PCIDB

KNApSAcK Metabolite C00017865

Metabolite

KNApSAcK Entry

id C00017865
Name NSC 359079 / Rebeccamycin
CAS RN 93908-02-2
Standard InChI InChI=1S/C27H21Cl2N3O7/c1-38-24-13(8-33)39-27(23(35)22(24)34)32-20-10(5-3-7-12(20)29)15-17-16(25(36)31-26(17)37)14-9-4-2-6-11(28)18(9)30-19(14)21(15)32/h2-7,13,22-24,27,30,33-35H,8H2,1H3,(H,31,36,37)/t13?,22-,23?,24-,27-/m1/s1
Standard InChI (Main Layer) InChI=1S/C27H21Cl2N3O7/c1-38-24-13(8-33)39-27(23(35)22(24)34)32-20-10(5-3-7-12(20)29)15-17-16(25(36)31-26(17)37)14-9-4-2-6-11(28)18(9)30-19(14)21(15)32/h2-7,13,22-24,27,30,33-35H,8H2,1H3,(H,31,36,37)

Cluster

Phytochemical cluster
KCF-S cluster No. 2063

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL27000 CHEMBL370100

KEGG

By LinkDB C19701

CTD

By CAS RN C053339

Species

Summary

Plant class

class name count

Family

family name count
Nocardiaceae 1

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Lechevalieria aerocolonigenes C-38,383
Nocardia aerocolonigens C-38383-RK-2 1817 Nocardiaceae Bacteria

Human Protein / Gene in interaction

31 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q99700 Ataxin-2 Unclassified protein CHEMBL27000 CHEMBL2114784 (1)
1 / 1
P17252 Protein kinase C alpha type Alpha CHEMBL370100 CHEMBL763599 (1) CHEMBL769346 (1)
CHEMBL767439 (1) CHEMBL767445 (1)
0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL27000 CHEMBL1794585 (1)
0 / 0
P11387 DNA topoisomerase 1 Isomerase CHEMBL370100 CHEMBL857616 (1) CHEMBL657247 (1)
CHEMBL856997 (1) CHEMBL815517 (1)
CHEMBL821432 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL27000 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL27000 CHEMBL2114780 (1)
0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL27000 CHEMBL2114931 (1)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL27000 CHEMBL2114810 (1)
7 / 3
Q9Y253 DNA polymerase eta Enzyme CHEMBL27000 CHEMBL1794569 (1)
1 / 1
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme CHEMBL27000 CHEMBL1963863 (1)
0 / 0
Q99816 Tumor susceptibility gene 101 protein Unclassified protein CHEMBL27000 CHEMBL1738574 (1)
0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase CHEMBL370100 CHEMBL667221 (1) CHEMBL813452 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL27000 CHEMBL1738184 (1)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL27000 CHEMBL2354311 (1)
1 / 0
Q8IUX4 DNA dC->dU-editing enzyme APOBEC-3F Enzyme CHEMBL27000 CHEMBL1963966 (1)
0 / 0
Q05513 Protein kinase C zeta type Iota CHEMBL370100 CHEMBL767439 (1) CHEMBL767445 (1)
0 / 0
Q04759 Protein kinase C theta type Delta CHEMBL370100 CHEMBL767439 (1) CHEMBL767445 (1)
0 / 1
Q02156 Protein kinase C epsilon type Eta CHEMBL370100 CHEMBL767439 (1) CHEMBL767445 (1)
0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd CHEMBL370100 CHEMBL767439 (1) CHEMBL767445 (1)
0 / 0
Q05655 Protein kinase C delta type Delta CHEMBL370100 CHEMBL767439 (1) CHEMBL767445 (1)
0 / 0
P05129 Protein kinase C gamma type Alpha CHEMBL370100 CHEMBL767439 (1) CHEMBL767445 (1)
1 / 1
P05771 Protein kinase C beta type Alpha CHEMBL370100 CHEMBL767439 (1) CHEMBL767445 (1)
0 / 0
P24723 Protein kinase C eta type Eta CHEMBL370100 CHEMBL767439 (1) CHEMBL767445 (1)
1 / 0
P41743 Protein kinase C iota type Iota CHEMBL370100 CHEMBL767439 (1) CHEMBL767445 (1)
0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd CHEMBL370100 CHEMBL767439 (1) CHEMBL767445 (1)
0 / 0
P22694 cAMP-dependent protein kinase catalytic subunit beta Pka CHEMBL370100 CHEMBL767313 (1)
0 / 0
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka CHEMBL370100 CHEMBL767313 (1)
0 / 0
P22612 cAMP-dependent protein kinase catalytic subunit gamma Pka CHEMBL370100 CHEMBL767313 (1)
0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase CHEMBL370100 CHEMBL813452 (1)
0 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein CHEMBL27000 CHEMBL2114913 (1)
0 / 3
Q06710 Paired box protein Pax-8 Unclassified protein CHEMBL27000 CHEMBL2354301 (1)
1 / 2

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (15)

OMIM preferred title UniProt
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#114500 Colorectal cancer; crc P84022
#137800 Glioma susceptibility 1; glm1 O75874
#218700 Hypothyroidism, congenital, nongoitrous, 2; chng2 Q06710
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#605361 Spinocerebellar ataxia 14; sca14 P05129
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601367 Stroke, ischemic P24723
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (10)

KEGG disease name UniProt
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
Q06710 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q99700 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00032 Thyroid cancer Q06710 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)