PCIDB

KNApSAcK Metabolite C00018327

Metabolite

KNApSAcK Entry

id C00018327
Name Neplanocin A / (-)-Neplanocin A
CAS RN 72877-50-0
Standard InChI InChI=1S/C11H13N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h1,3-4,6,8-9,17-19H,2H2,(H2,12,13,14)/t6-,8-,9+/m1/s1
Standard InChI (Main Layer) InChI=1S/C11H13N5O3/c12-10-7-11(14-3-13-10)16(4-15-7)6-1-5(2-17)8(18)9(6)19/h1,3-4,6,8-9,17-19H,2H2,(H2,12,13,14)

Cluster

Phytochemical cluster
KCF-S cluster No. 1060

Link

ChEMBL

By standard InChI CHEMBL8771
By standard InChI Main Layer CHEMBL8771 CHEMBL9568 CHEMBL338953 CHEMBL128192

KEGG

By LinkDB

CTD

By CAS RN C031096

Species

Summary

Plant class

class name count

Family

family name count
Micromonosporaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Ampullariella regularis A11079 1865 Micromonosporaceae Bacteria

Human Protein / Gene in interaction

10 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P23526 Adenosylhomocysteinase Enzyme CHEMBL8771 CHEMBL664127 (1) CHEMBL804128 (1)
CHEMBL804132 (1) CHEMBL803150 (1)
CHEMBL804340 (1) CHEMBL804341 (1)
CHEMBL804342 (1) CHEMBL804343 (1)
CHEMBL804344 (1) CHEMBL804345 (1)
CHEMBL804354 (1) CHEMBL804355 (1)
CHEMBL798950 (1) CHEMBL798951 (1)
CHEMBL798953 (1) CHEMBL798958 (1)
CHEMBL798959 (1) CHEMBL798960 (1)
CHEMBL798961 (1) CHEMBL800520 (1)
CHEMBL800629 (1) CHEMBL1114610 (1)
CHEMBL1676754 (2)
1 / 1
Q99700 Ataxin-2 Unclassified protein CHEMBL9568 CHEMBL2114784 (1)
1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL9568 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL9568 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL9568 CHEMBL2114810 (1)
7 / 3
P51843 Nuclear receptor subfamily 0 group B member 1 Nuclear hormone receptor subfamily 0 group B member 1 CHEMBL9568 CHEMBL1794556 (1)
2 / 2
Q9UNA4 DNA polymerase iota Enzyme CHEMBL9568 CHEMBL1794483 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL9568 CHEMBL1738184 (1)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL9568 CHEMBL2354311 (1)
1 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein CHEMBL9568 CHEMBL2114913 (1)
0 / 3

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (14)

OMIM preferred title UniProt
#300018 46,xy sex reversal 2; srxy2 P51843
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#300200 Adrenal hypoplasia, congenital; ahc P51843
#114500 Colorectal cancer; crc P84022
#137800 Glioma susceptibility 1; glm1 O75874
#613752 Hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency P23526
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#174800 Mccune-albright syndrome; mas P63092
#166350 Osseous heteroplasia, progressive; poh P63092
#102200 Pituitary adenoma, growth hormone-secreting P63092
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (10)

KEGG disease name UniProt
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
H00184 Hypermethioninemia P23526 (related)
H00552 Glycerol kinase deficiency (GKD) P51843 (related)
H00607 46,XY disorders of sex development (Disorders of gonadal development) P51843 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)