KNApSAcK Metabolite C00001757
Metabolite
KNApSAcK Entry
| id | C00001757 |
|---|---|
| Name | Physostigmine |
| CAS RN | 57-47-6 |
| Standard InChI | InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19) |
Cluster
| Phytochemical cluster | No. 4 |
|---|---|
| KCF-S cluster | No. 2568 |
Link
ChEMBL
| By standard InChI | CHEMBL94 |
|---|---|
| By standard InChI Main Layer | CHEMBL94 CHEMBL11773 CHEMBL306319 CHEMBL76640 CHEMBL382351 CHEMBL1243269 |
KEGG
| By LinkDB | C06535 |
|---|
CTD
| By CAS RN | D010830 |
|---|
Species
Summary
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Physostigma venenosum | 271807 | Fabaceae | rosids | Viridiplantae |
Human Protein / Gene in interaction
109 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL94 CHEMBL1243269 |
CHEMBL1614110
(4)
CHEMBL1741321
(3)
CHEMBL1909136 (2) |
1 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | CHEMBL94 |
CHEMBL1613842
(1)
|
4 / 2 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | CHEMBL1243269 |
CHEMBL1794499
(1)
|
2 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | CHEMBL94 |
CHEMBL1909139
(2)
|
0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | CHEMBL94 |
CHEMBL1909131
(2)
|
0 / 3 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | CHEMBL94 |
CHEMBL1909190
(2)
|
2 / 2 |
| P08246 | Neutrophil elastase | S1A | CHEMBL94 |
CHEMBL1909195
(2)
|
2 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | CHEMBL94 |
CHEMBL1909215
(2)
|
0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | CHEMBL94 |
CHEMBL1909201
(2)
|
0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | CHEMBL94 |
CHEMBL1909176
(2)
|
0 / 0 |
| P29466 | Caspase-1 | C14 | CHEMBL94 |
CHEMBL1909193
(2)
|
0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | CHEMBL94 |
CHEMBL1909198
(2)
|
0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | CHEMBL94 |
CHEMBL1909199
(2)
|
0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | CHEMBL94 |
CHEMBL1909197
(2)
|
2 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL94 |
CHEMBL1614544
(1)
|
11 / 10 |
| P00918 | Carbonic anhydrase 2 | Lyase | CHEMBL94 |
CHEMBL1909123
(2)
|
1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | CHEMBL94 |
CHEMBL1909092
(2)
|
0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | CHEMBL94 |
CHEMBL1909169
(2)
|
1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | CHEMBL94 |
CHEMBL1909157
(2)
|
0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | CHEMBL94 |
CHEMBL1909156
(2)
|
0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | CHEMBL94 |
CHEMBL1909143
(2)
|
1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | CHEMBL94 |
CHEMBL1909174
(2)
|
0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | CHEMBL94 |
CHEMBL1909090
(2)
|
0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | CHEMBL94 |
CHEMBL1909093
(2)
|
0 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | CHEMBL94 |
CHEMBL1909127
(2)
|
0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | CHEMBL94 |
CHEMBL1909204
(2)
|
0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | CHEMBL94 |
CHEMBL1909202
(2)
|
0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL94 CHEMBL1243269 |
CHEMBL1741325
(3)
CHEMBL1909135
(2)
|
0 / 1 |
| P54132 | Bloom syndrome protein | Enzyme | CHEMBL94 |
CHEMBL1614522
(1)
CHEMBL1614067
(1)
|
1 / 2 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | CHEMBL94 |
CHEMBL1909203
(2)
|
1 / 11 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | CHEMBL94 |
CHEMBL1909140
(2)
|
2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | CHEMBL94 |
CHEMBL1909130
(2)
|
0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | CHEMBL94 |
CHEMBL1909120
(2)
|
0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | CHEMBL94 |
CHEMBL1909181
(2)
|
0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | CHEMBL94 |
CHEMBL1909164
(2)
|
0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | CHEMBL94 |
CHEMBL1909214
(2)
|
