PCIDB

KNApSAcK Metabolite C00002277

Metabolite

KNApSAcK Entry

id C00002277
Name Atropine
CAS RN 51-55-8
Standard InChI InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14?,15-,16+/m1/s1
Standard InChI (Main Layer) InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3

Cluster

Phytochemical cluster No. 1
KCF-S cluster No. 666

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL9751 CHEMBL517712 CHEMBL1257084 CHEMBL1331216 CHEMBL1379091 CHEMBL2112074

KEGG

By LinkDB C01479

CTD

By CAS RN D001285

Human Protein / Gene in interaction

110 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL517712 CHEMBL1379091 CHEMBL1741321 (3) CHEMBL1909136 (2)
CHEMBL2071965 (1)
1 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL517712 CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL517712 CHEMBL1014033 (1) CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL517712 CHEMBL1794573 (1) CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL517712 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL517712 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL517712 CHEMBL1909201 (2)
0 / 0
P06746 DNA polymerase beta Enzyme CHEMBL517712 CHEMBL1614079 (1)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL517712 CHEMBL1909176 (2)
0 / 0
P29466 Caspase-1 C14 CHEMBL517712 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL517712 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL517712 CHEMBL1909199 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL517712 CHEMBL1909197 (2)
2 / 2
O15245 Solute carrier family 22 member 1 Drug uniporter CHEMBL517712 CHEMBL993349 (1) CHEMBL994103 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL517712 CHEMBL1614310 (1)
11 / 10
P00918 Carbonic anhydrase 2 Lyase CHEMBL517712 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL517712 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL517712 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL517712 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL517712 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL517712 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL517712 CHEMBL686377 (1) CHEMBL683968 (1)
CHEMBL749215 (1) CHEMBL749216 (1)
CHEMBL749217 (1) CHEMBL749220 (1)
CHEMBL749221 (1) CHEMBL749222 (1)
CHEMBL749223 (1) CHEMBL744152 (1)
CHEMBL747674 (2) CHEMBL747675 (1)
CHEMBL744041 (1) CHEMBL749268 (1)
CHEMBL747005 (1) CHEMBL748452 (2)
CHEMBL748456 (2) CHEMBL748379 (1)
CHEMBL819452 (1) CHEMBL819453 (1)
CHEMBL819473 (1) CHEMBL843757 (1)
CHEMBL957809 (1) CHEMBL1248511 (1)
CHEMBL1831567 (1) CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL517712 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL517712 CHEMBL1909093 (2)
0 / 0
P02768 Serum albumin Secreted protein CHEMBL517712 CHEMBL702884 (1)
0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL517712 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL517712 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL517712 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL517712 CHEMBL1379091 CHEMBL1741325 (3) CHEMBL1909135 (2)
CHEMBL2071963 (1)
0 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL517712 CHEMBL1614522 (1) CHEMBL1614067 (1)
1 / 2
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL517712 CHEMBL1909203 (2)
1 / 11
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL517712 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL517712 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL517712 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL517712 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL517712 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL517712 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL517712 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL517712 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL517712 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL517712 CHEMBL1909166 (2)
1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL517712 CHEMBL1909133 (2)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL1379091 CHEMBL1738606 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL1331216 CHEMBL2114780 (1)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL517712 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL517712 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL517712 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL517712 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL517712 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL517712 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL517712 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL517712 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL517712 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL517712 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL517712 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL517712 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL517712 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL517712 CHEMBL1909110 (2)
1 / 0
P03956 Interstitial collagenase M10A CHEMBL517712 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL517712 CHEMBL1909119 (2)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL1379091 CHEMBL1794467 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL517712 CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL517712 CHEMBL686377 (1) CHEMBL683968 (1)
CHEMBL708885 (1) CHEMBL743979 (1)
CHEMBL749215 (1) CHEMBL749216 (1)
