KNApSAcK Metabolite C00017671
Metabolite
KNApSAcK Entry
| id | C00017671 |
|---|---|
| Name | UCN 02 / 7-epi-Hydroxystaurosporine |
| CAS RN | 121569-61-7 |
| Standard InChI | InChI=1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27+,28+/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 251 |
Link
ChEMBL
| By standard InChI | CHEMBL574737 |
|---|---|
| By standard InChI Main Layer | CHEMBL339799 CHEMBL338049 CHEMBL574737 CHEMBL601799 CHEMBL1236539 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Streptomycetaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Streptomyces sp. N-126 | 1883 | Streptomycetaceae | Bacteria |
Human Protein / Gene in interaction
81 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| Q02750 | Dual specificity mitogen-activated protein kinase kinase 1 | Ste7 | CHEMBL574737 |
CHEMBL1060205
(1)
|
1 / 1 |
| Q9P1W9 | Serine/threonine-protein kinase pim-2 | Pim | CHEMBL574737 |
CHEMBL1051298
(1)
|
0 / 0 |
| Q8TDX7 | Serine/threonine-protein kinase Nek7 | Nek | CHEMBL574737 |
CHEMBL1060150
(1)
|
0 / 0 |
| Q15759 | Mitogen-activated protein kinase 11 | p38 | CHEMBL574737 |
CHEMBL1062771
(1)
|
0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | CHEMBL574737 |
CHEMBL1052110
(1)
|
0 / 0 |
| O15530 | 3-phosphoinositide-dependent protein kinase 1 | Pdk1 | CHEMBL574737 |
CHEMBL1063720
(1)
|
0 / 0 |
| P41240 | Tyrosine-protein kinase CSK | Csk | CHEMBL574737 |
CHEMBL1062801
(1)
|
0 / 0 |
| P45984 | Mitogen-activated protein kinase 9 | Jnk | CHEMBL574737 |
CHEMBL1062756
(1)
|
0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | CHEMBL574737 CHEMBL339799 CHEMBL338049 |
CHEMBL767434
(2)
CHEMBL767445
(2)
CHEMBL1061088 (1) |
0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | CHEMBL574737 |
CHEMBL1061209
(1)
|
0 / 0 |
| O14757 | Serine/threonine-protein kinase Chk1 | Chk1 | CHEMBL574737 |
CHEMBL1062800
(1)
CHEMBL1228397
(1)
CHEMBL1287592 (1) |
0 / 0 |
| Q8IWQ3 | Serine/threonine-protein kinase BRSK2 | CAMK serine/threonine protein kinase BRSK subfamily | CHEMBL574737 |
CHEMBL1062893
(1)
|
0 / 0 |
| P27448 | MAP/microtubule affinity-regulating kinase 3 | CAMK serine/threonine protein kinase MARK subfamily | CHEMBL574737 |
CHEMBL1062760
(1)
|
0 / 0 |
| Q05513 | Protein kinase C zeta type | Iota | CHEMBL574737 CHEMBL339799 CHEMBL338049 |
CHEMBL767434
(2)
CHEMBL767445
(2)
CHEMBL1062856 (1) |
0 / 0 |
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | CHEMBL574737 |
CHEMBL1051297
(1)
|
0 / 0 |
| P23443 | Ribosomal protein S6 kinase beta-1 | p70 | CHEMBL574737 |
CHEMBL1061106
(1)
|
0 / 0 |
| Q9UQB9 | Aurora kinase C | Aur | CHEMBL574737 |
CHEMBL1061992
(1)
|
1 / 1 |
| Q9HBH9 | MAP kinase-interacting serine/threonine-protein kinase 2 | CAMK serine/threonine protein kinase MNK subfamily | CHEMBL574737 |
CHEMBL1062764
(1)
|
0 / 0 |
| Q9NQU5 | Serine/threonine-protein kinase PAK 6 | STE serine/threonine protein kinase PAKB subfamily | CHEMBL574737 |
CHEMBL1051294
(1)
|
0 / 0 |
| Q16644 | MAP kinase-activated protein kinase 3 | CAMK serine/threonine protein kinase MAPKAPK | CHEMBL574737 |
CHEMBL1063755
(1)
|
0 / 0 |
| Q9H422 | Homeodomain-interacting protein kinase 3 | CMGC dual-specificity kinase HIPK | CHEMBL574737 |
