Plant Species


Cumulative plant class count

class name count
eudicotyledons 1
asterids 1
Spermatophyta 1

Cumulative family count

class name count
Papaveraceae 1
Apiaceae 1
Streptomycetaceae 1
Taxaceae 1

KEGG BRITE br08003 External link 512


Categories (1)

br08003 Category # of metabolite
Monocyclic gamma-pyrones 2

metabolites link (2)

br08003 Category KEGG ID KNApSAcK ID
Monocyclic gamma-pyrones C08476 C00001304
Monocyclic gamma-pyrones C11918 C00037471

KCF-S cluster (2)

KCF-S ID # of metabolite
No. 4868 2
No. 6561 1

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
figure
C00041026 External link 512 Chelidonic acid
C046884
No. 4868
C00037471 External link 512 Kojic acid
CHEMBL287556
C011890
8 / 8 / 6 311 / 8 No. 4868
C00001304 External link 512 Maltol
CHEMBL31422
C008316
12 / 15 / 14 No. 6561

Human Protein / Gene in interactions

13 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00037471 C00041026 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00037471 C00041026 0 / 0
P22894 Neutrophil collagenase M10A C00037471 C00041026 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00037471 C00041026 2 / 2
P08254 Stromelysin-1 M10A C00037471 C00041026 1 / 0
P03956 Interstitial collagenase M10A C00037471 C00041026 0 / 1
P08253 72 kDa type IV collagenase M10A C00037471 C00041026 1 / 3
P14679 Tyrosinase Oxidoreductase C00041026 4 / 2
O75164 Lysine-specific demethylase 4A Enzyme C00037471 0 / 0
Q04760 Lactoylglutathione lyase Enzyme C00037471 0 / 0
P02545 Prelamin-A/C Unclassified protein C00037471 11 / 10
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00037471 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00037471 0 / 0