CHEMBL749217 (1) CHEMBL749220 (1)
CHEMBL749221 (1) CHEMBL749222 (1)
CHEMBL749223 (1) CHEMBL744152 (1)
CHEMBL747674 (2) CHEMBL747675 (1)
CHEMBL878663 (1) CHEMBL744041 (1)
CHEMBL745519 (1) CHEMBL749268 (1)
CHEMBL749950 (1) CHEMBL752397 (1)
CHEMBL747119 (1) CHEMBL745196 (1)
CHEMBL748452 (2) CHEMBL748456 (2)
CHEMBL752970 (1) CHEMBL748379 (1)
CHEMBL819452 (1) CHEMBL819453 (1)
CHEMBL819473 (1) CHEMBL843757 (1)
CHEMBL849039 (1) CHEMBL850549 (1)
CHEMBL840774 (1) CHEMBL1248508 (1)
CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL517712 CHEMBL686377 (1) CHEMBL683968 (1)
CHEMBL714431 (1) CHEMBL747398 (1)
CHEMBL743979 (1) CHEMBL749215 (1)
CHEMBL749216 (1) CHEMBL749217 (1)
CHEMBL749220 (1) CHEMBL749221 (1)
CHEMBL749222 (1) CHEMBL749223 (1)
CHEMBL744152 (1) CHEMBL744767 (1)
CHEMBL747674 (2) CHEMBL747675 (1)
CHEMBL744041 (1) CHEMBL749268 (1)
CHEMBL748054 (1) CHEMBL748452 (2)
CHEMBL748456 (2) CHEMBL745744 (1)
CHEMBL748379 (1) CHEMBL819452 (1)
CHEMBL819453 (1) CHEMBL819473 (1)
CHEMBL843757 (1) CHEMBL849039 (1)
CHEMBL840773 (1) CHEMBL1013935 (1)
CHEMBL1016624 (1) CHEMBL1909170 (2)
CHEMBL2166006 (1) CHEMBL2215470 (1)
CHEMBL2215474 (1)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL517712 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL517712 CHEMBL1909109 (2)
2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL517712 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL517712 CHEMBL686377 (1) CHEMBL683968 (1)
CHEMBL749215 (1) CHEMBL749216 (1)
CHEMBL749217 (1) CHEMBL749220 (1)
CHEMBL749221 (1) CHEMBL749222 (1)
CHEMBL749223 (1) CHEMBL744152 (1)
CHEMBL747674 (2) CHEMBL747675 (1)
CHEMBL744041 (1) CHEMBL749268 (1)
CHEMBL747818 (1) CHEMBL748452 (2)
CHEMBL748456 (2) CHEMBL748379 (1)
CHEMBL819452 (1) CHEMBL819453 (1)
CHEMBL819473 (1) CHEMBL843757 (1)
CHEMBL850549 (1) CHEMBL840773 (1)
CHEMBL840774 (1) CHEMBL1248509 (1)
CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL517712 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL517712 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL517712 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL517712 CHEMBL1909108 (2)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL517712 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL517712 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL517712 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL517712 CHEMBL1379091 CHEMBL1741322 (3) CHEMBL1909132 (2)
CHEMBL2071962 (1)
0 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein CHEMBL517712 CHEMBL1006005 (1)
1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL1331216 CHEMBL1738588 (1)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL517712 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL517712 CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL517712 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL517712 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL517712 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL517712 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL517712 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL517712 CHEMBL686377 (1) CHEMBL683968 (1)
CHEMBL749215 (1) CHEMBL749216 (1)
CHEMBL749217 (1) CHEMBL749220 (1)
CHEMBL749221 (1) CHEMBL749222 (1)
CHEMBL749223 (1) CHEMBL744152 (1)
CHEMBL747674 (2) CHEMBL747675 (1)
CHEMBL744041 (1) CHEMBL749268 (1)
CHEMBL749860 (1) CHEMBL748452 (2)
CHEMBL748456 (2) CHEMBL748379 (1)
CHEMBL819452 (1) CHEMBL819453 (1)
CHEMBL819473 (1) CHEMBL843757 (1)
CHEMBL1248510 (1) CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL517712 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL517712 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL517712 CHEMBL1909168 (2)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL1379091 CHEMBL1614274 (2) CHEMBL1613823 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL517712 CHEMBL1379091 CHEMBL1741323 (3) CHEMBL1909134 (2)
CHEMBL2071964 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL517712 CHEMBL1379091 CHEMBL1741324 (3) CHEMBL1909138 (2)
CHEMBL2071966 (1) CHEMBL2071967 (1)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL517712 CHEMBL1909137 (2)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL1331216 CHEMBL1794483 (1)
0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL517712 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL517712 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL517712 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL517712 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL517712 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL517712 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL517712 CHEMBL1909128 (2)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL517712 CHEMBL1613914 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL517712 CHEMBL1738442 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL517712 CHEMBL1614257 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL517712 CHEMBL1614257 (1)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL1379091 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL1379091 CHEMBL1613933 (1)
1 / 6
Q9NY46 Sodium channel protein type 3 subunit alpha SCN alpha, NaV1.x CHEMBL517712 CHEMBL806153 (1)
0 / 0
Q99250 Sodium channel protein type 2 subunit alpha SCN alpha, NaV1.x CHEMBL517712 CHEMBL806153 (1)
2 / 2
P35498 Sodium channel protein type 1 subunit alpha SCN alpha, NaV1.x CHEMBL517712 CHEMBL806153 (1)
3 / 2

