PCIDB

KNApSAcK Metabolite C00001716

Metabolite

KNApSAcK Entry

id C00001716
Name Ellipticine
CAS RN 519-23-3
Standard InChI InChI=1S/C17H14N2/c1-10-14-9-18-8-7-12(14)11(2)17-16(10)13-5-3-4-6-15(13)19-17/h3-9,19H,1-2H3
Standard InChI (Main Layer) InChI=1S/C17H14N2/c1-10-14-9-18-8-7-12(14)11(2)17-16(10)13-5-3-4-6-15(13)19-17/h3-9,19H,1-2H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 1510

Link

ChEMBL

By standard InChI CHEMBL123
By standard InChI Main Layer CHEMBL123

KEGG

By LinkDB C09154

CTD

By CAS RN C034192

Human Protein / Gene in interaction

68 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL123 CHEMBL1614110 (2) CHEMBL1741321 (1)
1 / 0
P42345 Serine/threonine-protein kinase mTOR Enzyme CHEMBL123 CHEMBL1614316 (1) CHEMBL1613805 (1)
CHEMBL1614009 (1)
0 / 0
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL123 CHEMBL1613992 (2) CHEMBL1613995 (2)
7 / 44
Q16637 Survival motor neuron protein Unclassified protein CHEMBL123 CHEMBL1613842 (3)
4 / 2
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL123 CHEMBL1738312 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL123 CHEMBL1794367 (1) CHEMBL2114784 (2)
1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL123 CHEMBL1794499 (1)
2 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL123 CHEMBL1737859 (1) CHEMBL2114744 (1)
0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL123 CHEMBL1794573 (1)
2 / 2
P06746 DNA polymerase beta Enzyme CHEMBL123 CHEMBL1614079 (2)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL123 CHEMBL1614472 (1)
1 / 1
P29466 Caspase-1 C14 CHEMBL123 CHEMBL1614158 (1)
0 / 0
P26599 Polypyrimidine tract-binding protein 1 Unclassified protein CHEMBL123 CHEMBL1614230 (1) CHEMBL1614037 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL123 CHEMBL1614310 (1) CHEMBL1614544 (3)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL123 CHEMBL1614361 (1)
3 / 2
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL123 CHEMBL1614027 (1) CHEMBL1741325 (1)
0 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL123 CHEMBL1614522 (1)
1 / 2
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL123 CHEMBL1614166 (1)
1 / 0
O95180 Voltage-dependent T-type calcium channel subunit alpha-1H CACN alpha-2 delta CHEMBL123 CHEMBL1737966 (1)
1 / 0
P11387 DNA topoisomerase 1 Isomerase CHEMBL123 CHEMBL896370 (1) CHEMBL1645637 (1)
0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase CHEMBL123 CHEMBL939345 (1) CHEMBL993356 (1)
CHEMBL993357 (1) CHEMBL1065961 (1)
0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL123 CHEMBL1613800 (2)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL123 CHEMBL1614458 (3)
0 / 0
P68871 Hemoglobin subunit beta Secreted protein CHEMBL123 CHEMBL1614225 (2)
4 / 4
P17405 Sphingomyelin phosphodiesterase Enzyme CHEMBL123 CHEMBL1794495 (1)
2 / 2
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL123 CHEMBL1614456 (3) CHEMBL1613803 (3)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL123 CHEMBL1613922 (1) CHEMBL1794486 (2)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL123 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL123 CHEMBL1613941 (1) CHEMBL1738636 (1)
CHEMBL2114843 (2) CHEMBL2114780 (2)
0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein CHEMBL123 CHEMBL1613838 (1)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL123 CHEMBL1794569 (2)
1 / 1
P42226 Signal transducer and activator of transcription 6 Unclassified protein CHEMBL123 CHEMBL1614338 (3) CHEMBL1613945 (3)
CHEMBL1614070 (3)
0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL123 CHEMBL1614257 (2) CHEMBL1614410 (2)
CHEMBL1614531 (2)
1 / 3
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL123 CHEMBL1738610 (1) CHEMBL1794401 (1)
0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme CHEMBL123 CHEMBL1963863 (1) CHEMBL2114898 (1)
CHEMBL2114934 (1)
0 / 0
P11021 78 kDa glucose-regulated protein Unclassified protein CHEMBL123 CHEMBL1963893 (2)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL123 CHEMBL1794467 (2)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL123 CHEMBL963779 (1)
0 / 1
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme CHEMBL123 CHEMBL1614252 (1)
2 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL123 CHEMBL1614521 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL123 CHEMBL1741322 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL123 CHEMBL1613910 (2)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL123 CHEMBL1614038 (2)
2 / 2
O15118 Niemann-Pick C1 protein Unclassified protein CHEMBL123 CHEMBL1614342 (2)
1 / 1
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL123 CHEMBL1614171 (1)
5 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL123 CHEMBL1738588 (1) CHEMBL1738675 (1)
CHEMBL1737868 (1)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL123 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P55210 Caspase-7 C14 CHEMBL123 CHEMBL1613779 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL123 CHEMBL1613777 (2) CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL123 CHEMBL1614108 (2) CHEMBL1613886 (2)
CHEMBL1741324 (1)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL123 CHEMBL1794483 (1)
0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor CHEMBL123 CHEMBL1614052 (1)
1 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL123 CHEMBL1614283 (1) CHEMBL1614466 (1)
CHEMBL1614211 (3)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL123 CHEMBL1614421 (2) CHEMBL1614502 (2)
4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein CHEMBL123 CHEMBL1738402 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL123 CHEMBL1737980 (1) CHEMBL1738184 (1)
0 / 0
P10721 Mast/stem cell growth factor receptor Kit Pdgfr CHEMBL123 CHEMBL880421 (1) CHEMBL883229 (1)
CHEMBL883395 (1) CHEMBL873572 (1)
4 / 4
P06239 Tyrosine-protein kinase Lck Src CHEMBL123 CHEMBL939225 (1)
0 / 1
O43603 Galanin receptor type 2 Galanin receptor CHEMBL123 CHEMBL1614350 (1) CHEMBL1614422 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL123 CHEMBL1794536 (3)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL123 CHEMBL1613914 (3)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL123 CHEMBL1614330 (1) CHEMBL1613829 (1)
CHEMBL1613928 (1)
0 / 0
P40225 Thrombopoietin Unclassified protein CHEMBL123 CHEMBL1614086 (1) CHEMBL1614034 (1)
1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL123 CHEMBL1738442 (3)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL123 CHEMBL1614364 (3) CHEMBL1738394 (1)
1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL123 CHEMBL2354311 (1)
1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme CHEMBL123 CHEMBL1963966 (1) CHEMBL2114859 (1)
CHEMBL2114734 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL123 CHEMBL1614257 (2) CHEMBL1614531 (2)
2 / 5