311 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
79963 ABCA11P, ABCA11, EST1133530 ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene C00041026
154664 ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 C00041026
150000 ABCC13, C21orf73, PRED6 ATP-binding cassette, sub-family C (CFTR/MRP), member 13, pseudogene C00041026
55331 ACER3, APHC, PHCA alkaline ceramidase 3 (EC:3.5.1.23) C00041026
130013 ACMSD aminocarboxymuconate semialdehyde decarboxylase (EC:4.1.1.45) C00041026
94 ACVRL1, ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I activin A receptor type II-like 1 (EC:2.7.11.30) C00041026
8748 ADAM20 ADAM metallopeptidase domain 20 C00041026
56997 ADCK3, ARCA2, CABC1, COQ10D4, COQ8, SCAR9 aarF domain containing kinase 3 C00041026
155 ADRB3, BETA3AR adrenoceptor beta 3 C00041026
116988 AGAP3, AGAP-3, CENTG3, CRAG, MRIP-1, cnt-g3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 C00041026
84871 AGBL4, CCP6 ATP/GTP binding protein-like 4 C00041026
79026 AHNAK, AHNAKRS AHNAK nucleoprotein C00041026
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00041026
248 ALPI, IAP alkaline phosphatase, intestinal (EC:3.1.3.1) C00041026
401138 AMTN, UNQ689 amelotin C00041026
301 ANXA1, ANX1, LPC1 annexin A1 C00041026
1174 AP1S1, AP19, CLAPS1, MEDNIK, SIGMA1A, WUGSC:H_DJ0747G18.2 adaptor-related protein complex 1, sigma 1 subunit C00041026
339 APOBEC1, APOBEC-1, BEDP, CDAR1, HEPR apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 C00041026
351 APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2 amyloid beta (A4) precursor protein C00041026
54840 APTX, AOA, AOA1, AXA1, EAOH, EOAHA, FHA-HIT aprataxin C00041026
358 AQP1, AQP-CHIP, CHIP28, CO aquaporin 1 C00041026
23647 ARFIP2, POR1 ADP-ribosylation factor interacting protein 2 C00041026
27237 ARHGEF16, GEF16, NBR Rho guanine nucleotide exchange factor (GEF) 16 C00041026
10550 ARL6IP5, DERP11, GTRAP3-18, JWA, PRAF3, addicsin, hp22, jmx ADP-ribosylation-like factor 6 interacting protein 5 C00041026
55130 ARMC4, CILD23 armadillo repeat containing 4 C00041026
54529 ASNSD1, NBLA00058, NS3TP1 asparagine synthetase domain containing 1 C00041026
1388 ATF6B, CREB-RP, CREBL1, G13 activating transcription factor 6 beta C00041026
338707 B4GALNT4 beta-1,4-N-acetyl-galactosaminyl transferase 4 (EC:2.4.1.244) C00041026
9529 BAG5, BAG-5 BCL2-associated athanogene 5 C00041026
597 BCL2A1, ACC-1, ACC-2, BCL2L5, BFL1, GRS, HBPA1 BCL2-related protein A1 C00041026
329 BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 baculoviral IAP repeat containing 2 C00041026
653 BMP5 bone morphogenetic protein 5 C00041026
84446 BRSK1, hSAD1 BR serine/threonine kinase 1 (EC:2.7.11.1 2.7.11.26) C00041026
684 BST2, CD317, TETHERIN bone marrow stromal cell antigen 2 C00041026
57102 C12orf4 chromosome 12 open reading frame 4 C00041026
84529 C15orf41, HH114 chromosome 15 open reading frame 41 C00041026
128061 C1orf131 chromosome 1 open reading frame 131 C00041026
84808 C1orf170, RP11-54O7.8 chromosome 1 open reading frame 170 C00041026
79630 C1orf54 chromosome 1 open reading frame 54 C00041026
127795 C1orf87 chromosome 1 open reading frame 87 C00041026
132720 C4orf32 chromosome 4 open reading frame 32 C00041026
23632 CA14, CAXiV carbonic anhydrase XIV (EC:4.2.1.1) C00041026
81617 CAB39L, MO25-BETA, MO2L, bA103J18.3 calcium binding protein 39-like C00041026
55749 CCAR1, RP11-437A18.1 cell division cycle and apoptosis regulator 1 C00041026
9720 CCDC144A coiled-coil domain containing 144A C00041026
