PCIDB

phytochemical cluster No. 16 (4 metabolites)

Plant Species

Cumulative plant class count

class name count
rosids 6

Cumulative family count

class name count
Fabaceae 6

KEGG BRITE br08003 External link 512

Categories (1)

br08003 Category # of metabolite
3-Arylcoumarins 1

metabolites link (1)

br08003 Category KEGG ID KNApSAcK ID
3-Arylcoumarins C10491 C00002543

KCF-S cluster (1)

KCF-S ID # of metabolite
No. 2734 4

Metabolite list (4)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		figure
C00002543 External link 512 Scandenin
CHEMBL1603825
9 / 6 / 8 No. 2734
C00009792 External link 512 Chandanin
/ Lonchocarpic acid
CHEMBL1527366
12 / 12 / 17 No. 2734
C00009793 External link 512 Lonchocarpenin
No. 2734
C00019585 External link 512 di-O-Methyl scandenin
No. 2734

Human Protein / Gene in interactions

14 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00009792 C00009793 0 / 1
P11473 Vitamin D3 receptor NR1I1 C00009792 C00009793 2 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00009792 C00009793 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00009792 C00009793 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00009792 C00009793 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00009792 C00009793 3 / 3
Q9UBT6 DNA polymerase kappa Enzyme C00009792 C00009793 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00009793 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00009793 4 / 3
P16050 Arachidonate 15-lipoxygenase Enzyme C00009793 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00009792 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00009792 1 / 1
O00255 Menin Unclassified protein C00009793 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00009793 1 / 2

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (13)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (18)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)