CTD interaction (46)

compound gene gene name gene description interaction interaction type form reference
pmid
C034192 581 BAX
BCL2L4
BCL2-associated X protein ellipticine results in increased expression of BAX protein increases expression
protein 16027529
C034192 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 ellipticine results in decreased expression of BCL2 protein decreases expression
protein 16027529
C034192 637 BID
FP497
BH3 interacting domain death agonist ellipticine results in decreased expression of and results in increased cleavage of BID protein decreases expression
/ increases cleavage
protein 21843585
C034192 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Acetylcysteine inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein] decreases reaction
/ increases activity
/ increases cleavage
protein 21843585
C034192 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein] decreases reaction
/ increases activity
/ increases cleavage
protein 21843585
C034192 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein] decreases reaction
/ increases activity
/ increases cleavage
protein 21843585
C034192 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) ellipticine results in increased activity of CASP3 protein increases activity
protein 16027529
C034192 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) ellipticine results in increased cleavage of and results in increased activity of CASP3 protein increases activity
/ increases cleavage
protein 21843585
C034192 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) U 0126 inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP3 protein] decreases reaction
/ increases activity
/ increases cleavage
protein 21843585
C034192 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Acetylcysteine inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein] decreases reaction
/ increases activity
/ increases cleavage
protein 21843585
C034192 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein] decreases reaction
/ increases activity
/ increases cleavage
protein 21843585
C034192 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein] decreases reaction
/ increases activity
/ increases cleavage
protein 21843585
C034192 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) ellipticine results in increased cleavage of and results in increased activity of CASP7 protein increases activity
/ increases cleavage
protein 21843585
C034192 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) U 0126 inhibits the reaction [ellipticine results in increased cleavage of and results in increased activity of CASP7 protein] decreases reaction
/ increases activity
/ increases cleavage
protein 21843585
C034192 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) ellipticine results in increased cleavage of and results in increased activity of CASP8 protein increases activity
/ increases cleavage
protein 21843585
C034192 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) ellipticine results in increased activity of CASP9 protein increases activity
protein 16027529
C034192 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) ellipticine results in increased cleavage of and results in increased activity of CASP9 protein increases activity
/ increases cleavage
protein 21843585
C034192 891 CCNB1
CCNB
cyclin B1 ellipticine results in decreased expression of CCNB1 protein decreases expression
protein 16027529
C034192 891 CCNB1
CCNB
cyclin B1 ellipticine results in increased expression of CCNB1 protein increases expression
protein 21843585
C034192 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 ellipticine results in decreased expression of CCND1 protein decreases expression
protein 21843585
C034192 995 CDC25C
CDC25
PPP1R60
cell division cycle 25C (EC:3.1.3.48) ellipticine results in decreased expression of CDC25C protein decreases expression
protein 16027529
C034192 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) ellipticine results in decreased expression of and results in increased phosphorylation of CDK1 protein decreases expression
/ increases phosphorylation
protein 16027529
C034192 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) ellipticine results in decreased expression of CDKN1B protein decreases expression
protein 21843585
C034192 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) CYP1A1 protein results in increased metabolism of ellipticine increases metabolic processing
protein 22917556
C034192 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) ellipticine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] decreases reaction
/ increases activity
protein 18493746
C034192 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) CYP1A2 protein results in increased metabolism of ellipticine increases metabolic processing
protein 22917556
C034192 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) ellipticine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] decreases reaction
/ increases activity
protein 18493746
C034192 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) CYP1B1 protein results in increased metabolism of ellipticine increases metabolic processing
protein 22917556
C034192 1557 CYP2C19
CPCJ
CYP2C
P450C2C
P450IIC19
cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) CYP2C19 protein results in increased metabolism of ellipticine increases metabolic processing