0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | CHEMBL94 |
CHEMBL1909175
(2)
|
0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | CHEMBL94 |
CHEMBL1909096
(2)
|
1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | CHEMBL94 |
CHEMBL1909118
(2)
|
0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | CHEMBL94 |
CHEMBL1909166
(2)
|
1 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL94 |
CHEMBL1614458
(1)
|
0 / 0 |
| P38571 | Lysosomal acid lipase/cholesteryl ester hydrolase | Enzyme | CHEMBL94 |
CHEMBL1119695
(1)
|
1 / 1 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | CHEMBL94 |
CHEMBL1909133
(2)
|
0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | CHEMBL1243269 |
CHEMBL1614456
(1)
CHEMBL1613803
(1)
|
0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | CHEMBL94 |
CHEMBL1738606
(1)
|
0 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL94 |
CHEMBL2114780
(1)
|
0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | CHEMBL94 |
CHEMBL1909158
(2)
|
0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | CHEMBL94 |
CHEMBL1909088
(2)
|
0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | CHEMBL94 |
CHEMBL1909142
(2)
|
0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | CHEMBL94 |
CHEMBL1909101
(2)
|
0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | CHEMBL94 |
CHEMBL1909141
(2)
|
1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | CHEMBL94 |
CHEMBL1909180
(2)
|
0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | CHEMBL94 |
CHEMBL1909146
(2)
|
0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | CHEMBL94 |
CHEMBL1909104
(2)
|
0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | CHEMBL94 |
CHEMBL1909144
(2)
|
0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | CHEMBL94 |
CHEMBL1909100
(2)
|
0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | CHEMBL94 |
CHEMBL1909167
(2)
|
1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | CHEMBL94 |
CHEMBL1909129
(2)
|
0 / 0 |
| P08311 | Cathepsin G | S1A | CHEMBL94 |
CHEMBL1909194
(2)
|
0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | CHEMBL94 |
CHEMBL1909110
(2)
|
1 / 0 |
| O00519 | Fatty-acid amide hydrolase 1 | Enzyme | CHEMBL94 |
CHEMBL1099470
(2)
|
0 / 0 |
| P03956 | Interstitial collagenase | M10A | CHEMBL94 |
CHEMBL1909196
(2)
|
0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | CHEMBL94 |
CHEMBL1909119
(2)
|
0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | CHEMBL1243269 |
CHEMBL1794467
(1)
|
0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | CHEMBL94 |
CHEMBL1909150
(2)
|
0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | CHEMBL94 |
CHEMBL747118
(1)
CHEMBL747438
(1)
CHEMBL917212 (1) CHEMBL1909171 (2) |
2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | CHEMBL94 |
CHEMBL747396
(1)
CHEMBL1909170
(2)
|
0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | CHEMBL94 |
CHEMBL1909122
(2)
|
0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | CHEMBL94 |
CHEMBL1909109
(2)
|
2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | CHEMBL94 |
CHEMBL1909205
(2)
|
5 / 10 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | CHEMBL94 |
CHEMBL1909172
(2)
|
1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | CHEMBL94 |
CHEMBL1909114
(2)
|
0 / 0 |
| P06276 | Cholinesterase | Hydrolase | CHEMBL94 CHEMBL76640 CHEMBL382351 |
CHEMBL875256
(1)
CHEMBL653527
(1)
CHEMBL651303 (2) CHEMBL651305 (1) CHEMBL654401 (1) CHEMBL876073 (2) CHEMBL654408 (1) CHEMBL654416 (1) CHEMBL656094 (1) CHEMBL857083 (1) CHEMBL655895 (1) CHEMBL655896 (1) CHEMBL654880 (1) CHEMBL654881 (1) CHEMBL654886 (2) CHEMBL884137 (2) CHEMBL856086 (1) CHEMBL659263 (1) CHEMBL844948 (1) CHEMBL849719 (1) CHEMBL848218 (1) CHEMBL847600 (1) CHEMBL851337 (1) CHEMBL832431 (1) CHEMBL829512 (1) CHEMBL874576 (1) CHEMBL861175 (2) CHEMBL859944 (2) CHEMBL911303 (2) CHEMBL917210 (1) CHEMBL917211 (1) CHEMBL985794 (1) CHEMBL986292 (1) CHEMBL1040051 (1) CHEMBL1042758 (1) CHEMBL1176720 (1) |