CTD interaction (63)

compound gene gene name gene description interaction interaction type form reference
pmid
D001285 25 ABL1
ABL
JTK7
bcr/abl
c-ABL
p150
v-abl
c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) [Parathion co-treated with Atropine] results in increased expression of ABL1 mRNA affects cotreatment
/ increases expression
mRNA 17390078
D001285 43 ACHE
ACEE
ARACHE
N-ACHE
YT
acetylcholinesterase (EC:3.1.1.7) Atropine inhibits the reaction [[Organophosphorus Compounds results in decreased activity of ACHE protein] which results in increased abundance of Acetylcholine] decreases activity
/ decreases reaction
/ increases abundance
protein 20105433
D001285 43 ACHE
ACEE
ARACHE
N-ACHE
YT
acetylcholinesterase (EC:3.1.1.7) Atropine inhibits the reaction [Paraoxon results in increased expression of ACHE protein] decreases reaction
/ increases expression
protein 21787676
D001285 9564 BCAR1
CAS
CAS1
CASS1
CRKAS
P130Cas
breast cancer anti-estrogen resistance 1 Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 10537051
D001285 8900 CCNA1
cyclin A1 Atropine results in increased expression of CCNA1 mRNA increases expression
mRNA 17390078
D001285 8900 CCNA1
cyclin A1 [Parathion co-treated with Atropine] results in increased expression of CCNA1 mRNA affects cotreatment
/ increases expression
mRNA 17390078
D001285 896 CCND3
cyclin D3 [Parathion co-treated with Atropine] results in increased expression of CCND3 mRNA affects cotreatment
/ increases expression
mRNA 17390078
D001285 898 CCNE1
CCNE
cyclin E1 Atropine results in increased expression of CCNE1 mRNA increases expression
mRNA 17390078
D001285 898 CCNE1
CCNE
cyclin E1 [Parathion co-treated with Atropine] results in increased expression of CCNE1 mRNA affects cotreatment
/ increases expression
mRNA 17390078
D001285 9134 CCNE2
CYCE2
cyclin E2 Atropine results in increased expression of CCNE2 mRNA increases expression
mRNA 17390078
D001285 9134 CCNE2
CYCE2
cyclin E2 [Parathion co-treated with Atropine] results in increased expression of CCNE2 mRNA affects cotreatment
/ increases expression
mRNA 17390078
D001285 958 CD40
Bp50
CDW40
TNFRSF5
p50
CD40 molecule, TNF receptor superfamily member 5 Atropine inhibits the reaction [Carbachol results in increased expression of CD40 protein] decreases reaction
/ increases expression
protein 16879495
D001285 991 CDC20
CDC20A
bA276H19.3
p55CDC
cell division cycle 20 Atropine results in increased expression of CDC20 mRNA increases expression
mRNA 17390078
D001285 991 CDC20
CDC20A
bA276H19.3
p55CDC
cell division cycle 20 [Parathion co-treated with Atropine] results in increased expression of CDC20 mRNA affects cotreatment
/ increases expression
mRNA 17390078
D001285 990 CDC6
CDC18L
HsCDC18
HsCDC6
cell division cycle 6 [Parathion co-treated with Atropine] results in increased expression of CDC6 mRNA affects cotreatment
/ increases expression
mRNA 17390078
D001285 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) Atropine results in increased expression of CDK1 mRNA increases expression
mRNA 17390078
D001285 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) [Parathion co-treated with Atropine] results in increased expression of CDK1 mRNA affects cotreatment
/ increases expression
mRNA 17390078
D001285 1066 CES1
ACAT
CE-1
CEH
CES2
HMSE
HMSE1
PCE-1
REH
SES1
TGH
hCE-1
carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) Atropine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] decreases reaction
/ increases hydrolysis
protein 9311626
D001285 1128 CHRM1
HM1
M1
M1R
cholinergic receptor, muscarinic 1 Atropine affects the reaction [muscarinic toxin 7 binds to CHRM1 protein] affects binding
/ affects reaction
protein 16439611
D001285 1129 CHRM2
HM2
cholinergic receptor, muscarinic 2 Atropine binds to and results in decreased activity of CHRM2 protein affects binding
/ decreases activity
protein 15140916
D001285 1131 CHRM3
EGBRS
HM3
cholinergic receptor, muscarinic 3 Atropine binds to and results in decreased activity of CHRM3 protein affects binding
/ decreases activity
protein 15140916
D001285 1131 CHRM3
EGBRS
HM3
cholinergic receptor, muscarinic 3 Atropine inhibits the reaction [Carbachol results in increased activity of CHRM3 protein] decreases reaction