protein 22917556
C034192 1559 CYP2C9
CPC9
CYP2C
CYP2C10
CYPIIC9
P450IIC9
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) CYP2C9 protein mutant form results in increased metabolism of ellipticine increases metabolic processing
protein 22917556
C034192 1565 CYP2D6
CPD6
CYP2D
CYP2D7AP
CYP2D7BP
CYP2D7P2
CYP2D8P2
CYP2DL1
CYPIID6
P450-DB1
P450C2D
P450DB1
cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) CYP2D6 protein mutant form results in increased metabolism of ellipticine increases metabolic processing
protein 22917556
C034192 1571 CYP2E1
CPE1
CYP2E
P450-J
P450C2E
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) CYP2E1 protein results in increased metabolism of ellipticine increases metabolic processing
protein 22917556
C034192 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased oxidation of ellipticine affects cotreatment
/ increases oxidation
protein 22390216
C034192 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) CYP3A4 protein results in increased metabolism of ellipticine increases metabolic processing
protein 22917556
C034192 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Acetylcysteine inhibits the reaction [ellipticine results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 21843585
C034192 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 21843585
C034192 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) ellipticine results in increased phosphorylation of MAPK1 protein increases phosphorylation
protein 21843585
C034192 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Acetylcysteine inhibits the reaction [ellipticine results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 21843585
C034192 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Butylated Hydroxyanisole inhibits the reaction [ellipticine results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 21843585
C034192 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) ellipticine results in increased phosphorylation of MAPK3 protein increases phosphorylation
protein 21843585
C034192 4193 MDM2
ACTFS
HDMX
hdm2
MDM2 oncogene, E3 ubiquitin protein ligase MDM2 promoter SNP results in decreased susceptibility to ellipticine decreases response to substance
promoter 17575151
C034192 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) ellipticine results in increased cleavage of PARP1 protein increases cleavage
protein 21843585
C034192 5447 POR
CPR
CYPOR
P450R
P450 (cytochrome) oxidoreductase (EC:1.6.2.4) [CYP3A4 protein co-treated with POR protein co-treated with NADP] results in increased oxidation of ellipticine affects cotreatment
/ increases oxidation
protein 22390216
C034192 7155 TOP2B
TOPIIB
top2beta
topoisomerase (DNA) II beta 180kDa (EC:5.99.1.3) TOP2B protein mutant form results in decreased susceptibility to ellipticine decreases response to substance
protein 16239602
C034192 7155 TOP2B
TOPIIB
top2beta
topoisomerase (DNA) II beta 180kDa (EC:5.99.1.3) TOP2B protein mutant form results in increased susceptibility to ellipticine increases response to substance
protein 15322234
C034192 331 XIAP
API3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
X-linked inhibitor of apoptosis ellipticine results in decreased expression of XIAP protein decreases expression
protein 16027529
21843585

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (71)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#613985 Beta-thalassemia P68871
#603902 Beta-thalassemia, dominant inclusion body type P68871
#210900 Bloom syndrome; blm P54132
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P18054
P84022
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#611942 Epilepsy, childhood absence, susceptibility to, 6; eca6 O95180
#133239 Esophageal cancer P04637
P18054
#600274 Frontotemporal dementia; ftd P10636
#606764 Gastrointestinal stromal tumor; gist P10721
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#140700 Heinz body anemias P68871
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#601626 Leukemia, acute myeloid; aml P10721
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#257220 Niemann-pick disease, type c1; npc1 O15118
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#172800 Piebald trait; pbt P10721
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#609620 Short qt syndrome 1; sqt1 Q12809
#603903 Sickle cell anemia P68871
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#273300 Testicular germ cell tumor; tgct P10721
#187950 Thrombocythemia 1; thcyt1 P40225
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (85)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
P68871 (marker)
H00022 Bladder cancer P04637 (related)
P68871 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00003 Acute myeloid leukemia (AML) P10721 (related)
P10721 (marker)
H00170 Piebaldism P10721 (related)
H00023 Testicular cancer P10721 (marker)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00228 Thalassemia P68871 (related)
H00229 Sickle cell anemia (SCA) P68871 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

4 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D001943 C034192 Breast Neoplasms therapeutic
21843585
D010051 C034192 Ovarian Neoplasms therapeutic
21843585
D013964 C034192 Thyroid Neoplasms therapeutic
21843585
D014202 C034192 Tremor therapeutic
3088650