0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | CHEMBL94 |
CHEMBL1909125
(2)
|
0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | CHEMBL94 |
CHEMBL1909126
(2)
|
3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | CHEMBL94 |
CHEMBL1909108
(2)
|
0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | CHEMBL94 |
CHEMBL1909124
(2)
|
1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | CHEMBL94 |
CHEMBL1909200
(2)
|
0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | CHEMBL94 |
CHEMBL1909207
(2)
|
2 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL94 CHEMBL1243269 |
CHEMBL1741322
(3)
CHEMBL1909132
(2)
|
0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | CHEMBL94 |
CHEMBL1909186
(2)
|
0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | CHEMBL94 |
CHEMBL1909145
(2)
|
1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | CHEMBL94 |
CHEMBL1909091
(2)
|
1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | CHEMBL94 CHEMBL306319 CHEMBL76640 CHEMBL382351 CHEMBL1243269 |
CHEMBL644926
(1)
CHEMBL644099
(2)
CHEMBL644104 (1) CHEMBL644105 (1) CHEMBL644107 (1) CHEMBL885303 (1) CHEMBL644830 (1) CHEMBL644833 (1) CHEMBL644838 (1) CHEMBL645001 (1) CHEMBL645002 (1) CHEMBL875789 (1) CHEMBL642295 (1) CHEMBL644626 (2) CHEMBL644628 (1) CHEMBL644788 (2) CHEMBL644789 (2) CHEMBL644790 (1) CHEMBL641511 (1) CHEMBL641020 (1) CHEMBL875256 (1) CHEMBL643069 (1) CHEMBL638446 (1) CHEMBL638449 (1) CHEMBL638603 (1) CHEMBL643381 (1) CHEMBL641238 (1) CHEMBL654881 (1) CHEMBL844948 (1) CHEMBL849719 (1) CHEMBL848218 (1) CHEMBL847600 (1) CHEMBL851337 (1) CHEMBL829249 (2) CHEMBL832454 (1) CHEMBL874440 (1) CHEMBL874576 (1) CHEMBL827539 (1) CHEMBL859798 (2) CHEMBL859944 (2) CHEMBL911302 (2) CHEMBL917209 (1) CHEMBL917211 (1) CHEMBL917213 (1) CHEMBL914532 (1) CHEMBL914533 (1) CHEMBL1031199 (1) CHEMBL1033653 (1) CHEMBL1176719 (1) CHEMBL1249049 (5) CHEMBL1909212 (2) CHEMBL2014392 (1) CHEMBL2014393 (1) |
1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | CHEMBL94 |
CHEMBL1909211
(2)
|
0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | CHEMBL94 |
CHEMBL1909105
(2)
|
0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | CHEMBL94 |
CHEMBL1909182
(2)
|
0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | CHEMBL94 |
CHEMBL1909173
(2)
|
0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | CHEMBL94 |
CHEMBL1909113
(2)
|
0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | CHEMBL94 |
CHEMBL1909187
(2)
|
0 / 0 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | CHEMBL94 |
CHEMBL1909168
(2)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL94 CHEMBL1243269 |
CHEMBL1741323
(3)
CHEMBL1909134
(2)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL94 CHEMBL1243269 |
CHEMBL1741324
(3)
CHEMBL1909138
(2)
|
0 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | CHEMBL94 |
CHEMBL1909137
(2)
|
0 / 0 |
| Q99549 | M-phase phosphoprotein 8 | Unclassified protein | CHEMBL94 |
CHEMBL1738402
(1)
|
0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL94 |
CHEMBL2114890
(1)
|
0 / 0 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | CHEMBL94 |
CHEMBL1909094
(2)
|
1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | CHEMBL94 |
CHEMBL1909087
(2)
|
0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | CHEMBL94 |
CHEMBL1909213
(2)
|
0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | CHEMBL94 |
CHEMBL1909089
(2)
|
0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | CHEMBL94 |
CHEMBL1909116
(2)
|
1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | CHEMBL94 |
CHEMBL1909206
(2)
|
0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | CHEMBL94 |
CHEMBL1909128
(2)
|
0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | CHEMBL94 CHEMBL11773 CHEMBL76640 CHEMBL1243269 |
CHEMBL1613914
(4)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL94 |
CHEMBL1738442
(2)
|
0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | CHEMBL94 |
CHEMBL2354311