/ increases activity
protein 20708676
D001285 1132 CHRM4
HM4
M4R
cholinergic receptor, muscarinic 4 Atropine binds to CHRM4 protein affects binding
protein 16709648
D001285 1132 CHRM4
HM4
M4R
cholinergic receptor, muscarinic 4 [WIN 62577 co-treated with Quinuclidinyl Benzilate] inhibits the reaction [Atropine binds to CHRM4 protein] affects binding
/ affects cotreatment
/ decreases reaction
protein 16709648
D001285 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) Atropine binds to [CHRNA4 protein binds to CHRNB2 protein] affects binding
protein 15733544
D001285 1137 CHRNA4
BFNC
EBN
EBN1
NACHR
NACHRA4
NACRA4
cholinergic receptor, nicotinic, alpha 4 (neuronal) Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] affects activity
/ affects binding
/ increases reaction
protein 15733544
D001285 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) Atropine binds to [CHRNA4 protein binds to CHRNB2 protein] affects binding
protein 15733544
D001285 1141 CHRNB2
EFNL3
nAChRB2
cholinergic receptor, nicotinic, beta 2 (neuronal) Atropine promotes the reaction [Acetylcholine affects the activity of [CHRNA4 protein binds to CHRNB2 protein]] affects activity
/ affects binding
/ increases reaction
protein 15733544
D001285 1392 CRH
CRF
corticotropin releasing hormone [Atropine co-treated with SR 140333 co-treated with SR 48968] results in decreased activity of CRH protein affects cotreatment
/ decreases activity
protein 12906840
D001285 1499 CTNNB1
CTNNB
MRD19
armadillo
catenin (cadherin-associated protein), beta 1, 88kDa Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein] decreases reaction
/ increases expression
protein 17390078
D001285 1499 CTNNB1
CTNNB
MRD19
armadillo
catenin (cadherin-associated protein), beta 1, 88kDa Atropine inhibits the reaction [Parathion results in increased expression of CTNNB1 protein mutant form] decreases reaction
/ increases expression
protein 17390078
D001285 1856 DVL2
dishevelled segment polarity protein 2 Atropine inhibits the reaction [Parathion results in increased expression of DVL2 protein] decreases reaction
/ increases expression
protein 17390078
D001285 1906 EDN1
ET1
HDLCQ7
PPET1
endothelin 1 EDN1 protein results in decreased activity of [Atropine co-treated with Histamine] affects cotreatment
/ decreases activity
protein 12906840
D001285 1956 EGFR
ERBB
ERBB1
HER1
PIG61
mENA
epidermal growth factor receptor (EC:2.7.10.1) Atropine inhibits the reaction [Parathion results in increased expression of EGFR protein] decreases reaction
/ increases expression
protein 17390078
D001285 7430 EZR
CVIL
CVL
VIL2
ezrin Atropine inhibits the reaction [Parathion results in increased expression of EZR protein] decreases reaction
/ increases expression
protein 17390078
D001285 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Atropine inhibits the reaction [Paraoxon results in increased expression of FOS mRNA] decreases reaction
/ increases expression
mRNA 21787676
D001285 2741 GLRA1
HKPX1
STHE
glycine receptor, alpha 1 Atropine binds to and results in decreased activity of GLRA1 protein affects binding
/ decreases activity
protein 15081878
D001285 2914 GRM4
GPRC1D
MGLUR4
mGlu4
glutamate receptor, metabotropic 4 Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] affects binding
/ decreases reaction
/ increases activity
/ increases import
protein 18171729
D001285 3760 KCNJ3
GIRK1
KGA
KIR3.1
potassium inwardly-rectifying channel, subfamily J, member 3 Atropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium] affects binding
/ decreases reaction
/ increases activity
/ increases import
protein 18171729
D001285 3815 KIT
C-Kit
CD117
PBT
SCFR
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (EC:2.7.10.1) Atropine inhibits the reaction [Parathion results in increased expression of KIT protein] decreases reaction
/ increases expression
protein 17390078
D001285 4057 LTF
GIG12
HLF2
LF
lactotransferrin Atropine inhibits the reaction [methylcholine results in increased secretion of LTF protein] decreases reaction
/ increases secretion
protein 11112886
D001285 4173 MCM4
CDC21
CDC54
NKCD
NKGCD
P1-CDC21
hCdc21
minichromosome maintenance complex component 4 (EC:3.6.4.12) Atropine results in increased expression of MCM4 mRNA increases expression