152137 CCDC50, C3orf6, DFNA44, YMER coiled-coil domain containing 50 C00041026
9236 CCPG1, CPR8 cell cycle progression 1 C00041026
1233 CCR4, CC-CKR-4, CD194, CKR4, CMKBR4, ChemR13, HGCN:14099, K5-5 chemokine (C-C motif) receptor 4 C00041026
933 CD22, SIGLEC-2, SIGLEC2 CD22 molecule C00041026
29126 CD274, B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1 CD274 molecule C00041026
917 CD3G, CD3-GAMMA, T3G CD3g molecule, gamma (CD3-TCR complex) C00041026
8558 CDK10, PISSLRE cyclin-dependent kinase 10 (EC:2.7.11.22) C00041026
634 CEACAM1, BGP, BGP1, BGPI carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) C00041026
1052 CEBPD, C/EBP-delta, CELF, CRP3, NF-IL6-beta CCAAT/enhancer binding protein (C/EBP), delta C00041026
55166 CENPQ, C6orf139, CENP-Q centromere protein Q C00041026
55125 CEP192, PPP1R62 centrosomal protein 192kDa C00041026
55722 CEP72 centrosomal protein 72kDa C00041026
1365 CLDN3, C7orf1, CPE-R2, CPETR2, HRVP1, RVP1 claudin 3 C00041026
125875 CLDND2 claudin domain containing 2 C00041026
170482 CLEC4C, BDCA2, CD303, CLECSF11, CLECSF7, DLEC, HECL, PRO34150 C-type lectin domain family 4, member C C00041026
79827 CLMP, ACAM, ASAM, CSBM, CSBS CXADR-like membrane protein C00041026
10175 CNIH1, CNIH, CNIH-1, CNIL, TGAM77 cornichon family AMPA receptor auxiliary protein 1 C00041026
22866 CNKSR2, CNK2, KSR2, MAGUIN connector enhancer of kinase suppressor of Ras 2 C00041026
1308 COL17A1, BA16H23.2, BP180, BPA-2, BPAG2, LAD-1 collagen, type XVII, alpha 1 C00041026
255631 COL24A1 collagen, type XXIV, alpha 1 C00041026
8292 COLQ, EAD collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase C00041026
9318 COPS2, ALIEN, CSN2, SGN2, TRIP15 COP9 signalosome subunit 2 C00041026
93058 COQ10A coenzyme Q10 homolog A (S. cerevisiae) C00041026
1360 CPB1, CPB, PASP, PCPB carboxypeptidase B1 (tissue) (EC:3.4.17.2) C00041026
1363 CPE carboxypeptidase E (EC:3.4.17.10) C00041026
57699 CPNE5, COPN5, CPN5 copine V C00041026
1434 CSE1L, CAS, CSE1, XPO2 CSE1 chromosome segregation 1-like (yeast) C00041026
8727 CTNNAL1, CLLP, alpha-CATU catenin (cadherin-associated protein), alpha-like 1 C00041026
1522 CTSZ, CTSX cathepsin Z (EC:3.4.18.1) C00041026
56603 CYP26B1, CYP26A2, P450RAI-2, P450RAI2, RHFCA cytochrome P450, family 26, subfamily B, polypeptide 1 C00041026
9265 CYTH3, ARNO3, GRP1, PSCD3 cytohesin 3 C00041026
9595 CYTIP, B3-1, CASP, CYBR, CYTHIP, HE, PSCDBP cytohesin 1 interacting protein C00041026
747 DAGLA, C11orf11, DAGL(ALPHA), DAGLALPHA, NSDDR diacylglycerol lipase, alpha (EC:3.1.1.-) C00041026
9802 DAZAP2, PRTB DAZ associated protein 2 C00041026
25879 DCAF13, GM83, WDSOF1 DDB1 and CUL4 associated factor 13 C00041026
7913 DEK, D6S231E DEK oncogene C00041026
22839 DLGAP4, DAP4, DLP4, RP5-977B1.6, SAPAP4 discs, large (Drosophila) homolog-associated protein 4 C00041026
1745 DLX1 distal-less homeobox 1 C00041026
1657 DMXL1 Dmx-like 1 C00041026
30836 DNTTIP2, ERBP, FCF2, HSU15552, LPTS-RP2, TdIF2 deoxynucleotidyltransferase, terminal, interacting protein 2 C00041026
9732 DOCK4 dedicator of cytokinesis 4 C00041026
55715 DOK4 docking protein 4 C00041026
1834 DSPP, DFNA39, DGI1, DMP3, DPP, DSP, DTDP2 dentin sialophosphoprotein C00041026
11034 DSTN, ACTDP, ADF, bA462D18.2 destrin (actin depolymerizing factor) C00041026
6990 DYNLT3, RP3, TCTE1L, TCTEX1L dynein, light chain, Tctex-type 3 C00041026
1871 E2F3, E2F-3 E2F transcription factor 3 C00041026
79733 E2F8, E2F-8 E2F transcription factor 8 C00041026