(1)
|
1 / 0 |
| O00255 | Menin | Unclassified protein | CHEMBL1243269 |
CHEMBL1614531
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL1243269 |
CHEMBL1614531
(1)
|
1 / 3 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | CHEMBL94 |
CHEMBL2114738
(2)
|
0 / 0 |
CTD interaction (18)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D010830 | 13 |
AADAC
CES5A1 DAC |
arylacetamide deacetylase (EC:3.1.1.3) | Physostigmine inhibits the reaction [AADAC protein results in decreased acetylation of Rifabutin] |
decreases acetylation
/ decreases reaction |
protein |
21856291
|
| D010830 | 13 |
AADAC
CES5A1 DAC |
arylacetamide deacetylase (EC:3.1.1.3) | Physostigmine inhibits the reaction [AADAC protein results in decreased acetylation of Rifampin] |
decreases acetylation
/ decreases reaction |
protein |
21856291
|
| D010830 | 13 |
AADAC
CES5A1 DAC |
arylacetamide deacetylase (EC:3.1.1.3) | Physostigmine inhibits the reaction [AADAC protein results in decreased acetylation of rifapentine] |
decreases acetylation
/ decreases reaction |
protein |
21856291
|
| D010830 | 43 |
ACHE
ACEE ARACHE N-ACHE YT |
acetylcholinesterase (EC:3.1.1.7) | [Physostigmine co-treated with Dichlorvos] results in decreased activity of ACHE protein |
affects cotreatment
/ decreases activity |
protein |
4859365
|
| D010830 | 43 |
ACHE
ACEE ARACHE N-ACHE YT |
acetylcholinesterase (EC:3.1.1.7) | Physostigmine inhibits the reaction [Soman results in decreased activity of ACHE protein] |
decreases activity
/ decreases reaction |
protein |
21402092
21414391 |
| D010830 | 43 |
ACHE
ACEE ARACHE N-ACHE YT |
acetylcholinesterase (EC:3.1.1.7) | [Physostigmine inhibits the reaction [Soman results in decreased activity of ACHE protein]] which results in decreased carbamoylation of ACHE protein |
decreases activity
/ decreases carbamoylation / decreases reaction |
protein |
21402092
|
| D010830 | 43 |
ACHE
ACEE ARACHE N-ACHE YT |
acetylcholinesterase (EC:3.1.1.7) | Physostigmine results in decreased activity of ACHE protein |
decreases activity
|
protein |
4859365
21414391 |
| D010830 | 8824 |
CES2
CE-2 CES2A1 PCE-2 iCE |
carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56) | Physostigmine results in decreased activity of CES2 protein |
decreases activity
|
protein |
9169443
|
| D010830 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | Physostigmine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] |
affects binding
/ decreases activity |
protein |
14645658
|
| D010830 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | Physostigmine binds to [CHRNA4 protein binds to CHRNB2 protein] |
affects binding
|
protein |
15733544
|
| D010830 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | Physostigmine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| D010830 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | Physostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] |
affects activity
/ affects binding / increases reaction |
protein |
15733544
|
| D010830 | 1137 |
CHRNA4
BFNC EBN EBN1 NACHR NACHRA4 NACRA4 |
cholinergic receptor, nicotinic, alpha 4 (neuronal) | Physostigmine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] |
affects binding
/ decreases activity |
protein |
14645658
|
| D010830 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | Physostigmine binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] |
affects binding
/ decreases activity |
protein |
14645658
|
| D010830 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | Physostigmine binds to [CHRNA4 protein binds to CHRNB2 protein] |
affects binding
|
protein |
15733544
|
| D010830 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | Physostigmine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] |
affects binding
/ decreases reaction |
protein |
14645658
|
| D010830 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | Physostigmine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] |