mRNA 17390078
D001285 4173 MCM4
CDC21
CDC54
NKCD
NKGCD
P1-CDC21
hCdc21
minichromosome maintenance complex component 4 (EC:3.6.4.12) [Parathion co-treated with Atropine] results in increased expression of MCM4 mRNA affects cotreatment
/ increases expression
mRNA 17390078
D001285 4175 MCM6
MCG40308
Mis5
P105MCM
minichromosome maintenance complex component 6 (EC:3.6.4.12) Atropine results in increased expression of MCM6 mRNA increases expression
mRNA 17390078
D001285 4175 MCM6
MCG40308
Mis5
P105MCM
minichromosome maintenance complex component 6 (EC:3.6.4.12) [Parathion co-treated with Atropine] results in increased expression of MCM6 mRNA affects cotreatment
/ increases expression
mRNA 17390078
D001285 4855 NOTCH4
INT3
NOTCH3
notch 4 Atropine inhibits the reaction [Parathion results in increased expression of NOTCH4 protein] decreases reaction
/ increases expression
protein 17390078
D001285 5111 PCNA
proliferating cell nuclear antigen Atropine inhibits the reaction [Malathion results in increased expression of PCNA] decreases reaction
/ increases expression
12762645
D001285 5111 PCNA
proliferating cell nuclear antigen Atropine inhibits the reaction [Parathion results in increased expression of PCNA] decreases reaction
/ increases expression
12762645
D001285 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 10537051
D001285 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 10537051
D001285 5747 PTK2
FADK
FAK
FAK1
FRNK
PPP1R71
p125FAK
pp125FAK
protein tyrosine kinase 2 (EC:2.7.10.2) Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]] affects cotreatment
/ decreases reaction
/ increases phosphorylation
/ increases reaction
protein 10537051
D001285 5829 PXN
paxillin Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]] affects cotreatment
/ decreases reaction
/ increases phosphorylation
protein 10537051
D001285 5881 RAC3
ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) Atropine inhibits the reaction [Parathion results in increased expression of RAC3 protein] decreases reaction
/ increases expression
protein 17390078
D001285 387 RHOA
ARH12
ARHA
RHO12
RHOH12
ras homolog family member A Atropine inhibits the reaction [Parathion results in increased expression of RHOA protein] decreases reaction
/ increases expression
protein 17390078
D001285 6580 SLC22A1
HOCT1
OCT1
oct1_cds
solute carrier family 22 (organic cation transporter), member 1 Atropine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium] decreases reaction
/ increases transport
protein 16263091
D001285 6580 SLC22A1
HOCT1
OCT1
oct1_cds
solute carrier family 22 (organic cation transporter), member 1 Atropine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] decreases reaction
/ increases uptake
protein 21641380
D001285 6582 SLC22A2
OCT2
solute carrier family 22 (organic cation transporter), member 2 Atropine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium] decreases reaction
/ increases transport
protein 16263091
D001285 6581 SLC22A3
EMT
EMTH
OCT3
solute carrier family 22 (organic cation transporter), member 3 Atropine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium] decreases reaction
/ increases transport
protein 16263091
D001285 6581 SLC22A3
EMT
EMTH
OCT3
solute carrier family 22 (organic cation transporter), member 3 SLC22A3 protein results in increased uptake of Atropine increases uptake
protein 16263091
D001285 6583 SLC22A4
OCTN1
solute carrier family 22 (organic cation/zwitterion transporter), member 4 Atropine inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] decreases reaction
/ increases uptake
protein 21641380
D001285 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein] decreases reaction
/ increases expression
protein 12762645
D001285 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Atropine inhibits the reaction [Parathion results in increased expression of TP53 protein] decreases reaction
/ increases expression
protein 12762645
D001285 7204 TRIO
ARHGEF23
tgat
trio Rho guanine nucleotide exchange factor (EC:2.7.11.1) Atropine inhibits the reaction [Parathion results in increased expression of TRIO protein] decreases reaction
/ increases expression
protein 17390078