1944 EFNA3, EFL2, EPLG3, Ehk1-L, LERK3 ephrin-A3 C00041026
1977 EIF4E, AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F eukaryotic translation initiation factor 4E C00041026
56648 EIF5A2, EIF-5A2, eIF5AII eukaryotic translation initiation factor 5A2 C00041026
1991 ELANE, ELA2, GE, HLE, HNE, NE, PMN-E, SCN1 elastase, neutrophil expressed (EC:3.4.21.37) C00041026
2033 EP300, KAT3B, RSTS2, p300 E1A binding protein p300 (EC:2.3.1.48) C00041026
284656 EPHA10 EPH receptor A10 (EC:2.7.10.1) C00041026
2043 EPHA4, HEK8, SEK, TYRO1 EPH receptor A4 (EC:2.7.10.1) C00041026
90952 ESAM, W117m endothelial cell adhesion molecule C00041026
54845 ESRP1, RBM35A, RMB35A epithelial splicing regulatory protein 1 C00041026
161829 EXD1, EXDL1 exonuclease 3'-5' domain containing 1 C00041026
55770 EXOC2, SEC5, SEC5L1, Sec5p exocyst complex component 2 C00041026
2159 F10, FX, FXA coagulation factor X (EC:3.4.21.6) C00041026
116224 FAM122A, C9orf42 family with sequence similarity 122A C00041026
137392 FAM92A1 family with sequence similarity 92, member A1 C00041026
2201 FBN2, CCA, DA9 fibrillin 2 C00041026
157574 FBXO16, FBX16 F-box protein 16 C00041026
2257 FGF12, FGF12B, FHF1 fibroblast growth factor 12 C00041026
2250 FGF5, HBGF-5, Smag-82 fibroblast growth factor 5 C00041026
2261 FGFR3, ACH, CD333, CEK2, HSFGFR3EX, JTK4 fibroblast growth factor receptor 3 (EC:2.7.10.1) C00041026
84929 FIBCD1 fibrinogen C domain containing 1 C00041026
60681 FKBP10, FKBP65, OI11, OI6, PPIASE, hFKBP65 FK506 binding protein 10, 65 kDa (EC:5.2.1.8) C00041026
8790 FPGT, GFPP fucose-1-phosphate guanylyltransferase (EC:2.7.7.30) C00041026
9758 FRMPD4, PDZD10, PDZK10 FERM and PDZ domain containing 4 C00041026
8325 FZD8, FZ-8, hFZ8 frizzled family receptor 8 C00041026
100121905 C00041026
2589 GALNT1, GALNAC-T1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) (EC:2.4.1.41) C00041026
54438 GFOD1, ADG-90, C6orf114 glucose-fructose oxidoreductase domain containing 1 C00041026
2733 GLE1, GLE1L, LCCS, LCCS1, hGLE1 GLE1 RNA export mediator C00041026
2766 GMPR, GMPR1 guanosine monophosphate reductase (EC:1.7.1.7) C00041026
2782 GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 C00041026
115330 GPR146, PGR8 G protein-coupled receptor 146 C00041026
2849 GPR26 G protein-coupled receptor 26 C00041026
2854 GPR32, RVDR1 G protein-coupled receptor 32 C00041026
83873 GPR61, BALGR, GPCR3 G protein-coupled receptor 61 C00041026
284110 GSDMA, GSDM, GSDM1 gasdermin A C00041026
2977 GUCY1A2, GC-SA2, GUC1A2 guanylate cyclase 1, soluble, alpha 2 (EC:4.6.1.2) C00041026
9421 HAND1, Hxt, Thing1, bHLHa27, eHand heart and neural crest derivatives expressed 1 C00041026
283254 HARBI1, C11orf77 harbinger transposase derived 1 (EC:3.1.-.-) C00041026
26275 HIBCH, HIBYLCOAH 3-hydroxyisobutyryl-CoA hydrolase (EC:3.1.2.4) C00041026
135114 HINT3, HINT4 histidine triad nucleotide binding protein 3 (EC:3.-.-.-) C00041026
3092 HIP1, HIP-I, ILWEQ huntingtin interacting protein 1 C00041026
3024 HIST1H1A, H1.1, H1A, H1F1, HIST1 histone cluster 1, H1a C00041026
8334 HIST1H2AC, H2A/l, H2AFL, dJ221C16.4 histone cluster 1, H2ac C00041026
8331 HIST1H2AJ, H2A/E, H2AFE, dJ160A22.4 histone cluster 1, H2aj C00041026
3131 HLF hepatic leukemia factor C00041026
3161 HMMR, CD168, IHABP, RHAMM hyaluronan-mediated motility receptor (RHAMM) C00041026
3188 HNRNPH2, FTP3, HNRPH', HNRPH2, hnRNPH' heterogeneous nuclear ribonucleoprotein H2 (H') C00041026
84343 HPS3, SUTAL Hermansky-Pudlak syndrome 3 C00041026
