KNApSAcK Metabolite C00019689
Metabolite
KNApSAcK Entry
| id | C00019689 |
|---|---|
| Name | Orotic acid / 6-Uracilcarboxylic acid |
| CAS RN | 65-86-1 |
| Standard InChI | InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11) |
| Standard InChI (Main Layer) | InChI=1S/C5H4N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h1H,(H,9,10)(H2,6,7,8,11) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 5438 |
Link
ChEMBL
| By standard InChI | CHEMBL1235017 |
|---|---|
| By standard InChI Main Layer | CHEMBL1235017 |
KEGG
| By LinkDB | C00295 |
|---|
CTD
| By CAS RN | D009963 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Enterobacteriaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Escherichia coli | 562 | Enterobacteriaceae | Bacteria |
Human Protein / Gene in interaction
3 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL1235017 |
CHEMBL1614544
(1)
|
11 / 10 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL1235017 |
CHEMBL1614458
(1)
|
0 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | CHEMBL1235017 |
CHEMBL1794510
(1)
|
5 / 3 |
CTD interaction (8)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D009963 | 6198 |
RPS6KB1
PS6K S6K S6K-beta-1 S6K1 STK14A p70_S6KA p70(S6K)-alpha p70-S6K p70-alpha |
ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1) | Orotic Acid inhibits the reaction [STK11 protein results in decreased phosphorylation of RPS6KB1 protein] |
decreases phosphorylation
/ decreases reaction |
protein |
22863860
|
| D009963 | 6198 |
RPS6KB1
PS6K S6K S6K-beta-1 S6K1 STK14A p70_S6KA p70(S6K)-alpha p70-S6K p70-alpha |
ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1) | Orotic Acid results in increased phosphorylation of RPS6KB1 protein |
increases phosphorylation
|
protein |
22863860
|
| D009963 | 6198 |
RPS6KB1
PS6K S6K S6K-beta-1 S6K1 STK14A p70_S6KA p70(S6K)-alpha p70-S6K p70-alpha |
ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1) | Sirolimus inhibits the reaction [Orotic Acid results in increased phosphorylation of RPS6KB1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
22863860
|
| D009963 | 57521 |
RPTOR
KOG1 Mip1 |
regulatory associated protein of MTOR, complex 1 | Orotic Acid inhibits the reaction [STK11 protein results in increased phosphorylation of RPTOR protein] |
decreases reaction
/ increases phosphorylation |
protein |
22863860
|
| D009963 | 57521 |
RPTOR
KOG1 Mip1 |
regulatory associated protein of MTOR, complex 1 | Orotic Acid results in decreased phosphorylation of RPTOR protein |
decreases phosphorylation
|
protein |
22863860
|
| D009963 | 57521 |
RPTOR
KOG1 Mip1 |
regulatory associated protein of MTOR, complex 1 | Sirolimus inhibits the reaction [Orotic Acid results in decreased phosphorylation of RPTOR protein] |
decreases phosphorylation
/ decreases reaction |
protein |
22863860
|
| D009963 | 6794 |
STK11
LKB1 PJS hLKB1 |
serine/threonine kinase 11 (EC:2.7.11.1) | Orotic Acid inhibits the reaction [STK11 protein results in decreased phosphorylation of RPS6KB1 protein] |
decreases phosphorylation
/ decreases reaction |
protein |
22863860
|
| D009963 | 6794 |
STK11
LKB1 PJS hLKB1 |
serine/threonine kinase 11 (EC:2.7.11.1) | Orotic Acid inhibits the reaction [STK11 protein results in increased phosphorylation of RPTOR protein] |
decreases reaction
/ increases phosphorylation |
protein |
22863860
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (16)
| OMIM | preferred title | UniProt |
|---|---|---|
| %606641 | Body mass index; bmi |
P37231
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #601665 | Obesity |
P37231
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
KEGG DISEASE (12)
| KEGG | disease name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|