KNApSAcK Metabolite C00016108
Metabolite
KNApSAcK Entry
| id | C00016108 |
|---|---|
| Name | Topostatin / Topostatin (Thermomonospora alba) |
| CAS RN | 219774-62-6 |
| Standard InChI | InChI=1S/C36H58N4O11S/c1-8-9-10-11-12-13-22(2)14-15-23(3)16-18-29(41)24(4)17-19-30-26(6)34(44)39-27(7)35(45)38-21-25(5)33(43)40-28(36(46)50-30)20-31(32(37)42)51-52(47,48)49/h15-16,18,22,24-26,28,30-31H,7-14,17,19-21H2,1-6H3,(H2,37,42)(H,38,45)(H,39,44)(H,40,43)(H,47,48,49)/b18-16+,23-15+ |
| Standard InChI (Main Layer) | InChI=1S/C36H58N4O11S/c1-8-9-10-11-12-13-22(2)14-15-23(3)16-18-29(41)24(4)17-19-30-26(6)34(44)39-27(7)35(45)38-21-25(5)33(43)40-28(36(46)50-30)20-31(32(37)42)51-52(47,48)49/h15-16,18,22,24-26,28,30-31H,7-14,17,19-21H2,1-6H3,(H2,37,42)(H,38,45)(H,39,44)(H,40,43)(H,47,48,49) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 8358 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL505529 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Thermomonosporaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Thermomonospora alba No.1520 | 2019 | Thermomonosporaceae | Bacteria |
Human Protein / Gene in interaction
3 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P11387 | DNA topoisomerase 1 | Isomerase | CHEMBL505529 |
CHEMBL996007
(1)
CHEMBL996008
(1)
CHEMBL996009 (1) |
0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | CHEMBL505529 |
CHEMBL996010
(1)
CHEMBL996011
(1)
|
0 / 0 |
| O14746 | Telomerase reverse transcriptase | Enzyme | CHEMBL505529 |
CHEMBL990278
(1)
|
5 / 5 |
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (5)
| OMIM | preferred title | UniProt |
|---|---|---|
| #609135 | Aplastic anemia |
O14746
|
| #613989 | Dyskeratosis congenita, autosomal dominant, 2; dkca2 |
O14746
|
| #615134 | Melanoma, cutaneous malignant, susceptibility to, 9; cmm9 |
O14746
|
| #614742 | Pulmonary fibrosis and/or bone marrow failure, telomere-related, 1; pfbmft1 |
O14746
|
| #178500 | Pulmonary fibrosis, idiopathic; ipf |
O14746
|