CHEMBL1061963
(1)
|
0 / 0 |
| Q14680 | Maternal embryonic leucine zipper kinase | Melk | CHEMBL574737 |
CHEMBL1060204
(1)
|
0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | CHEMBL338049 |
CHEMBL677890
(1)
|
1 / 11 |
| Q15746 | Myosin light chain kinase, smooth muscle | Mlck | CHEMBL574737 |
CHEMBL1052120
(1)
|
1 / 1 |
| Q13188 | Serine/threonine-protein kinase 3 | STE serine/threonine protein kinase MST subfamily | CHEMBL574737 |
CHEMBL1060208
(1)
|
0 / 0 |
| P31751 | RAC-beta serine/threonine-protein kinase | Akt | CHEMBL574737 |
CHEMBL1061915
(1)
|
2 / 2 |
| O75582 | Ribosomal protein S6 kinase alpha-5 | CAMK serine/threonine protein kinase MSKB subfamily | CHEMBL574737 |
CHEMBL1062766
(1)
|
0 / 0 |
| O14920 | Inhibitor of nuclear factor kappa-B kinase subunit beta | Other serine/threonine protein kinase | CHEMBL574737 |
CHEMBL1063750
(1)
|
0 / 0 |
| Q16513 | Serine/threonine-protein kinase N2 | Pkn | CHEMBL574737 |
CHEMBL1063770
(1)
|
0 / 0 |
| Q15139 | Serine/threonine-protein kinase D1 | Pkd | CHEMBL574737 CHEMBL339799 CHEMBL338049 |
CHEMBL767434
(2)
CHEMBL767445
(2)
CHEMBL1062020 (1) |
0 / 0 |
| Q8N5S9 | Calcium/calmodulin-dependent protein kinase kinase 1 | META serine/threonine protein kinase subfamily | CHEMBL574737 |
CHEMBL1052070
(1)
|
0 / 0 |
| Q9P286 | Serine/threonine-protein kinase PAK 7 | STE serine/threonine protein kinase PAKB subfamily | CHEMBL574737 |
CHEMBL1051292
(1)
|
0 / 0 |
| Q96SB4 | SRSF protein kinase 1 | Srpk | CHEMBL574737 |
CHEMBL1052122
(1)
|
0 / 0 |
| Q92630 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 | CMGC dual-specificity kinase DYRK2 | CHEMBL574737 |
CHEMBL1052073
(1)
|
0 / 0 |
| O43781 | Dual specificity tyrosine-phosphorylation-regulated kinase 3 | CMGC dual-specificity kinase DYRK2 | CHEMBL574737 |
CHEMBL1062804
(1)
|
0 / 0 |
| O96013 | Serine/threonine-protein kinase PAK 4 | STE serine/threonine protein kinase PAKB subfamily | CHEMBL574737 |
CHEMBL1063662
(1)
|
0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | CHEMBL574737 |
CHEMBL1062808
(1)
|
0 / 0 |
| Q15418 | Ribosomal protein S6 kinase alpha-1 | Rskb | CHEMBL574737 |
CHEMBL1063776
(1)
|
0 / 0 |
| O15264 | Mitogen-activated protein kinase 13 | p38 | CHEMBL574737 |
CHEMBL1060130
(1)
|
0 / 0 |
| P53779 | Mitogen-activated protein kinase 10 | Jnk | CHEMBL574737 |
CHEMBL1062816
(1)
|
0 / 1 |
| P51955 | Serine/threonine-protein kinase Nek2 | Nek | CHEMBL574737 |
CHEMBL1063762
(1)
|
0 / 0 |
| Q96RR4 | Calcium/calmodulin-dependent protein kinase kinase 2 | META serine/threonine protein kinase subfamily | CHEMBL574737 |
CHEMBL1051372
(1)
|
0 / 0 |
| Q9BUB5 | MAP kinase-interacting serine/threonine-protein kinase 1 | CAMK serine/threonine protein kinase MNK subfamily | CHEMBL574737 |
CHEMBL1063758
(1)
|
0 / 0 |
| P48730 | Casein kinase I isoform delta | Ck1 | CHEMBL574737 |
CHEMBL1052083
(1)
|
1 / 0 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | CHEMBL338049 |
CHEMBL806345
(1)
|
0 / 0 |
| Q96GD4 | Aurora kinase B | Aur | CHEMBL574737 |
CHEMBL1051271
(1)
|
0 / 0 |
| P49137 | MAP kinase-activated protein kinase 2 | CAMK serine/threonine protein kinase MAPKAPK | CHEMBL574737 |
