KNApSAcK Metabolite C00017237
Metabolite
KNApSAcK Entry
| id | C00017237 |
|---|---|
| Name | RK 1409 / BMY 41950 / 7-Oxostaurosporine |
| CAS RN | 125035-83-8 |
| Standard InChI | InChI=1S/C28H24N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,29H,12H2,1-3H3,(H,30,33,34) |
| Standard InChI (Main Layer) | InChI=1S/C28H24N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,29H,12H2,1-3H3,(H,30,33,34) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 251 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL337026 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Streptomycetaceae | 3 |
List (3)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Streptomyces hygroscopicus C39280-450-9 (ATCC53730) | 1883 | Streptomycetaceae | Bacteria | |
| Streptomyces platensis subsp. malvinus RK-1409 | 1883 | Streptomycetaceae | Bacteria | |
| Streptomyces staurosporeus AM-2282 | 1883 | Streptomycetaceae | Bacteria |
Human Protein / Gene in interaction
16 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | CHEMBL337026 |
CHEMBL677890
(1)
|
1 / 11 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | CHEMBL337026 |
CHEMBL806345
(1)
|
0 / 0 |
| Q05513 | Protein kinase C zeta type | Iota | CHEMBL337026 |
CHEMBL767434
(1)
|
0 / 0 |
| Q04759 | Protein kinase C theta type | Delta | CHEMBL337026 |
CHEMBL767434
(1)
|
0 / 1 |
| Q02156 | Protein kinase C epsilon type | Eta | CHEMBL337026 |
CHEMBL767434
(1)
|
0 / 0 |
| O94806 | Serine/threonine-protein kinase D3 | Pkd | CHEMBL337026 |
CHEMBL767434
(1)
|
0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | CHEMBL337026 |
CHEMBL767434
(1)
|
0 / 0 |
| Q05655 | Protein kinase C delta type | Delta | CHEMBL337026 |
CHEMBL767434
(1)
|
0 / 0 |
| P05129 | Protein kinase C gamma type | Alpha | CHEMBL337026 |
CHEMBL767434
(1)
|
1 / 1 |
| P05771 | Protein kinase C beta type | Alpha | CHEMBL337026 |
CHEMBL767434
(1)
|
0 / 0 |
| P24723 | Protein kinase C eta type | Eta | CHEMBL337026 |
CHEMBL767434
(1)
|
1 / 0 |
| P41743 | Protein kinase C iota type | Iota | CHEMBL337026 |
CHEMBL767434
(1)
|
0 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | CHEMBL337026 |
CHEMBL767434
(1)
|
0 / 0 |
| P22694 | cAMP-dependent protein kinase catalytic subunit beta | Pka | CHEMBL337026 |
CHEMBL768001
(1)
|
0 / 0 |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | Pka | CHEMBL337026 |
CHEMBL768001
(1)
|
0 / 0 |
| P22612 | cAMP-dependent protein kinase catalytic subunit gamma | Pka | CHEMBL337026 |
CHEMBL768001
(1)
|
0 / 0 |
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (3)
| OMIM | preferred title | UniProt |
|---|---|---|
| #211980 | Lung cancer |
P00533
|
| #605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
| #601367 | Stroke, ischemic |
P24723
|
KEGG DISEASE (10)
| KEGG | disease name | UniProt |
|---|---|---|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
|
| H00018 | Gastric cancer |
P00533
(related)
|
| H00022 | Bladder cancer |
P00533
(related)
|
| H00028 | Choriocarcinoma |
P00533
(related)
|
| H00030 | Cervical cancer |
P00533
(related)
|
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
|
| H00408 | Type I diabetes mellitus |
Q04759
(related)
|