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (58)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#210900 Bloom syndrome; blm P54132
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#607208 Dravet syndrome P35498
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#613721 Epileptic encephalopathy, early infantile, 11; eiee11 Q99250
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#604403 Generalized epilepsy with febrile seizures plus, type 2; gefsp2 P35498
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#609634 Migraine, familial hemiplegic, 3; fhm3 P35498
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#607745 Seizures, benign familial infantile, 3; bfis3 Q99250
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (58)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00775 Familial or sporadic hemiplegic migraine P35498 (related)
H00783 Febrile seizures P35498 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00208 Hyperbilirubinemia Q92887 (related)
H00606 Early infantile epileptic encephalopathy Q99250 (related)
H00806 Benign familial neonatal and infantile epilepsies Q99250 (related)

Diseases related to CTD interactions

99 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000647 D001285 Amnesia marker/mechanism
16174677
D020236 D001285 Amnesia, Transient Global marker/mechanism
17698416
D000787 D001285 Angina Pectoris therapeutic
6305298
D000855 D001285 Anorexia therapeutic
1363306
D056988 D001285 Anterior Wall Myocardial Infarction marker/mechanism
9691421
D001049 D001285 Apnea marker/mechanism
therapeutic
20912
1855619
4326672
16953949
D001145 D001285 Arrhythmias, Cardiac marker/mechanism
therapeutic
4857
26160
278459
1684074
3149155
6239562
8280339
17628422
D001146 D001285 Arrhythmia, Sinus therapeutic
9631874
D001281 D001285 Atrial Fibrillation marker/mechanism
therapeutic
9489317
11282081
17073912
18980425
D054537 D001285 Atrioventricular Block marker/mechanism
therapeutic
2778956
3510989
17711430
18282259
19008069
D001919 D001285 Bradycardia marker/mechanism
therapeutic
278459
937392
1413473
1684074
1867419
2122504
2213551
3234460
3263874
3301078
3341694
3414927
3525850
3537354
3675083
3749546
6123873
6230022
6251761
6466532
6510469
6762901
6831652
7803758
8302145
8489673
8534470
8958495
10713875
10756546
10995163
11089775
11149715
11181912
11320466
11740913
15762916
15795184
16803915
16953949
18282259
19008069
19675280
19834416
20533121
D001943 D001285 Breast Neoplasms therapeutic
12762645
D001982 D001285 Bronchial Diseases therapeutic
9851584
D002375 D001285 Catalepsy marker/mechanism
therapeutic
10058
40649
403561
987911
1033567
1172421
1239323
3925479
4279348
6540616
6891961
10958255
11900788
12907310
16047547
D002385 D001285 Cataplexy therapeutic
8008205
D002561 D001285 Cerebrovascular Disorders therapeutic
15009014
D002637 D001285 Chest Pain marker/mechanism
8892787
17262096