58985 IL22RA1, CRF2-9, IL22R, IL22R1 interleukin 22 receptor, alpha 1 C00041026
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00041026
3572 IL6ST, CD130, CDW130, GP130, IL-6RB interleukin 6 signal transducer (gp130, oncostatin M receptor) C00041026
3619 INCENP inner centromere protein antigens 135/155kDa C00041026
3735 KARS, CMTRIB, DFNB89, KARS1, KARS2, KRS lysyl-tRNA synthetase (EC:6.1.1.6) C00041026
9196 KCNAB3, AKR6A9, KCNA3.1B, KCNA3B, KV-BETA-3 potassium voltage-gated channel, shaker-related subfamily, beta member 3 C00041026
79734 KCTD17 potassium channel tetramerization domain containing 17 C00041026
79070 KDELC1, EP58, KDEL1 KDEL (Lys-Asp-Glu-Leu) containing 1 C00041026
55693 KDM4D, JMJD2D lysine (K)-specific demethylase 4D C00041026
688 KLF5, BTEB2, CKLF, IKLF Kruppel-like factor 5 (intestinal) C00041026
90293 KLHL13, BKLHD2, KIAA1309 kelch-like family member 13 C00041026
3818 KLKB1, KLK3, PPK kallikrein B, plasma (Fletcher factor) 1 (EC:3.4.21.34) C00041026
3855 KRT7, CK7, K2C7, K7, SCL keratin 7 C00041026
3895 KTN1, CG1, KNT, MU-RMS-40.19 kinectin 1 (kinesin receptor) C00041026
51574 LARP7, ALAZS, PIP7S La ribonucleoprotein domain family, member 7 C00041026
10990 LILRB5, CD85C, LIR-8, LIR8 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 C00041026
4040 LRP6, ADCAD2 low density lipoprotein receptor-related protein 6 C00041026
64101 LRRC4, NGL-2 leucine rich repeat containing 4 C00041026
341883 LRRC9 leucine rich repeat containing 9 C00041026
10296 MAEA, EMLP, EMP, GID9, HLC-10, PIG5 macrophage erythroblast attacher C00041026
7975 MAFK, NFE2U, P18 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K C00041026
51438 MAGEC2, CT10, HCA587, MAGEE1 melanoma antigen family C, 2 C00041026
64110 MAGEF1 melanoma antigen family F, 1 C00041026
256714 MAP7D2 MAP7 domain containing 2 C00041026
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00041026
4154 MBNL1, EXP, EXP35, EXP40, EXP42, MBNL muscleblind-like splicing regulator 1 C00041026
4188 MDFI, I-MF, I-mfa MyoD family inhibitor C00041026
10873 ME3, NADP-ME malic enzyme 3, NADP(+)-dependent, mitochondrial (EC:1.1.1.40) C00041026
9282 MED14, CRSP150, CRSP2, CSRP, CXorf4, DRIP150, EXLM1, RGR1, TRAP170 mediator complex subunit 14 C00041026
84206 MEX3B, MEX-3B, RKHD3, RNF195 mex-3 RNA binding family member B C00041026
4239 MFAP4 microfibrillar-associated protein 4 C00041026
90007 MIDN midnolin C00041026
51263 MRPL30, L28MT, L30MT, MRP-L28, MRP-L30, MRPL28, MRPL28M, RPML28 mitochondrial ribosomal protein L30 C00041026
80018 NAA25, C12orf30, MDM20, NAP1 N(alpha)-acetyltransferase 25, NatB auxiliary subunit C00041026
83988 NCALD neurocalcin delta C00041026
4694 NDUFA1, CI-MWFE, MWFE, ZNF183 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa (EC:1.6.99.3) C00041026
4783 NFIL3, E4BP4, IL3BP1, NF-IL3A, NFIL3A nuclear factor, interleukin 3 regulated C00041026
4794 NFKBIE, IKBE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon C00041026
4825 NKX6-1, NKX6.1, NKX6A NK6 homeobox 1 C00041026
57555 NLGN2 neuroligin 2 C00041026
64318 NOC3L, AD24, C10orf117, FAD24 nucleolar complex associated 3 homolog (S. cerevisiae) C00041026
25926 NOL11 nucleolar protein 11 C00041026
170685 NUDT10, APS2, DIPP3a, hDIPP3alpha nudix (nucleoside diphosphate linked moiety X)-type motif 10 (EC:3.6.1.52 3.6.1.60) C00041026
283298 OLFML1, UNQ564 olfactomedin-like 1 C00041026
79339 OR51B4, HOR5'Beta1 olfactory receptor, family 51, subfamily B, member 4 C00041026
