KNApSAcK Metabolite C00001401
Metabolite
KNApSAcK Entry
| id | C00001401 |
|---|---|
| Name | p-Aminobenzoic acid |
| CAS RN | 150-13-0 |
| Standard InChI | InChI=1S/C7H7NO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H,9,10) |
| Standard InChI (Main Layer) | InChI=1S/C7H7NO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,8H2,(H,9,10) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 2192 |
Link
ChEMBL
| By standard InChI | CHEMBL542 |
|---|---|
| By standard InChI Main Layer | CHEMBL542 |
KEGG
| By LinkDB | C00568 |
|---|
CTD
| By CAS RN | D010129 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 1 |
Family
| family name | count |
|---|---|
| Brassicaceae | 1 |
| Enterobacteriaceae | 1 |
List (2)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Arabidopsis thaliana | 3702 | Brassicaceae | rosids | Viridiplantae |
| Escherichia coli | 562 | Enterobacteriaceae | Bacteria |
Human Protein / Gene in interaction
9 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P16473 | Thyrotropin receptor | Glycohormone receptor | CHEMBL542 |
CHEMBL1614281
(1)
CHEMBL1614361
(1)
|
3 / 2 |
| P51649 | Succinate-semialdehyde dehydrogenase, mitochondrial | Oxidoreductase | CHEMBL542 |
CHEMBL867028
(1)
|
1 / 1 |
| Q9UQ49 | Sialidase-3 | Enzyme | CHEMBL542 |
CHEMBL751097
(1)
|
0 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL542 |
CHEMBL2114780
(1)
|
0 / 0 |
| P11308 | Transcriptional regulator ERG | Unclassified protein | CHEMBL542 |
CHEMBL2114924
(1)
|
1 / 2 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL542 |
CHEMBL1794401
(1)
|
0 / 0 |
| P80404 | 4-aminobutyrate aminotransferase, mitochondrial | Transferase | CHEMBL542 |
CHEMBL867027
(1)
|
1 / 1 |
| P51580 | Thiopurine S-methyltransferase | Enzyme | CHEMBL542 |
CHEMBL814140
(1)
|
1 / 1 |
| P10275 | Androgen receptor | NR3C4 | CHEMBL542 |
CHEMBL1794321
(1)
CHEMBL1794560
(1)
|
3 / 4 |
CTD interaction (7)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D010129 | 1385 |
CREB1
CREB |
cAMP responsive element binding protein 1 | 4-Aminobenzoic Acid affects the expression of CREB1 mRNA |
affects expression
|
mRNA |
20385217
|
| D010129 | 9 |
NAT1
AAC1 MNAT NAT-1 NATI |
N-acetyltransferase 1 (arylamine N-acetyltransferase) (EC:2.3.1.5) | Dehydroepiandrosterone Sulfate inhibits the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid] |
decreases reaction
/ increases acetylation |
protein |
11470991
|
| D010129 | 9 |
NAT1
AAC1 MNAT NAT-1 NATI |
N-acetyltransferase 1 (arylamine N-acetyltransferase) (EC:2.3.1.5) | Dehydroepiandrosterone Sulfate promotes the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid] |
increases acetylation
/ increases reaction |
protein |
11470991
|
| D010129 | 9 |
NAT1
AAC1 MNAT NAT-1 NATI |
N-acetyltransferase 1 (arylamine N-acetyltransferase) (EC:2.3.1.5) | NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid |
increases acetylation
|
protein |
11470991
15627487 15880531 16003948 |
| D010129 | 9 |
NAT1
AAC1 MNAT NAT-1 NATI |
N-acetyltransferase 1 (arylamine N-acetyltransferase) (EC:2.3.1.5) | Pentachlorophenol inhibits the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid] |
decreases reaction
/ increases acetylation |
protein |
11470991
|
| D010129 | 4790 |
NFKB1
EBP-1 KBF1 NF-kB1 NF-kappa-B NF-kappaB NFKB-p105 NFKB-p50 NFkappaB p105 p50 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 4-Aminobenzoic Acid affects the expression of NFKB1 mRNA |
affects expression
|
mRNA |
20385217
|
| D010129 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | 4-Aminobenzoic Acid affects the expression of TNF mRNA |
affects expression
|
mRNA |
20385217
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (10)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #612219 | Ewing sarcoma; es |
P11308
|
| #613163 | Gaba-transaminase deficiency |
P80404
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #271980 | Succinic semialdehyde dehydrogenase deficiency; ssadhd |
P51649
|
| #610460 | Thiopurine s-methyltransferase deficiency |
P51580
|
KEGG DISEASE (10)
| KEGG | disease name | UniProt |
|---|---|---|
| H00024 | Prostate cancer |
P10275
(related)
P11308 (related) |
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00035 | Ewing's sarcoma |
P11308
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00964 | Thiopurine S-methyltransferase deficiency (TPMT deficiency) |
P51580
(related)
|
| H00835 | Succinic semialdehyde dehydrogenase (SSADH) deficiency |
P51649
(related)
|
| H01257 | GABA-transaminase deficiency |
P80404
(related)
|