CHEMBL1060125
(1)
|
0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | CHEMBL574737 |
CHEMBL1062010
(1)
|
0 / 0 |
| P45983 | Mitogen-activated protein kinase 8 | Jnk | CHEMBL574737 |
CHEMBL1061967
(1)
|
0 / 0 |
| P53350 | Serine/threonine-protein kinase PLK1 | PLK serine/threonine protein kinase subfamily | CHEMBL574737 |
CHEMBL1060216
(1)
|
0 / 0 |
| Q8IW41 | MAP kinase-activated protein kinase 5 | CAMK serine/threonine protein kinase MAPKAPK | CHEMBL574737 |
CHEMBL1061100
(1)
|
0 / 0 |
| O75116 | Rho-associated protein kinase 2 | Rock | CHEMBL574737 |
CHEMBL1063773
(1)
|
0 / 0 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | CHEMBL574737 |
CHEMBL1061913
(1)
|
4 / 1 |
| O00141 | Serine/threonine-protein kinase Sgk1 | AGC serine/threonine protein kinase SGK subfamily | CHEMBL574737 |
CHEMBL1060220
(1)
|
0 / 0 |
| P51812 | Ribosomal protein S6 kinase alpha-3 | Rskb | CHEMBL574737 |
CHEMBL1063682
(1)
|
2 / 2 |
| Q9HC98 | Serine/threonine-protein kinase Nek6 | Nek | CHEMBL574737 |
CHEMBL1060127
(1)
|
0 / 0 |
| Q9H2X6 | Homeodomain-interacting protein kinase 2 | CMGC dual-specificity kinase HIPK | CHEMBL574737 |
CHEMBL1052094
(1)
|
0 / 0 |
| O96017 | Serine/threonine-protein kinase Chk2 | Rad53 | CHEMBL574737 |
CHEMBL1062899
(1)
CHEMBL1228398
(1)
|
4 / 1 |
| Q14012 | Calcium/calmodulin-dependent protein kinase type 1 | Camk1 | CHEMBL574737 |
CHEMBL1062894
(1)
|
0 / 0 |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | Pka | CHEMBL574737 CHEMBL339799 CHEMBL338049 |
CHEMBL772605
(2)
CHEMBL768001
(2)
CHEMBL1061087 (1) |
0 / 0 |
| Q13627 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | CMGC dual-specificity kinase DYRK1 | CHEMBL574737 |
CHEMBL1052085
(1)
|
1 / 0 |
| P53778 | Mitogen-activated protein kinase 12 | p38 | CHEMBL574737 |
CHEMBL1052113
(1)
|
0 / 0 |
| O00418 | Eukaryotic elongation factor 2 kinase | Atypical serine/threonine protein kinase alpha subfamily | CHEMBL574737 |
CHEMBL1052074
(1)
|
0 / 0 |
| Q8TD08 | Mitogen-activated protein kinase 15 | Mapk | CHEMBL574737 |
CHEMBL1061212
(1)
|
0 / 0 |
| Q86V86 | Serine/threonine-protein kinase pim-3 | Pim | CHEMBL574737 |
CHEMBL1061911
(1)
|
0 / 0 |
| Q04759 | Protein kinase C theta type | Delta | CHEMBL339799 CHEMBL338049 CHEMBL574737 |
CHEMBL767434
(2)
CHEMBL767445
(2)
|
0 / 1 |
| Q02156 | Protein kinase C epsilon type | Eta | CHEMBL339799 CHEMBL338049 CHEMBL574737 |
CHEMBL767434
(2)
CHEMBL767445
(2)
|
0 / 0 |
| O94806 | Serine/threonine-protein kinase D3 | Pkd | CHEMBL339799 CHEMBL338049 CHEMBL574737 |
CHEMBL767434
(2)
CHEMBL767445
(2)
|
0 / 0 |
| Q05655 | Protein kinase C delta type | Delta | CHEMBL339799 CHEMBL338049 CHEMBL574737 |
CHEMBL767434
(2)
CHEMBL767445
(2)
|
0 / 0 |
| P05129 | Protein kinase C gamma type | Alpha | CHEMBL339799 CHEMBL338049 CHEMBL574737 |
CHEMBL767434
(2)
CHEMBL767445
(2)
|
1 / 1 |
| P05771 | Protein kinase C beta type | Alpha | CHEMBL339799 CHEMBL338049 CHEMBL574737 |
CHEMBL767434
(2)
CHEMBL767445
(2)
|
0 / 0 |
| P24723 | Protein kinase C eta type | Eta | CHEMBL339799 CHEMBL338049 CHEMBL574737 |
CHEMBL767434
(2)
CHEMBL767445
(2)
|
1 / 0 |
