KNApSAcK Metabolite C00017062
Metabolite
KNApSAcK Entry
| id | C00017062 |
|---|---|
| Name | RF 1023B / Trapoxin B |
| CAS RN | 133155-90-5 |
| Standard InChI | InChI=1S/C33H40N4O6/c38-28(29-21-43-29)17-9-3-8-15-24-30(39)35-25(19-22-11-4-1-5-12-22)31(40)36-26(20-23-13-6-2-7-14-23)33(42)37-18-10-16-27(37)32(41)34-24/h1-2,4-7,11-14,24-27,29H,3,8-10,15-21H2,(H,34,41)(H,35,39)(H,36,40)/t24-,25-,26-,27+,29-/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C33H40N4O6/c38-28(29-21-43-29)17-9-3-8-15-24-30(39)35-25(19-22-11-4-1-5-12-22)31(40)36-26(20-23-13-6-2-7-14-23)33(42)37-18-10-16-27(37)32(41)34-24/h1-2,4-7,11-14,24-27,29H,3,8-10,15-21H2,(H,34,41)(H,35,39)(H,36,40) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 567 |
Link
ChEMBL
| By standard InChI | CHEMBL2000089 |
|---|---|
| By standard InChI Main Layer | CHEMBL2000089 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN | C067071 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Tubeufiaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Helicoma ambiens RF-1023 | 314148 | Tubeufiaceae | Fungi |
Human Protein / Gene in interaction
11 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| Q13547 | Histone deacetylase 1 | Hydrolase | CHEMBL2000089 |
CHEMBL686829
(1)
CHEMBL694905
(1)
CHEMBL695138 (1) CHEMBL695139 (1) CHEMBL1036437 (1) |
0 / 0 |
| Q9BY41 | Histone deacetylase 8 | Hydrolase | CHEMBL2000089 |
CHEMBL686829
(1)
CHEMBL694905
(1)
CHEMBL695138 (1) CHEMBL695139 (1) |
2 / 0 |
| Q969S8 | Histone deacetylase 10 | Hydrolase | CHEMBL2000089 |
CHEMBL686829
(1)
CHEMBL694905
(1)
CHEMBL695138 (1) CHEMBL695139 (1) |
0 / 0 |
| O15379 | Histone deacetylase 3 | Hydrolase | CHEMBL2000089 |
CHEMBL686829
(1)
CHEMBL694905
(1)
CHEMBL695138 (1) CHEMBL695139 (1) |
0 / 0 |
| P56524 | Histone deacetylase 4 | Hydrolase | CHEMBL2000089 |
CHEMBL686829
(1)
CHEMBL694905
(1)
CHEMBL695138 (1) CHEMBL695139 (1) |
1 / 1 |
| Q8WUI4 | Histone deacetylase 7 | Hydrolase | CHEMBL2000089 |
CHEMBL686829
(1)
CHEMBL694905
(1)
CHEMBL695138 (1) CHEMBL695139 (1) |
0 / 0 |
| Q9UQL6 | Histone deacetylase 5 | Hydrolase | CHEMBL2000089 |
CHEMBL686829
(1)
CHEMBL694905
(1)
CHEMBL695138 (1) CHEMBL695139 (1) |
0 / 0 |
| Q9UKV0 | Histone deacetylase 9 | Hydrolase | CHEMBL2000089 |
CHEMBL686829
(1)
CHEMBL694905
(1)
CHEMBL695138 (1) CHEMBL695139 (1) |
0 / 0 |
| Q92769 | Histone deacetylase 2 | Hydrolase | CHEMBL2000089 |
CHEMBL686829
(1)
CHEMBL694905
(1)
CHEMBL695138 (1) CHEMBL695139 (1) |
0 / 0 |
| Q9UBN7 | Histone deacetylase 6 | Hydrolase | CHEMBL2000089 |
CHEMBL686829
(1)
CHEMBL694905
(1)
CHEMBL695138 (1) CHEMBL695139 (1) |
0 / 0 |
| Q96DB2 | Histone deacetylase 11 | Hydrolase | CHEMBL2000089 |
CHEMBL686829
(1)
CHEMBL694905
(1)
CHEMBL695138 (1) CHEMBL695139 (1) |
0 / 0 |
CTD interaction (3)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C067071 | 3065 |
HDAC1
GON-10 HD1 RPD3 RPD3L1 |
histone deacetylase 1 (EC:3.5.1.98) | trapoxin B results in decreased activity of HDAC1 protein |
decreases activity
|
protein |
15930892
|
| C067071 | 8841 |
HDAC3
HD3 RPD3 RPD3-2 |
histone deacetylase 3 (EC:3.5.1.98) | trapoxin B results in decreased activity of HDAC3 protein |
decreases activity
|
protein |
15930892
|
| C067071 | 10013 |
HDAC6
CPBHM HD6 |
histone deacetylase 6 (EC:3.5.1.98) | trapoxin B results in decreased activity of HDAC6 protein |
decreases activity
|
protein |
15930892
|