KNApSAcK Metabolite C00001495
Metabolite
KNApSAcK Entry
| id | C00001495 |
|---|---|
| Name | Cordycepin |
| CAS RN | 73-03-0 |
| Standard InChI | InChI=1S/C10H13N5O3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(17)1-5(2-16)18-10/h3-6,10,16-17H,1-2H2,(H2,11,12,13)/t5-,6?,10+/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C10H13N5O3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(17)1-5(2-16)18-10/h3-6,10,16-17H,1-2H2,(H2,11,12,13) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 1060 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL42814 CHEMBL305686 CHEMBL1563465 |
KEGG
| By LinkDB | C08431 |
|---|
CTD
| By CAS RN | C058120 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Aspergillaceae | 1 |
| Cordycipitaceae | 1 |
List (2)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Aspergillus nidulans | 162425 | Aspergillaceae | Fungi | |
| Cordyceps militaris | 73501 | Cordycipitaceae | Fungi |
Human Protein / Gene in interaction
1 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | CHEMBL1563465 |
CHEMBL1614240
(1)
|
0 / 0 |
CTD interaction (19)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C058120 | 572 |
BAD
BBC2 BCL2L8 |
BCL2-associated agonist of cell death | Acetylcysteine inhibits the reaction [cordycepin results in increased expression of BAD protein] |
decreases reaction
/ increases expression |
protein |
21310227
|
| C058120 | 572 |
BAD
BBC2 BCL2L8 |
BCL2-associated agonist of cell death | cordycepin results in increased expression of BAD protein |
increases expression
|
protein |
21310227
|
| C058120 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | Acetylcysteine inhibits the reaction [cordycepin results in increased expression of BAX protein] |
decreases reaction
/ increases expression |
protein |
21310227
|
| C058120 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | cordycepin affects the localization of BAX protein |
affects localization
|
protein |
21933677
|
| C058120 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | cordycepin results in increased expression of BAX protein |
increases expression
|
protein |
21310227
|
| C058120 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of BCL2 protein] |
decreases expression
/ decreases reaction |
protein |
21310227
|
| C058120 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | cordycepin results in decreased expression of BCL2 protein |
decreases expression
|
protein |
21310227
|
| C058120 | 598 |
BCL2L1
BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS |
BCL2-like 1 | Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of BCL2L1 protein] |
decreases expression
/ decreases reaction |
protein |
21310227
|
| C058120 | 598 |
BCL2L1
BCL-XL/S BCL2L BCLX BCLXL BCLXS Bcl-X PPP1R52 bcl-xL bcl-xS |
BCL2-like 1 | cordycepin results in decreased expression of BCL2L1 protein |
decreases expression
|
protein |
21310227
|
| C058120 | 637 |
BID
FP497 |
BH3 interacting domain death agonist | Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of BID protein] |
decreases expression
/ decreases reaction |
protein |
21310227
|
| C058120 | 637 |
BID
FP497 |
BH3 interacting domain death agonist | cordycepin results in decreased expression of BID protein |
decreases expression
|
protein |
21310227
|
| C058120 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Acetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
21310227
|
| C058120 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | cordycepin results in increased activity of CASP3 protein |
increases activity
|
protein |
21310227
21933677 |
| C058120 | 841 |
CASP8
ALPS2B CAP4 Casp-8 FLICE MACH MCH5 |
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) | Acetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP8 protein] |
decreases reaction
/ increases activity |
protein |
21310227
|
| C058120 | 841 |
CASP8
ALPS2B CAP4 Casp-8 FLICE MACH MCH5 |
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) | cordycepin results in increased activity of CASP8 protein |
increases activity
|
protein |
21310227
|
| C058120 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | Acetylcysteine inhibits the reaction [cordycepin results in increased activity of CASP9 protein] |
decreases reaction
/ increases activity |
protein |
21310227
|
| C058120 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | cordycepin results in increased activity of CASP9 protein |
increases activity
|
protein |
21310227
21933677 |
| C058120 | 331 |
XIAP
API3 BIRC4 IAP-3 ILP1 MIHA XLP2 hIAP-3 hIAP3 |
X-linked inhibitor of apoptosis | Acetylcysteine inhibits the reaction [cordycepin results in decreased expression of XIAP protein] |
decreases expression
/ decreases reaction |
protein |
21310227
|
| C058120 | 331 |
XIAP
API3 BIRC4 IAP-3 ILP1 MIHA XLP2 hIAP-3 hIAP3 |
X-linked inhibitor of apoptosis | cordycepin results in decreased expression of XIAP protein |
decreases expression
|
protein |
21310227
|