D019970 D001285 Cocaine-Related Disorders therapeutic
20393457
D003128 D001285 COMA marker/mechanism
12455330
D003329 D001285 Coronary Vasospasm marker/mechanism
8892787
17262096
D006259 D001285 Craniocerebral Trauma therapeutic
20816720
D003693 D001285 Delirium marker/mechanism
5102638
D003967 D001285 Diarrhea therapeutic
10867622
D056486 D001285 Drug-Induced Liver Injury marker/mechanism
22331495
D062787 D001285 Drug Overdose therapeutic
9711203
9928640
D064420 D001285 Drug-Related Side Effects and Adverse Reactions therapeutic
3414927
12461832
D004381 D001285 Duodenal Ulcer therapeutic
11595415
D020820 D001285 Dyskinesias therapeutic
21791372
D004831 D001285 Epilepsies, Myoclonic therapeutic
1620139
D004827 D001285 Epilepsy therapeutic
4058572
D004830 D001285 Epilepsy, Tonic-Clonic marker/mechanism
4092617
D007172 D001285 Erectile Dysfunction therapeutic
10098948
D005334 D001285 Fever marker/mechanism
18719317
D005483 D001285 Flushing marker/mechanism
1867419
D005767 D001285 Gastrointestinal Diseases therapeutic
18467537
D006212 D001285 Hallucinations marker/mechanism
707647
D006261 D001285 Headache marker/mechanism
therapeutic
5354796
6928283
D006323 D001285 Heart Arrest marker/mechanism
therapeutic
2699785
6383137
7119638
17907030
D006327 D001285 Heart Block therapeutic
11149715
16506357
D006342 D001285 Heart Rupture, Post-Infarction marker/mechanism
10668020
D006940 D001285 Hyperemia marker/mechanism
therapeutic
12468513
15009014
D006943 D001285 Hyperglycemia therapeutic
22305719
D006973 D001285 Hypertension marker/mechanism
therapeutic
978847
1855619
3149155
3559705
3996883
6230022
8534470
11149715
12455330
15795184
17628422
18719317
18831911
D007008 D001285 Hypokalemia marker/mechanism
3168573
D007022 D001285 Hypotension marker/mechanism
therapeutic
538435
1352931
2122504
2168244
3720002
4186181
6510843
7864443
7915249
9180623
9489317
10190394
10713875
11740913
16803915
16984954
17351238
17628422
18282259
20533121
D007035 D001285 Hypothermia marker/mechanism
18719317
D007249 D001285 Inflammation therapeutic
22245128
D007410 D001285 Intestinal Diseases therapeutic
16944022
D007859 D001285 Learning Disorders marker/mechanism
7886078
D008133 D001285 Long QT Syndrome marker/mechanism
17666066
D015877 D001285 Miosis therapeutic
22247005
D009127 D001285 Muscle Rigidity marker/mechanism
4124577
9017254
D018908 D001285 Muscle Weakness therapeutic
3738227
D009135 D001285 Muscular Diseases therapeutic
12451448
D009140 D001285 Musculoskeletal Diseases therapeutic
6724209
D009157 D001285 Myasthenia Gravis therapeutic
4739612
D015878 D001285 Mydriasis marker/mechanism
2620933
11878186
14620526
16104118
22247005
D009203 D001285 Myocardial Infarction marker/mechanism
11765483
D017202 D001285 Myocardial Ischemia marker/mechanism
9691421
15220898
15670093
D009207 D001285 Myoclonus therapeutic
526383
1620139
7078834
D009216 D001285 Myopia therapeutic
12601066
