ID ZSWM1_HUMAN Reviewed; 485 AA.
AC Q9BR11; Q5JZH2; Q9BR12; Q9BV30;
DT 25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 2.
DT 24-JAN-2024, entry version 143.
DE RecName: Full=Zinc finger SWIM domain-containing protein 1;
GN Name=ZSWIM1; Synonyms=C20orf162;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL008726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC001672; AAH01672.3; -; mRNA.
DR EMBL; BC080525; AAH80525.2; -; mRNA.
DR CCDS; CCDS13382.2; -.
DR RefSeq; NP_542170.3; NM_080603.4.
DR RefSeq; XP_005260667.1; XM_005260610.4.
DR RefSeq; XP_005260668.1; XM_005260611.4.
DR RefSeq; XP_011527402.1; XM_011529100.2.
DR AlphaFoldDB; Q9BR11; -.
DR BioGRID; 124678; 3.
DR IntAct; Q9BR11; 4.
DR MINT; Q9BR11; -.
DR STRING; 9606.ENSP00000361601; -.
DR GlyGen; Q9BR11; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9BR11; -.
DR PhosphoSitePlus; Q9BR11; -.
DR BioMuta; ZSWIM1; -.
DR DMDM; 73920980; -.
DR EPD; Q9BR11; -.
DR MassIVE; Q9BR11; -.
DR MaxQB; Q9BR11; -.
DR PaxDb; 9606-ENSP00000361601; -.
DR PeptideAtlas; Q9BR11; -.
DR ProteomicsDB; 78737; -.
DR Antibodypedia; 27817; 89 antibodies from 16 providers.
DR DNASU; 90204; -.
DR Ensembl; ENST00000372523.1; ENSP00000361601.1; ENSG00000168612.5.
DR GeneID; 90204; -.
DR KEGG; hsa:90204; -.
DR MANE-Select; ENST00000372523.1; ENSP00000361601.1; NM_080603.5; NP_542170.3.
DR UCSC; uc010ghi.4; human.
DR AGR; HGNC:16155; -.
DR CTD; 90204; -.
DR GeneCards; ZSWIM1; -.
DR HGNC; HGNC:16155; ZSWIM1.
DR HPA; ENSG00000168612; Low tissue specificity.
DR neXtProt; NX_Q9BR11; -.
DR OpenTargets; ENSG00000168612; -.
DR PharmGKB; PA25704; -.
DR VEuPathDB; HostDB:ENSG00000168612; -.
DR eggNOG; ENOG502RNJT; Eukaryota.
DR GeneTree; ENSGT00390000017273; -.
DR HOGENOM; CLU_563302_0_0_1; -.
DR InParanoid; Q9BR11; -.
DR OMA; FGTTPCV; -.
DR OrthoDB; 5296025at2759; -.
DR PhylomeDB; Q9BR11; -.
DR TreeFam; TF335703; -.
DR PathwayCommons; Q9BR11; -.
DR SignaLink; Q9BR11; -.
DR BioGRID-ORCS; 90204; 11 hits in 1159 CRISPR screens.
DR ChiTaRS; ZSWIM1; human.
DR GenomeRNAi; 90204; -.
DR Pharos; Q9BR11; Tdark.
DR PRO; PR:Q9BR11; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9BR11; Protein.
DR Bgee; ENSG00000168612; Expressed in pancreatic ductal cell and 108 other cell types or tissues.
DR Genevisible; Q9BR11; HS.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR InterPro; IPR007527; Znf_SWIM.
DR InterPro; IPR048326; ZSWIM1-3_helical.
DR InterPro; IPR048324; ZSWIM1-3_RNaseH-like.
DR InterPro; IPR045563; ZSWIM1/3_C.
DR PANTHER; PTHR31569; SWIM-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR31569:SF0; ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF04434; SWIM; 1.
DR Pfam; PF19286; ZSWIM1-3_C; 1.
DR Pfam; PF21600; ZSWIM1-3_helical; 1.
DR Pfam; PF21056; ZSWIM1-3_RNaseH-like; 1.
DR PROSITE; PS50966; ZF_SWIM; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..485
FT /note="Zinc finger SWIM domain-containing protein 1"
FT /id="PRO_0000223095"
FT ZN_FING 363..405
FT /note="SWIM-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00325"
FT VARIANT 101
FT /note="R -> Q (in dbSNP:rs3746500)"
FT /id="VAR_020445"
SQ SEQUENCE 485 AA; 55071 MW; F7447E98EFC6FD6E CRC64;
MLERLKAPWS AALQRKYFDL GIWTAPISPM ALTMLNGLLI KDSSPPMLLH QVNKTAQLDT
FNYQSCFMQS VFDHFPEILF IHRTYNPRGK VLYTFLVDGP RVQLEGHLAR AVYFAIPAKE
DTEGLAQMFQ VFKKFNPAWE RVCTILVDPH FLPLPILAME FPTAEVLLSA FHICKFLQAK
FYQLSLERPV ERLLLTSLQS TMCSATAGNL RKLYTLLSNC IPPAKLPELH SHWLLNDRIW
LAHRWRSRAE SSHYFQSLEV TTHILSQFFG TTPSEKQGMA SLFRYMQQNS ADKANFNQGL
CAQNNHAPSD TIPESPKLEQ LVESHIQHSL NAICTGPAAQ LCLGELAVVQ KSTHLIGSGS
EKMNIQILED THKVQPQPPA SCSCYFNQAF HLPCRHILAM LSARRQVLQP DMLPAQWTAG
CATSLDSILG SKWSETLDKH LAVTHLTEEV GQLLQHCTKE EFERRYSTLR ELADSWIGPY
EQVQL
//
