ID Z4YMV4_MOUSE Unreviewed; 467 AA.
AC Z4YMV4;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Epithelial splicing regulatory protein 1 {ECO:0000313|Ensembl:ENSMUSP00000121117.2};
DE Flags: Fragment;
GN Name=Esrp1 {ECO:0000313|Ensembl:ENSMUSP00000121117.2,
GN ECO:0000313|MGI:MGI:1917326};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000121117.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000121117.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000121117.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000121117.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000121117.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; Z4YMV4; -.
DR SMR; Z4YMV4; -.
DR PeptideAtlas; Z4YMV4; -.
DR ProteomicsDB; 312426; -.
DR Antibodypedia; 6696; 168 antibodies from 29 providers.
DR Ensembl; ENSMUST00000147342.8; ENSMUSP00000121117.2; ENSMUSG00000040728.16.
DR AGR; MGI:1917326; -.
DR MGI; MGI:1917326; Esrp1.
DR VEuPathDB; HostDB:ENSMUSG00000040728; -.
DR GeneTree; ENSGT00940000159511; -.
DR HOGENOM; CLU_008009_2_0_1; -.
DR ChiTaRS; Esrp1; mouse.
DR Proteomes; UP000000589; Chromosome 4.
DR Bgee; ENSMUSG00000040728; Expressed in tail skin and 157 other cell types or tissues.
DR ExpressionAtlas; Z4YMV4; baseline and differential.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd12739; RRM2_ESRP1; 1.
DR CDD; cd12742; RRM3_ESRP1_ESRP2; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR13976:SF37; EPITHELIAL SPLICING REGULATORY PROTEIN 1; 1.
DR PANTHER; PTHR13976; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED; 1.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 2.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:Z4YMV4,
KW ECO:0007829|PeptideAtlas:Z4YMV4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 60..137
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 161..241
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSMUSP00000121117.2"
SQ SEQUENCE 467 AA; 52253 MW; 489EBE8681A57176 CRC64;
NFEKSDSVSR YGASQVEDMG NIILAMISEP YNHRFSDPER VNYKFESGTC SKMELIDDST
VVRARGLPWQ SSDQDIARFF KGLNIAKGGA ALCLNAQGRR NGEALVRFVS EEHRDLALQR
HKHHMGTRYI EVYKATGEDF LKIAGGTSNE VAQFLSKENQ VIVRMRGLPF TATAEEVVAF
FGQHCPITGG KEGILFVTYP DGRPTGDAFV LFACEEYAQN ALRKHKELLG KRYIELFRST
AAEVQQVLNR FSSAPLIPLP TPPIIPVLPQ QFVPPTNVRD CIRLRGLPYA ATIEDILDFL
GEFSTDIRTH GVHMVLNHQG RPSGDAFIQM KSTDRAFMAA QKYHKKTMKD RYVEVFQCSA
EEMNFVLMGG TLNRNGLSPP PCLSPPSYTF PAPTAVIPTE AAIYQPSLLL NPRALQPSTA
YYPAGTQLFM NYTAYYPSMQ PRMDLYTQMT RPGLYPKNGF VFKGPSS
//
