KNApSAcK Metabolite C00018229
Metabolite
KNApSAcK Entry
| id | C00018229 |
|---|---|
| Name | Tetrahydrobiopterin |
| CAS RN | 17528-72-2 |
| Standard InChI | InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) |
| Standard InChI (Main Layer) | InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3-4,6,12,15-16H,2H2,1H3,(H4,10,11,13,14,17) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 7555 |
Link
ChEMBL
| By standard InChI | CHEMBL337765 |
|---|---|
| By standard InChI Main Layer | CHEMBL337765 CHEMBL270788 CHEMBL1201774 CHEMBL1315516 CHEMBL1616454 |
KEGG
| By LinkDB | C00272 |
|---|
CTD
| By CAS RN | C003402 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Enterobacteriaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Escherichia coli | 562 | Enterobacteriaceae | Bacteria |
Human Protein / Gene in interaction
14 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P29475 | Nitric oxide synthase, brain | Enzyme | CHEMBL1201774 |
CHEMBL934143
(2)
|
0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL1315516 |
CHEMBL1741321
(1)
|
1 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | CHEMBL270788 |
CHEMBL1794499
(1)
|
2 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | CHEMBL1315516 |
CHEMBL1614331
(1)
|
0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL1315516 |
CHEMBL1741325
(1)
|
0 / 1 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | CHEMBL270788 |
CHEMBL1738606
(1)
|
0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | CHEMBL270788 |
CHEMBL1794467
(1)
|
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL1315516 |
CHEMBL1741322
(1)
|
0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | CHEMBL1315516 |
CHEMBL1613910
(1)
CHEMBL1614227
(1)
|
3 / 3 |
| P55210 | Caspase-7 | C14 | CHEMBL1315516 |
CHEMBL1613779
(1)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL1315516 |
CHEMBL1741323
(1)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL1315516 |
CHEMBL1741324
(1)
|
0 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL270788 |
CHEMBL1737980
(1)
|
0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL270788 |
CHEMBL1738442
(2)
|
0 / 0 |
CTD interaction (4)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| C003402 | 2643 |
GCH1
DYT14 DYT5 DYT5a GCH GTP-CH-1 GTPCH1 HPABH4B |
GTP cyclohydrolase 1 (EC:3.5.4.16) | GCH1 protein results in increased chemical synthesis of 5,6,7,8-tetrahydrobiopterin |
increases chemical synthesis
|
protein |
14551046
|
| C003402 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | 5,6,7,8-tetrahydrobiopterin deficiency inhibits the reaction [NOS3 protein results in increased abundance of Superoxides] |
decreases reaction
/ increases abundance |
protein |
19011239
|
| C003402 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | 5,6,7,8-tetrahydrobiopterin deficiency promotes the reaction [NOS3 protein results in increased abundance of Superoxides] |
increases abundance
/ increases reaction |
protein |
19011239
|
| C003402 | 6343 |
SCT
|
secretin | SCT protein results in increased abundance of 5,6,7,8-tetrahydrobiopterin |
increases abundance
|
protein |
16168596
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (7)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
KEGG DISEASE (6)
| KEGG | disease name | UniProt |
|---|---|---|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
5 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D001321 | C003402 | Autistic Disorder |
therapeutic
|
16160627
|
|
| D001927 | C003402 | Brain Diseases |
marker/mechanism
|
1389541
|
|
| D002318 | C003402 | Cardiovascular Diseases |
marker/mechanism
|
20610621
|
|
| D064420 | C003402 | Drug-Related Side Effects and Adverse Reactions |
marker/mechanism
|
1389541
|
|
| D024821 | C003402 | Metabolic Syndrome X |
therapeutic
|
17098227
|