KNApSAcK Metabolite C00011625
Metabolite
KNApSAcK Entry
| id | C00011625 |
|---|---|
| Name | ar-Tumerone / (S)-ar-Turmerone / (+)-ar-Turmerone |
| CAS RN | 532-65-0 |
| Standard InChI | InChI=1S/C15H20O/c1-11(2)9-15(16)10-13(4)14-7-5-12(3)6-8-14/h5-9,13H,10H2,1-4H3/t13-/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C15H20O/c1-11(2)9-15(16)10-13(4)14-7-5-12(3)6-8-14/h5-9,13H,10H2,1-4H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 1899 |
Link
ChEMBL
| By standard InChI | CHEMBL1668333 |
|---|---|
| By standard InChI Main Layer | CHEMBL506948 CHEMBL1668333 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN | C078098 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| Liliopsida | 4 |
Family
| family name | count |
|---|---|
| Zingiberaceae | 4 |
List (4)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Curcuma amada | 105371 | Zingiberaceae | Liliopsida | Viridiplantae |
| Curcuma domestica | 136217 | Zingiberaceae | Liliopsida | Viridiplantae |
| Curcuma longa | 136217 | Zingiberaceae | Liliopsida | Viridiplantae |
| Curcuma zedoaria | 136224 | Zingiberaceae | Liliopsida | Viridiplantae |
Human Protein / Gene in interaction
1 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P22303 | Acetylcholinesterase | Hydrolase | CHEMBL1668333 |
CHEMBL1671288
(1)
|
1 / 0 |
CTD interaction (7)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C078098 | 5243 |
ABCB1
ABC20 CD243 CLCS GP170 MDR1 P-GP PGY1 |
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) | ar-turmerone results in increased expression of ABCB1 mRNA |
increases expression
|
mRNA |
22181075
|
| C078098 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | ar-turmerone results in increased expression of BAX mRNA |
increases expression
|
mRNA |
19250610
|
| C078098 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | ar-turmerone results in increased expression of BAX protein |
increases expression
|
protein |
19250610
|
| C078098 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | ar-turmerone results in increased activity of CASP3 protein |
increases activity
|
protein |
19250610
|
| C078098 | 5468 |
PPARG
CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma |
peroxisome proliferator-activated receptor gamma | ar-turmerone binds to PPARG protein |
affects binding
|
protein |
15713005
|
| C078098 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | ar-turmerone results in increased expression of TP53 mRNA |
increases expression
|
mRNA |
19250610
|
| C078098 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | ar-turmerone results in increased expression of TP53 protein |
increases expression
|
protein |
19250610
|