23762 OSBP2, HLM, ORP-4, ORP4, OSBPL1, OSBPL4 oxysterol binding protein 2 C00041026
28962 OSTM1, GIPN, GL, OPTB5 osteopetrosis associated transmembrane protein 1 C00041026
5013 OTX1 orthodenticle homeobox 1 C00041026
79447 PAGR1, C16orf53, GAS, PA1 PAXIP1 associated glutamate-rich protein 1 C00041026
5053 PAH, PH, PKU, PKU1 phenylalanine hydroxylase (EC:1.14.16.1) C00041026
64282 PAPD5, TRF4-2 PAP associated domain containing 5 C00041026
8505 PARG, PARG99 poly (ADP-ribose) glycohydrolase (EC:3.2.1.143) C00041026
399909 PCNXL3 pecanex-like 3 (Drosophila) C00041026
54760 PCSK4, PC4, SPC5 proprotein convertase subtilisin/kexin type 4 C00041026
5082 PDCL, PhLP phosducin-like C00041026
5160 PDHA1, PDHA, PDHCE1A, PHE1A pyruvate dehydrogenase (lipoamide) alpha 1 (EC:1.2.4.1) C00041026
64236 PDLIM2, MYSTIQUE, SLIM PDZ and LIM domain 2 (mystique) C00041026
51555 PEX5L, PEX5R, PEX5RP, PXR2, PXR2B, TRIP8b peroxisomal biogenesis factor 5-like C00041026
55276 PGM2 phosphoglucomutase 2 (EC:5.4.2.2 5.4.2.7) C00041026
9091 PIGQ, GPI1, c407A10.1 phosphatidylinositol glycan anchor biosynthesis, class Q (EC:2.4.1.198) C00041026
23760 PITPNB, PI-TP-beta, PtdInsTP, VIB1B phosphatidylinositol transfer protein, beta C00041026
5325 PLAGL1, LOT1, ZAC, ZAC1 pleiomorphic adenoma gene-like 1 C00041026
25833 POU2F3, Epoc-1, OCT-11, OCT11, OTF-11, PLA-1, PLA1, Skn-1a POU class 2 homeobox 3 C00041026
9989 PPP4R1, MEG1, PP4(Rmeg), PP4R1 protein phosphatase 4, regulatory subunit 1 C00041026
5553 PRG2, BMPG, MBP, MBP1 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) C00041026
4007 PRICKLE3, LMO6 prickle homolog 3 (Drosophila) C00041026
5557 PRIM1, p49 primase, DNA, polypeptide 1 (49kDa) (EC:2.7.7.7) C00041026
3275 PRMT2, HRMT1L1 protein arginine methyltransferase 2 (EC:2.1.1.125) C00041026
55660 PRPF40A, FBP-11, FBP11, FLAF1, FNBP3, HIP-10, HIP10, HYPA, NY-REN-6, Prp40 PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) C00041026
5634 PRPS2, PRSII phosphoribosyl pyrophosphate synthetase 2 (EC:2.7.6.1) C00041026
285800 PRR18 proline rich 18 C00041026
23215 PRRC2C, BAT2-iso, BAT2D1, BAT2L2, XTP2 proline-rich coiled-coil 2C C00041026
5396 PRRX1, AGOTC, PHOX1, PMX1, PRX-1, PRX1 paired related homeobox 1 C00041026
5706 PSMC6, CADP44, P44, SUG2, p42 proteasome (prosome, macropain) 26S subunit, ATPase, 6 C00041026
5709 PSMD3, P58, RPN3, S3, TSTA2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 C00041026
326626 C00041026
43664 C00041026
83448 PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like (EC:5.4.99.-) C00041026
81607 PVRL4, EDSS1, LNIR, PRR4, nectin-4 poliovirus receptor-related 4 C00041026
22930 RAB3GAP1, P130, RAB3GAP, RAB3GAP130, WARBM1 RAB3 GTPase activating protein subunit 1 (catalytic) C00041026
51560 RAB6B RAB6B, member RAS oncogene family C00041026
5810 RAD1, HRAD1, REC1 RAD1 homolog (S. pombe) (EC:3.1.11.2) C00041026
51655 RASD1, AGS1, DEXRAS1, MGC:26290 RAS, dexamethasone-induced 1 C00041026
153020 RASGEF1B, GPIG4 RasGEF domain family, member 1B C00041026
283349 RASSF3, RASSF5 Ras association (RalGDS/AF-6) domain family member 3 C00041026
9821 RB1CC1, CC1, FIP200 RB1-inducible coiled-coil 1 C00041026
55544 RBM38, HSRNASEB, RNPC1, SEB4B, SEB4D, dJ800J21.2 RNA binding motif protein 38 C00041026
5965 RECQL, RECQL1, RecQ1 RecQ protein-like (DNA helicase Q1-like) (EC:3.6.4.12) C00041026
9699 RIMS2, OBOE, RAB3IP3, RIM2 regulating synaptic membrane exocytosis 2 C00041026
54665 RSBN1, ROSBIN, RP11-324J2.1 round spermatid basic protein 1 C00041026