D009325 D001285 Nausea marker/mechanism
6711256
D009336 D001285 Necrosis therapeutic
6724209
D009422 D001285 Nervous System Diseases therapeutic
22796677
D020258 D001285 Neurotoxicity Syndromes therapeutic
16536121
D062025 D001285 Organophosphate Poisoning therapeutic
1276991
1664807
1949606
3738227
3761745
20581384
D010243 D001285 Paralysis therapeutic
2564745
6130710
9067054
D010437 D001285 Peptic Ulcer therapeutic
7034155
D010554 D001285 Personality Disorders marker/mechanism
145765
D011041 D001285 Poisoning marker/mechanism
therapeutic
5644266
11730559
12046725
16778709
17849254
18072136
18547553
20138854
20156430
20167212
20230808
20433814
20599844
21771644
D011183 D001285 Postoperative Complications marker/mechanism
5102638
D020250 D001285 Postoperative Nausea and Vomiting therapeutic
58198
D011297 D001285 Prenatal Exposure Delayed Effects marker/mechanism
3988167
D011654 D001285 Pulmonary Edema therapeutic
19675280
D012021 D001285 Reflex, Abnormal marker/mechanism
11920928
D012120 D001285 Respiration Disorders therapeutic
3738227
D012131 D001285 Respiratory Insufficiency marker/mechanism
3422794
D012640 D001285 Seizures marker/mechanism
therapeutic
65671
444350
1172421
1933276
6301005
8028781
8224101
8434764
11074189
11218047
12660363
14975695
15036754
15919102
16962289
17157343
18719317
21097996
21600273
22245128
22796677
D054138 D001285 Sinus Arrest, Cardiac therapeutic
8534470
16167799
D013226 D001285 Status Epilepticus therapeutic
3582562
3612132
3948956
8817469
19111886
20498005
22245128
D013276 D001285 Stomach Ulcer therapeutic
3865005
11595415
16804302
D053608 D001285 Stupor marker/mechanism
22245128
D013375 D001285 Substance Withdrawal Syndrome marker/mechanism
8829152
D013575 D001285 Syncope therapeutic
7056119
D013610 D001285 Tachycardia marker/mechanism
therapeutic
278459
2570522
3720002
3775101
3996883
6696128
6831652
6849777
7472763
11668046
11740913
15670093
18719317
18831911
D013611 D001285 Tachycardia, Atrioventricular Nodal Reentry marker/mechanism
11752915
D013616 D001285 Tachycardia, Sinus marker/mechanism
10707131
D013617 D001285 Tachycardia, Supraventricular marker/mechanism
10190394
11767035
18594552
D017180 D001285 Tachycardia, Ventricular marker/mechanism
10190394
D016171 D001285 Torsades de Pointes therapeutic
7056119
9505930
D014202 D001285 Tremor therapeutic
2354039
2984330
6791238
8205054
9231353
10683491
11981227
15990178
17594079
D053201 D001285 Urinary Bladder, Overactive therapeutic
7164219
D014555 D001285 Urination Disorders marker/mechanism
6711256
D014607 D001285 Uveomeningoencephalitic Syndrome therapeutic
20177954
D020421 D001285 Vagus Nerve Diseases marker/mechanism
3627083
D014693 D001285 Ventricular Fibrillation marker/mechanism
4044492
8892787
9691421
18594552
D014786 D001285 Vision Disorders therapeutic
22247005
D014839 D001285 Vomiting marker/mechanism
6711256
D014987 D001285 Xerostomia marker/mechanism
16104118