affects activity
/ affects binding / increases reaction |
protein |
15733544
|
| D010830 | 1141 |
CHRNB2
EFNL3 nAChRB2 |
cholinergic receptor, nicotinic, beta 2 (neuronal) | Physostigmine results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] |
affects binding
/ decreases activity |
protein |
14645658
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (58)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 |
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #278000 | Lysosomal acid lipase deficiency |
P38571
|
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #159900 | Myoclonic dystonia |
P14416
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (52)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00148 | Lysosomal acid lipase deficiency |
P38571
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
Q16637 (related) |
Diseases related to CTD interactions
83 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D000544 | D010830 | Alzheimer Disease |
therapeutic
|
3717434
4003595 |
|
| D000647 | D010830 | Amnesia |
marker/mechanism
therapeutic |
106402
1763119 7926587 8119309 9268086 9799963 16174677 |
|
| D001049 | D010830 | Apnea |
therapeutic
|
1742831
6196992 6940962 7032671 7270862 |
|
| D001145 | D010830 | Arrhythmias, Cardiac |
marker/mechanism
therapeutic |
4044537
6269268 |
|
| D001264 | D010830 | Athetosis |
therapeutic
|
8123277
|
|
| D001281 | D010830 | Atrial Fibrillation |
marker/mechanism
|
6871781
17453877 |
|
| D054537 | D010830 | Atrioventricular Block |
marker/mechanism
|
7001962
|
|
| D001919 | D010830 | Bradycardia |
marker/mechanism
|
6148684
7001962 7018912 11740913 15741579 17453877 |
|
| D002545 | D010830 | Brain Ischemia |
marker/mechanism
|
8102038
|
|
| D002375 | D010830 | Catalepsy |
marker/mechanism
therapeutic |
40649
119254 1033567 3362916 6540616 6891961 9264077 10893700 |
|
| D002385 | D010830 | Cataplexy |
marker/mechanism
|
8008205
|
|
| D002493 | D010830 | Central Nervous System Diseases |
therapeutic
|
16905092
|
|
| D023341 | D010830 | Chills |
therapeutic
|
8202114
|
|
| D002819 | D010830 | Chorea |
therapeutic
|
4358998
|
|
| D019970 | D010830 | Cocaine-Related Disorders |
therapeutic
|
20393457
|
|
| D003072 | D010830 | Cognition Disorders |
marker/mechanism
therapeutic |
11337201
14729117 |
|
| D003128 | D010830 | COMA |
therapeutic
|
559431
6614520 |
|
| D003221 | D010830 | Confusion |
therapeutic
|
762851
1267895 |
|
| D003244 | D010830 | Consciousness Disorders |
therapeutic
|
242240
|
|
| D055191 | D010830 | Delayed Emergence from Anesthesia |
therapeutic
|
16905092
|
|
| D003693 | D010830 | Delirium |
therapeutic
|
54535
241267 559431 2927404 3605428 4189068 4424019 5102638 6026788 6833524 7340135 8202114 12827117 15038335 16749552 20930599 |
|
| D003866 | D010830 | Depressive Disorder |
marker/mechanism
|
7012883
|
|
| D006970 | D010830 | Disorders of Excessive Somnolence |
therapeutic
|
1267895
14999367 |
|
| D062787 | D010830 | Drug Overdose |
therapeutic
|
6269268
6614520 7001962 11529713 12369036 |
|
| D064420 | D010830 | Drug-Related Side Effects and Adverse Reactions |
marker/mechanism
therapeutic |
4189068
4405503 10713877 15741579 |
|
| D004409 | D010830 | Dyskinesia, Drug-Induced |
therapeutic
|
4358998
8106150 |
|
| D004421 | D010830 | Dystonia |
therapeutic
|
1742831
|
|
| D020821 | D010830 | Dystonic Disorders |
therapeutic
|
8123277
|
|
| D004831 | D010830 | Epilepsies, Myoclonic |
marker/mechanism
|
1620139
|
|
| D005207 | D010830 | Fasciculation |
marker/mechanism
|
15741579
|
|
| D005334 | D010830 | Fever |
therapeutic
|
8202114
|
|
| D015812 | D010830 | Glaucoma, Angle-Closure |
therapeutic
|
5013835
|
|
| D006212 | D010830 | Hallucinations |
therapeutic
|
7497894
|
|
| D006323 | D010830 | Heart Arrest |
marker/mechanism
|
7001962
15741579 |
|
| D006816 | D010830 | Huntington Disease |
therapeutic
|
4358998
|
|
| D006948 | D010830 | Hyperkinesis |
