RING FINGER PROTEIN DG17-RELATED; 1.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR Pfam; PF02176; zf-TRAF; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS50145; ZF_TRAF; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; LIM domain; Metal-binding; Reference proteome;
KW Repeat; Zinc; Zinc-finger.
FT CHAIN 1..1084
FT /note="TNF receptor-associated factor family protein
FT DDB_G0272098"
FT /id="PRO_0000393762"
FT DOMAIN 19..103
FT /note="LIM zinc-binding"
FT DOMAIN 909..1042
FT /note="MATH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT ZN_FING 122..190
FT /note="TRAF-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT ZN_FING 191..248
FT /note="TRAF-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT REGION 348..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..523
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..897
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1056..1084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 265..321
FT /evidence="ECO:0000255"
FT COILED 489..553
FT /evidence="ECO:0000255"
FT COILED 735..852
FT /evidence="ECO:0000255"
FT COMPBIAS 490..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..642
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..755
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 786..812
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 813..851
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 852..872
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1060..1084
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1084 AA; 124146 MW; 293EBC6A79BE7B38 CRC64;
MDIPIIKLLV EKDSISKKYY CPDCGELLIN NFNPEKFKAL QCKNGHTKCL QCWEQHLKLR
KNCLQCKVPV SSIKDLSLNL YIAQKISANK VYCKNRYYET KNFTIDEENG CKEIIRVDEY
EKHIKECPLT YTDCKNYDDF IRANPQIDEK LLKRCGKINK SLLDEHDEQC LYQTITCEHC
NELINRIDHE IHLSEWCSDI PIKCEDCKHV FKKKYIQEHK ESNCPESVID CVYVAGGCQK
KLKRYNMSKH LVTANHHSQY MSKIIEEQNQ DIKELHNFIE NHLSKKFIDL DTIVNIQKYL
IKNKNQKISQ LTEIIKRVDN SFIGLHEFDE LEDYISNTID IISNFDNYKN SNSNNNNNNK
NTNENENTNE NTNENENIDI VGNSDNENNI NENKAENNIN SFIKEQIELI KIKSQQFDIN
SVIEEIRKNY NVEPYQVNGD NAMITSPNKT DVDNLVFDDD EDDFDLEEPQ IVGEFIFNKS
QETIAIPTLI RQQQQQQQQQ QQQQQQQQQQ PPPTPLPPQN TTITNDIQME NINENINNNI
NENNNNNNKN NDDDNITAAT ATNNSNTTST HTILNGTNNE ASMTDINETT STTTTAETTE
ATASESTEES NNTAETTTTT TTTTTTITTA AETVNSTETI TLRTSEKVEE KGKDGLETTE
SFSILNSTEN STISSLKVLS NSMIEPEITT DKENETNIKE SIETKIIESI VESSSPTKSL
LKQGKEQEQK NQNGNGNENE NENENENENE NENENENENA NANVNEKENE KENSNINTSN
DTEPTNDILE DIKKNKENED SNESEDNKNN NIKSVEDTNN NNNNNNNNNN NNNNNNNNNN
NNNNNNNNNE NVYDIKKDRN RENVEDSNDN NSKNENGKIN DNGDVKMGSE DKVNDDDDKM
AMVDRSNTIF RNQILFKDFT KLNARHGVGV SIKHNHTIGK YKFYSELFIN GETENEKDYL
SFYLNKCKKE NESIIISFGI ELLNVDPKKS IRVYWDNELL NNSSQVMYNY GYGETTVIKK
SILEDPNNGF LVDNCFIVNL EVYKIIDVPH PPPAHLLQKS SPPAATTTTT TSSSSSKTTP
KTKR
//
