ID ZIP5_ORYSJ Reviewed; 353 AA.
AC Q6L8G0; A0A0P0WNH4; Q7Y247;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE RecName: Full=Zinc transporter 5;
DE AltName: Full=ZRT/IRT-like protein 5;
DE Short=OsZIP5;
DE Flags: Precursor;
GN Name=ZIP5; Synonyms=ZIP2; OrderedLocusNames=Os05g0472700, LOC_Os05g39560;
GN ORFNames=P0015C02.14, P0486C01.1;
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Jiu Caiqing; TISSUE=Root;
RA Huang J., Zhang H.;
RT "Molecular characterization of a ZIP family in rice(Oryza sativa L.).";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16263903; DOI=10.1093/jxb/eri317;
RA Ishimaru Y., Suzuki M., Kobayashi T., Takahashi M., Nakanishi H., Mori S.,
RA Nishizawa N.K.;
RT "OsZIP4, a novel zinc-regulated zinc transporter in rice.";
RL J. Exp. Bot. 56:3207-3214(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16261349; DOI=10.1007/s00438-005-0039-y;
RA Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J.,
RA Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F.,
RA Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y.;
RT "A fine physical map of the rice chromosome 5.";
RL Mol. Genet. Genomics 274:337-345(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [6]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [8]
RP FUNCTION, SUBCELLULAR LOCATION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=20419467; DOI=10.1007/s11103-010-9637-0;
RA Lee S., Jeong H.J., Kim S.A., Lee J., Guerinot M.L., An G.;
RT "OsZIP5 is a plasma membrane zinc transporter in rice.";
RL Plant Mol. Biol. 73:507-517(2010).
CC -!- FUNCTION: Zinc transporter that mediates zinc uptake from the
CC rhizosphere and may be responsible for the translocation of zinc within
CC the plant. {ECO:0000269|PubMed:20419467}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20419467};
CC Multi-pass membrane protein {ECO:0000269|PubMed:20419467}.
CC -!- INDUCTION: By zinc deficiency in roots and shoots.
CC {ECO:0000269|PubMed:20419467}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype, but increased tolerance to
CC an excess of zinc. {ECO:0000269|PubMed:20419467}.
CC -!- MISCELLANEOUS: Plants overexpressing ZIP5 show decreased zinc
CC concentration in shoots, increased concentration in roots, and are
CC sensitive to an excess of zinc.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000305}.
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DR EMBL; AY281300; AAP33800.1; -; mRNA.
DR EMBL; AB126087; BAD18965.1; -; mRNA.
DR EMBL; AC135423; AAT94022.1; -; Genomic_DNA.
DR EMBL; AC135924; AAU44233.1; -; Genomic_DNA.
DR EMBL; AP008211; BAF17732.1; -; Genomic_DNA.
DR EMBL; AP014961; BAS94503.1; -; Genomic_DNA.
DR EMBL; AK070864; BAG92180.1; -; mRNA.
DR RefSeq; XP_015637510.1; XM_015782024.1.
DR AlphaFoldDB; Q6L8G0; -.
DR SMR; Q6L8G0; -.
DR STRING; 39947.Q6L8G0; -.
DR PaxDb; 39947-Q6L8G0; -.
DR EnsemblPlants; Os05t0472700-01; Os05t0472700-01; Os05g0472700.
DR GeneID; 4339082; -.
DR Gramene; Os05t0472700-01; Os05t0472700-01; Os05g0472700.
DR KEGG; osa:4339082; -.
DR eggNOG; KOG1558; Eukaryota.
DR HOGENOM; CLU_027089_3_0_1; -.
DR InParanoid; Q6L8G0; -.
DR OMA; PLWCFRQ; -.
DR OrthoDB; 1112460at2759; -.
DR Proteomes; UP000000763; Chromosome 5.
DR Proteomes; UP000059680; Chromosome 5.
DR Genevisible; Q6L8G0; OS.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006829; P:zinc ion transport; IMP:UniProtKB.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR004698; Zn/Fe_permease_fun/pln.
DR NCBIfam; TIGR00820; zip; 1.
DR PANTHER; PTHR11040:SF67; ZINC TRANSPORTER 5; 1.
DR PANTHER; PTHR11040; ZINC/IRON TRANSPORTER; 1.
DR Pfam; PF02535; Zip; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Ion transport; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Transport; Zinc; Zinc transport.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..353
FT /note="Zinc transporter 5"
FT /id="PRO_0000398329"
FT TOPO_DOM 28..48
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..86
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..121
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 143..198
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..230
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..260
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 261..281
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 282..292
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 314..332
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 353 AA; 36754 MW; 47E9BB397D130395 CRC64;
MATAAMTKVF VLLFLVAACY LPAHAAAAEC DCATDTAGRD KAQALRLKVI AIFCILAGST
VGAALPSLGG RFPAIQPETD VFLSVKAFAG GVILATGLVH ILPAAFEALS SPCLVGGPWK
RFPFAGMVAM VSAIGTLIVD TVATGYFHRT DAKRKAAAVA DEPADDLEAS DEHSHGHAHG
MSVMSVAPAG EEDLVRHRVI SQVLELGVVV HSLIIGMSLG ASDFPSTVRP LVPALTFHQF
FEGIGLGGCI VQAKFRVRSV VTMALFFSLT TPAGIVVGIG ISSVYDANSP TALVVQGLLE
AAAAGILVYM ALVDILAEDF MKTKVQRRGR LQLAMNVALL LGAGLMSMIA IWA
//
