PCIDB

KNApSAcK Metabolite C00002053

Metabolite

KNApSAcK Entry

id C00002053
Name (-)-Lobeline
CAS RN 90-69-7
Standard InChI InChI=1S/C22H27NO2/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18/h2-7,9-12,19-21,24H,8,13-16H2,1H3/t19-,20+,21-/m0/s1
Standard InChI (Main Layer) InChI=1S/C22H27NO2/c1-23-19(15-21(24)17-9-4-2-5-10-17)13-8-14-20(23)16-22(25)18-11-6-3-7-12-18/h2-7,9-12,19-21,24H,8,13-16H2,1H3

Cluster

Phytochemical cluster No. 1
KCF-S cluster No. 3195

Link

ChEMBL

By standard InChI CHEMBL122270
By standard InChI Main Layer CHEMBL15476 CHEMBL122270 CHEMBL1321415 CHEMBL1371478 CHEMBL1571589 CHEMBL2103769

KEGG

By LinkDB C07475

CTD

By CAS RN D008120

Human Protein / Gene in interaction

18 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1321415 CHEMBL1371478 CHEMBL1571589 CHEMBL2103769 CHEMBL754768 (1) CHEMBL1614110 (5)
CHEMBL1741321 (3)
1 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL122270 CHEMBL1794367 (1) CHEMBL2114784 (1)
1 / 1
P02545 Prelamin-A/C Unclassified protein CHEMBL122270 CHEMBL1614544 (1)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL1371478 CHEMBL1614361 (1)
3 / 2
P35367 Histamine H1 receptor Histamine receptor CHEMBL2103769 CHEMBL2169534 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1321415 CHEMBL1371478 CHEMBL1741325 (3)
0 / 1
P17787 Neuronal acetylcholine receptor subunit beta-2 CHRN beta CHEMBL122270 CHEMBL1948416 (1)
1 / 1
P43681 Neuronal acetylcholine receptor subunit alpha-4 CHRN alpha CHEMBL122270 CHEMBL1948416 (1)
1 / 1
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL122270 CHEMBL1613800 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL2103769 CHEMBL1794486 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL2103769 CHEMBL2114780 (1)
0 / 0
P36544 Neuronal acetylcholine receptor subunit alpha-7 CHRN alpha CHEMBL122270 CHEMBL1948415 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1321415 CHEMBL1371478 CHEMBL1741322 (3)
0 / 0
Q05940 Synaptic vesicular amine transporter Amine CHEMBL2103769 CHEMBL1068127 (1)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL1371478 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1321415 CHEMBL1371478 CHEMBL1741323 (3)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1321415 CHEMBL1371478 CHEMBL1741324 (3)
0 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL122270 CHEMBL1738442 (1)
0 / 0

CTD interaction (19)

compound gene gene name gene description interaction interaction type form reference
pmid
D008120 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D008120 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D008120 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D008120 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) Lobeline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
protein 14645658
D008120 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) Lobeline results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] affects binding
/ decreases activity
protein 14645658
D008120 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) CHRNA7 protein mutant form affects the susceptibility to Lobeline affects response to substance
protein 10082212
D008120 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) Lobeline binds to and results in decreased activity of CHRNA7 protein affects binding
/ decreases activity
protein 10082212
D008120 1139 CHRNA7
CHRNA7-2
NACHRA7
cholinergic receptor, nicotinic, alpha 7 (neuronal) Lobeline binds to and results in increased activity of CHRNA7 protein mutant form affects binding
/ increases activity
protein 10082212
D008120 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D008120 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D008120 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D008120 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) Lobeline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] affects binding
/ decreases reaction
protein 14645658
D008120 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) Lobeline results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] affects binding
/ decreases activity
protein 14645658
D008120 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D008120 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein] decreases phosphorylation
/ decreases reaction
protein 20106947
D008120 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D008120 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein] decreases phosphorylation
/ decreases reaction
protein 20106947
D008120 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] affects binding
/ decreases activity
/ decreases reaction
/ increases phosphorylation
protein 18448488
D008120 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) Lobeline inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] decreases reaction
/ increases phosphorylation
protein 20106947

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (19)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600513 Epilepsy, nocturnal frontal lobe, 1; enfl1 P43681
#605375 Epilepsy, nocturnal frontal lobe, 3; enfl3 P17787
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#275210 Restrictive dermopathy, lethal P02545
#183090 Spinocerebellar ataxia 2; sca2 Q99700

KEGG DISEASE (17)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00807 Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) P17787 (related)
P43681 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

5 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D019969 D008120 Amphetamine-Related Disorders therapeutic
11408539
D019970 D008120 Cocaine-Related Disorders therapeutic
16765386
D006948 D008120 Hyperkinesis therapeutic
12479946
D011595 D008120 Psychomotor Agitation therapeutic
16765386
D012640 D008120 Seizures marker/mechanism
6843794