| P41743 | Protein kinase C iota type | Iota | CHEMBL339799 CHEMBL338049 CHEMBL574737 |
CHEMBL767434
(2)
CHEMBL767445
(2)
|
0 / 0 |
| P20248 | Cyclin-A2 | Other cytosolic protein | CHEMBL574737 |
CHEMBL1052071
(1)
|
0 / 0 |
| P78396 | Cyclin-A1 | Other cytosolic protein | CHEMBL574737 |
CHEMBL1052071
(1)
|
0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | CHEMBL574737 |
CHEMBL1052071
(1)
|
0 / 0 |
| P22694 | cAMP-dependent protein kinase catalytic subunit beta | Pka | CHEMBL339799 CHEMBL338049 CHEMBL574737 |
CHEMBL772605
(2)
CHEMBL768001
(2)
|
0 / 0 |
| P22612 | cAMP-dependent protein kinase catalytic subunit gamma | Pka | CHEMBL339799 CHEMBL338049 CHEMBL574737 |
CHEMBL772605
(2)
CHEMBL768001
(2)
|
0 / 0 |
| P68400 | Casein kinase II subunit alpha | Ck2 | CHEMBL574737 |
CHEMBL1061204
(1)
|
0 / 0 |
| P19784 | Casein kinase II subunit alpha' | Ck2 | CHEMBL574737 |
CHEMBL1061204
(1)
|
0 / 0 |
| P67870 | Casein kinase II subunit beta | REG serine/threonine protein kinase family | CHEMBL574737 |
CHEMBL1061204
(1)
|
0 / 0 |
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (19)
| OMIM | preferred title | UniProt |
|---|---|---|
| #615224 | Advanced sleep phase syndrome, familial, 2; fasps2 |
P48730
|
| #613780 | Aortic aneurysm, familial thoracic 7; aat7 |
Q15746
|
| #114480 | Breast cancer |
O96017
P31749 |
| #615279 | Cardiofaciocutaneous syndrome 3; cfc3 |
Q02750
|
| #303600 | Coffin-lowry syndrome; cls |
P51812
|
| #114500 | Colorectal cancer; crc |
P31749
|
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P31751
|
| #240900 | Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh |
P31751
|
| #609265 | Li-fraumeni syndrome 2; lfs2 |
O96017
|
| #211980 | Lung cancer |
P00533
|
| #614104 | Mental retardation, autosomal dominant 7; mrd7 |
Q13627
|
| #300844 | Mental retardation, x-linked 19; mrx19 |
P51812
|
| #259500 | Osteogenic sarcoma |
O96017
|
| #176807 | Prostate cancer |
O96017
|
| #176920 | Proteus syndrome |
P31749
|
| #243060 | Spermatogenic failure 5; spgf5 |
Q9UQB9
|
| #605361 | Spinocerebellar ataxia 14; sca14 |
P05129
|
| #601367 | Stroke, ischemic |
P24723
|
KEGG DISEASE (20)
| KEGG | disease name | UniProt |
|---|---|---|
| H00881 | Li-Fraumeni syndrome |
O96017
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
|
| H00018 | Gastric cancer |
P00533
(related)
|
| H00022 | Bladder cancer |
P00533
(related)
|
| H00028 | Choriocarcinoma |
P00533
(related)
|
| H00030 | Cervical cancer |
P00533
(related)
|
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00063 | Spinocerebellar ataxia (SCA) |
P05129
(related)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H00027 | Ovarian cancer |
P31751
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P31751
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P51812
(related)
|
| H00574 | Coffin-Lowry syndrome (CLS) |
P51812
(related)
|
| H00606 | Early infantile epileptic encephalopathy |
P53779
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q02750
(related)
|
| H00408 | Type I diabetes mellitus |
Q04759
(related)
|
| H00801 | Familial thoracic aortic aneurysm and dissection (TAAD) |
Q15746
(related)
|
| H01282 | Spermatogenic failure |
Q9UQB9
(related)
|