ID Y3403_MYCTU Reviewed; 533 AA.
AC P9WKZ5; L0TFI3; P65071; Q50722;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Uncharacterized protein Rv3403c;
GN OrderedLocusNames=Rv3403c; ORFNames=MTCY78.25;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AL123456; CCP46225.1; -; Genomic_DNA.
DR PIR; H70735; H70735.
DR RefSeq; NP_217920.1; NC_000962.3.
DR RefSeq; WP_003417969.1; NZ_NVQJ01000027.1.
DR PDB; 7ZQJ; X-ray; 2.25 A; F=8-16.
DR PDBsum; 7ZQJ; -.
DR AlphaFoldDB; P9WKZ5; -.
DR SMR; P9WKZ5; -.
DR STRING; 83332.Rv3403c; -.
DR PaxDb; 83332-Rv3403c; -.
DR DNASU; 887907; -.
DR GeneID; 45427399; -.
DR GeneID; 887907; -.
DR KEGG; mtu:Rv3403c; -.
DR TubercuList; Rv3403c; -.
DR eggNOG; COG4529; Bacteria.
DR InParanoid; P9WKZ5; -.
DR OrthoDB; 101972at2; -.
DR PhylomeDB; P9WKZ5; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR038732; HpyO/CreE_NAD-binding.
DR PANTHER; PTHR40254; BLR0577 PROTEIN; 1.
DR PANTHER; PTHR40254:SF1; BLR0577 PROTEIN; 1.
DR Pfam; PF13454; NAD_binding_9; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..533
FT /note="Uncharacterized protein Rv3403c"
FT /id="PRO_0000104123"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 472..492
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 533 AA; 57880 MW; FD575D42C8082B84 CRC64;
MLAFPYLMTM ITPPTFDVAF IGSGAACSMT LLEMADALLS SPSASPKLRI AVVERDEQFW
CGIPYGQRSS IGSLAIQKLD DFADEPEKAA YRIWLEQNKQ RWLAFFQAEG GAAAARWICD
NRDALDGNQW GELYLPRFLF GVFLSEQMIA AIAALGERDL AEIVTIRAEA MSAHSADGHY
RIGLRPSGNG PTAIAAGKVV VAIGSPPTKA ILASDSEPAF TYINDFYSPG GESNVARLRD
SLDRVESWEK RNVLVVGSNA TSLEALYLMR HDARIRARVR SITVISRSGV LPYMICNQPP
EFDFPRLRTL LCTEAIAAAD LMSAIRDDLA TAEERSLNLA DLYDAVAALF GQALHKMDLV
QQEEFFCVHG MNFTKLVRRA GRDCRQASEE LAADGTLSLL AGEVLRVDAC ASGQPFATMT
YRAAGAEHTH PVPFAAVVNC GGFEELDTCS SPFLVSAMQN GLCRPNRTNR GLLVNDDFEA
SPGFCVIGPL VGGNFTPKIR FWHVESAPRV RSLAKSLAAS LLASLQPVAL APC
//