therapeutic
|
137340
2173542 2243341 3202815 7857593 |
|
| D006973 | D010830 | Hypertension |
marker/mechanism
therapeutic |
3443423
3717434 3996883 4003595 4913676 6095780 9112085 |
|
| D007008 | D010830 | Hypokalemia |
therapeutic
|
7497894
|
|
| D007022 | D010830 | Hypotension |
marker/mechanism
therapeutic |
7001962
8010419 17453877 |
|
| D007024 | D010830 | Hypotension, Orthostatic |
therapeutic
|
1665057
|
|
| D007035 | D010830 | Hypothermia |
marker/mechanism
therapeutic |
5040657
6621715 7617694 8119309 |
|
| D007247 | D010830 | Infertility, Female |
marker/mechanism
|
30586
|
|
| D007859 | D010830 | Learning Disorders |
therapeutic
|
19616041
20298728 |
|
| D053609 | D010830 | Lethargy |
therapeutic
|
762851
|
|
| D008325 | D010830 | Mammary Neoplasms, Experimental |
marker/mechanism
|
11401758
|
|
| D008569 | D010830 | Memory Disorders |
therapeutic
|
2083362
9040502 |
|
| D001523 | D010830 | Mental Disorders |
therapeutic
|
11109424
|
|
| D015877 | D010830 | Miosis |
marker/mechanism
|
8119309
|
|
| D019964 | D010830 | Mood Disorders |
marker/mechanism
|
40018
|
|
| D009069 | D010830 | Movement Disorders |
therapeutic
|
20072119
|
|
| D015878 | D010830 | Mydriasis |
marker/mechanism
therapeutic |
6892185
16104118 |
|
| D009207 | D010830 | Myoclonus |
marker/mechanism
therapeutic |
1620139
3808321 6890654 15038335 |
|
| D009325 | D010830 | Nausea |
marker/mechanism
|
40018
3354874 |
|
| D009461 | D010830 | Neurologic Manifestations |
therapeutic
|
11109424
|
|
| D009759 | D010830 | Nystagmus, Pathologic |
therapeutic
|
3877148
|
|
| D009886 | D010830 | Ophthalmoplegia |
therapeutic
|
6890654
11975095 |
|
| D010146 | D010830 | Pain |
therapeutic
|
19260335
|
|
| D010554 | D010830 | Personality Disorders |
therapeutic
|
145765
573894 |
|
| D010939 | D010830 | Plant Poisoning |
therapeutic
|
11109424
|
|
| D011041 | D010830 | Poisoning |
marker/mechanism
|
17157343
|
|
| D011183 | D010830 | Postoperative Complications |
therapeutic
|
1267895
5102638 7091735 |
|
| D020250 | D010830 | Postoperative Nausea and Vomiting |
marker/mechanism
|
17655781
|
|
| D011595 | D010830 | Psychomotor Agitation |
therapeutic
|
242240
6833524 |
|
| D011596 | D010830 | Psychomotor Disorders |
marker/mechanism
|
40018
|
|
| D011605 | D010830 | Psychoses, Substance-Induced |
therapeutic
|
1115577
4027811 7497894 |
|
| D012131 | D010830 | Respiratory Insufficiency |
therapeutic
|
7085965
14999367 |
|
| D012640 | D010830 | Seizures |
marker/mechanism
therapeutic |
1173100
6215091 6269268 6301005 6421394 6446956 6892185 8224101 11824763 15741579 17157343 22310180 |
|
| D012798 | D010830 | Sialorrhea |
marker/mechanism
|
8119309
|
|
| D020181 | D010830 | Sleep Apnea, Obstructive |
therapeutic
|
12958052
|
|
| D013064 | D010830 | Speech Disorders |
therapeutic
|
7497894
|
|
| D013132 | D010830 | Spinocerebellar Degenerations |
therapeutic
|
3877148
|
|
| D013226 | D010830 | Status Epilepticus |
marker/mechanism
therapeutic |
2824229
7001962 |
|
| D053608 | D010830 | Stupor |
marker/mechanism
therapeutic |
108720
470064 8202114 |
|
| D013375 | D010830 | Substance Withdrawal Syndrome |
therapeutic
|
8829152
|
|
| D013610 | D010830 | Tachycardia |
marker/mechanism
therapeutic |
54535
3354874 3996883 4003595 11740913 |
|
| D013616 | D010830 | Tachycardia, Sinus |
therapeutic
|
7497894
|
|
| D017180 | D010830 | Tachycardia, Ventricular |
therapeutic
|
1787292
|
|
| D016171 | D010830 | Torsades de Pointes |
therapeutic
|
11529713
|
|
| D014202 | D010830 | Tremor |
marker/mechanism
therapeutic |
2576144
2984330 3202815 3362916 4048228 4651776 6258692 6621715 6791238 6892185 7639639 8119309 8205054 10762688 |
|
| D014474 | D010830 | Unconsciousness |
therapeutic
|
7270862
|
|
| D014693 | D010830 | Ventricular Fibrillation |
therapeutic
|
5040657
|
|
| D014839 | D010830 | Vomiting |
marker/mechanism
|
40018
3354874 |
|
| D014987 | D010830 | Xerostomia |
therapeutic
|
16104118
|