6291 SAA4, C-SAA, CSAA serum amyloid A4, constitutive C00041026
6336 SCN10A, Nav1.8, PN3, SNS, hPN3 sodium channel, voltage-gated, type X, alpha subunit C00041026
6342 SCP2, NLTP, NSL-TP, SCP-2, SCP-CHI, SCP-X, SCPX sterol carrier protein 2 (EC:2.3.1.176) C00041026
6385 SDC4, SYND4 syndecan 4 C00041026
10427 SEC24B, SEC24 SEC24 family member B C00041026
7095 SEC62, Dtrp1, HTP1, TLOC1, TP-1 SEC62 homolog (S. cerevisiae) C00041026
6398 SECTM1, K12 secreted and transmembrane 1 C00041026
989 SEPT7, CDC10, CDC3, NBLA02942, SEPT7A septin 7 C00041026
5104 SERPINA5, PAI-3, PAI3, PCI, PCI-B, PLANH3, PROCI serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 C00041026
79801 SHCBP1, PAL SHC SH2-domain binding protein 1 C00041026
23309 SIN3B SIN3 transcription regulator family member B C00041026
23517 SKIV2L2, Dob1, KIAA0052, Mtr4, fSAP118 superkiller viralicidic activity 2-like 2 (S. cerevisiae) (EC:3.6.4.13) C00041026
10246 SLC17A2, NPT3 solute carrier family 17, member 2 C00041026
83884 SLC25A2, ORC2, ORNT2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 C00041026
83650 SLC35G5, AMAC, AMAC1L2 solute carrier family 35, member G5 C00041026
55089 SLC38A4, ATA3, NAT3, PAAT solute carrier family 38, member 4 C00041026
79677 SMC6, SMC-6, SMC6L1, hSMC6 structural maintenance of chromosomes 6 C00041026
57150 SMIM8, C6orf162, dJ102H19.2 small integral membrane protein 8 C00041026
29887 SNX10, OPTB8 sorting nexin 10 C00041026
8435 SOAT2, ACACT2, ACAT2, ARGP2 sterol O-acyltransferase 2 (EC:2.3.1.26) C00041026
128497 SPATA25, C20orf165, TSG23, dJ337O18.8 spermatogenesis associated 25 C00041026
285955 SPDYE1, Ringo1, SPDYE, WBSCR19 speedy/RINGO cell cycle regulator family member E1 C00041026
6696 SPP1, BNSP, BSPI, ETA-1, OPN secreted phosphoprotein 1 C00041026
10558 SPTLC1, HSAN1, HSN1, LBC1, LCB1, SPT1, SPTI serine palmitoyltransferase, long chain base subunit 1 (EC:2.3.1.50) C00041026
6427 SRSF2, PR264, SC-35, SC35, SFRS2, SFRS2A, SRp30b serine/arginine-rich splicing factor 2 C00041026
6756 SSX1, CT5.1, SSRC synovial sarcoma, X breakpoint 1 C00041026
9705 ST18, ZC2HC10, ZNF387 suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein) C00041026
9754 STARD8, ARHGAP38, DLC3, STARTGAP3 StAR-related lipid transfer (START) domain containing 8 C00041026
10228 STX6 syntaxin 6 C00041026
23512 SUZ12, CHET9, JJAZ1 SUZ12 polycomb repressive complex 2 subunit C00041026
23075 SWAP70, SWAP-70 SWAP switching B-cell complex 70kDa subunit C00041026
25949 SYF2, CBPIN, NTC31, P29, fSAP29 SYF2 pre-mRNA-splicing factor C00041026
8189 SYMPK, SPK, SYM symplekin C00041026
10492 SYNCRIP, GRY-RBP, GRYRBP, HNRNPQ, HNRPQ1, NSAP1, PP68, hnRNP-Q synaptotagmin binding, cytoplasmic RNA interacting protein C00041026
8148 TAF15, Npl3, RBP56, TAF2N, TAFII68 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa C00041026
6886 TAL1, SCL, TCL5, bHLHa17, tal-1 T-cell acute lymphocytic leukemia 1 C00041026
6943 TCF21, POD1, bHLHa23 transcription factor 21 C00041026
6947 TCN1, TC-1, TC1, TCI transcobalamin I (vitamin B12 binding protein, R binder family) C00041026
7068 THRB, C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2 thyroid hormone receptor, beta C00041026
38559 C00041026
114609 TIRAP, BACTS1, Mal, MyD88-2, wyatt toll-interleukin 1 receptor (TIR) domain containing adaptor protein C00041026
67356 C00041026
221468 TMEM217, C6orf128, dJ355M6.2 transmembrane protein 217 C00041026
25789 TMEM59L, BSMAP, C19orf4 transmembrane protein 59-like C00041026
81542 TMX1, PDIA11, TMX, TXNDC, TXNDC1 thioredoxin-related transmembrane protein 1 C00041026
126282 TNFAIP8L1, TIPE1 tumor necrosis factor, alpha-induced protein 8-like 1 C00041026
100528146 C00041026
54863 TOR4A, C9orf167 torsin family 4, member A C00041026
7159 TP53BP2, 53BP2, ASPP2, BBP, P53BP2, PPP1R13A tumor protein p53 binding protein, 2 C00041026
53373 TPCN1, TPC1 two pore segment channel 1 C00041026
23471 TRAM1, PNAS8, TRAM, TRAMP translocation associated membrane protein 1 C00041026
9697 TRAM2 translocation associated membrane protein 2 C00041026
54210 TREM1, CD354, TREM-1 triggering receptor expressed on myeloid cells 1 C00041026
54931 TRMT10C, HNYA, MRPP1, RG9MTD1 tRNA methyltransferase 10 homolog C (S. cerevisiae) C00041026
7103 TSPAN8, CO-029, TM4SF3 tetraspanin 8 C00041026
23508 TTC9, TTC9A tetratricopeptide repeat domain 9 C00041026
7272 TTK, CT96, ESK, MPH1, MPS1, MPS1L1, PYT TTK protein kinase (EC:2.7.12.1) C00041026
7289 TULP3, TUBL3 tubby like protein 3 C00041026
5756 TWF1, A6, PTK9 twinfilin actin-binding protein 1 C00041026
51619 UBE2D4, HBUCE1 ubiquitin-conjugating enzyme E2D 4 (putative) (EC:6.3.2.19) C00041026
7324 UBE2E1, UBCH6 ubiquitin-conjugating enzyme E2E 1 (EC:6.3.2.19) C00041026
9040 UBE2M, UBC-RS2, UBC12, hUbc12 ubiquitin-conjugating enzyme E2M (EC:6.3.2.19) C00041026
55148 UBR7, C14orf130 ubiquitin protein ligase E3 component n-recognin 7 (putative) C00041026
7353 UFD1L, UFD1 ubiquitin fusion degradation 1 like (yeast) C00041026
8633 UNC5C, UNC5H3 unc-5 homolog C (C. elegans) C00041026
7398 USP1, UBP ubiquitin specific peptidase 1 (EC:3.4.19.12) C00041026
84101 USP44 ubiquitin specific peptidase 44 (EC:3.4.19.12) C00041026
51118 UTP11L, CGI94 UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast) C00041026
80326 WNT10A, OODD, SSPS, STHAG4 wingless-type MMTV integration site family, member 10A C00041026
55689 YEATS2 YEATS domain containing 2 C00041026
55854 ZC3H15, HT010, LEREPO4, MSTP012 zinc finger CCCH-type containing 15 C00041026
253832 ZDHHC20, 4933421L13Rik, DHHC-20 zinc finger, DHHC-type containing 20 (EC:2.3.1.225) C00041026
79752 ZFAND1 zinc finger, AN1-type domain 1 C00041026
7745 ZKSCAN8, LD5-1, ZNF192, ZSCAN40 zinc finger with KRAB and SCAN domains 8 C00041026
84225 ZMYND15 zinc finger, MYND-type containing 15 C00041026
7705 ZNF146, OZF zinc finger protein 146 C00041026
84330 ZNF414, ZFP414 zinc finger protein 414 C00041026
220929 ZNF438, bA330O11.1 zinc finger protein 438 C00041026
158399 ZNF483, ZKSCAN16, ZSCAN48 zinc finger protein 483 C00041026
162968 ZNF497 zinc finger protein 497 C00041026
7783 ZP2, ZPA, Zp-2 zona pellucida glycoprotein 2 (sperm receptor) C00041026

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (19)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#614466 Coronary heart disease, susceptibility to, 6; chds6 P08254
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679

KEGG DISEASE (16)

KEGG name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00028 Choriocarcinoma P03956 (related)
P08253 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00479 Metaphyseal dysplasias P14780 (related)

Diseases related to CTD interactions

8 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D000236 Adenoma C00041026
D056486 Drug-Induced Liver Injury C00041026
D006099 Granuloma C00041026
D006965 Hyperplasia C00041026
D006984 Hypertrophy C00041026
D008114 Liver Neoplasms, Experimental C00041026
D011230 Precancerous Conditions C00041026
C572845 Thyroid cancer, follicular C00041026