KNApSAcK Metabolite C00002285
Metabolite
KNApSAcK Entry
| id | C00002285 |
|---|---|
| Name | Cocaine |
| CAS RN | 50-36-2 |
| Standard InChI | InChI=1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13?,14+,15?/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C17H21NO4/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3 |
Cluster
| Phytochemical cluster | No. 1 |
|---|---|
| KCF-S cluster | No. 4208 |
Link
ChEMBL
| By standard InChI | CHEMBL369375 |
|---|---|
| By standard InChI Main Layer | CHEMBL32363 CHEMBL340560 CHEMBL120330 CHEMBL352487 CHEMBL170745 CHEMBL171201 CHEMBL352575 CHEMBL171007 CHEMBL369375 CHEMBL370805 CHEMBL1882521 CHEMBL2112004 |
KEGG
| By LinkDB | C01416 |
|---|
CTD
| By CAS RN | D003042 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| rosids | 1 |
Family
| family name | count |
|---|---|
| Erythroxylaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Erythroxylum coca | 289672 | Erythroxylaceae | rosids | Viridiplantae |
Human Protein / Gene in interaction
5 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | CHEMBL32363 |
CHEMBL1676103
(1)
|
2 / 2 |
| O75496 | Geminin | Unclassified protein | CHEMBL32363 CHEMBL1882521 |
CHEMBL2114843
(1)
CHEMBL2114780
(1)
|
0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | CHEMBL1882521 |
CHEMBL2114788
(1)
|
0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | CHEMBL32363 |
CHEMBL1738588
(1)
|
0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | CHEMBL32363 |
CHEMBL1614250
(1)
|
4 / 3 |
CTD interaction (387)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D003042 | 1636 |
ACE
ACE1 CD143 DCP DCP1 ICH MVCD3 |
angiotensin I converting enzyme (EC:3.4.15.1) | ACE inhibits the reaction [Cocaine affects the abundance of Dinoprostone] |
affects abundance
/ decreases reaction |
14738173
|
|
| D003042 | 1636 |
ACE
ACE1 CD143 DCP DCP1 ICH MVCD3 |
angiotensin I converting enzyme (EC:3.4.15.1) | ACE inhibits the reaction [Cocaine affects the abundance of Epoprostenol] |
affects abundance
/ decreases reaction |
14738173
|
|
| D003042 | 72 |
ACTG2
ACT ACTA3 ACTE ACTL3 ACTSG |
actin, gamma 2, smooth muscle, enteric | Cocaine results in decreased expression of ACTG2 mRNA |
decreases expression
|
mRNA |
20948987
|
| D003042 | 88 |
ACTN2
CMD1AA |
actinin, alpha 2 | Cocaine results in increased expression of ACTN2 mRNA |
increases expression
|
mRNA |
15009677
16710320 |
| D003042 | 83543 |
AIF1L
C9orf58 IBA2 |
allograft inflammatory factor 1-like | Cocaine results in decreased expression of AIF1L mRNA |
decreases expression
|
mRNA |
15009677
|
| D003042 | 9131 |
AIFM1
AIF CMTX4 COWCK COXPD6 PDCD8 |
apoptosis-inducing factor, mitochondrion-associated, 1 | Cocaine results in increased expression of AIFM1 mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 203 |
AK1
|
adenylate kinase 1 (EC:2.7.4.3 2.7.4.6) | Cocaine results in decreased expression of AK1 mRNA |
decreases expression
|
mRNA |
15009677
|
| D003042 | 1175 |
AP2S1
AP17 AP17-DELTA CLAPS2 HHC3 |
adaptor-related protein complex 2, sigma 1 subunit | Cocaine results in decreased expression of AP2S1 mRNA |
decreases expression
|
mRNA |
15009677
|
| D003042 | 325 |
APCS
PTX2 SAP |
amyloid P component, serum | Cocaine results in increased expression of APCS protein |
increases expression
|
protein |
12714198
|
| D003042 | 23780 |
APOL2
APOL-II APOL3 |
apolipoprotein L, 2 | Cocaine results in increased expression of APOL2 mRNA |
increases expression
|
mRNA |
17205118
|
| D003042 | 351 |
APP
AAA ABETA ABPP AD1 APPI CTFgamma CVAP PN-II PN2 |
amyloid beta (A4) precursor protein | Cocaine results in increased expression of APP mRNA |
increases expression
|
mRNA |
15009677
16710320 |
| D003042 | 9411 |
ARHGAP29
PARG1 RP11-255E17.1 |
Rho GTPase activating protein 29 | Cocaine results in decreased expression of ARHGAP29 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 498 |
ATP5A1
ATP5A ATP5AL2 ATPM MC5DN4 MOM2 OMR ORM hATP1 |
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle | Cocaine affects the expression of ATP5A1 protein |
affects expression
|
protein |
19393250
|
| D003042 | 506 |
ATP5B
ATPMB ATPSB |
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide (EC:3.6.3.14) | Cocaine results in decreased expression of ATP5B protein |
decreases expression
|
protein |
17075605
|
| D003042 | 518 |
ATP5G3
P3 |
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) | Cocaine results in decreased expression of ATP5G3 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 374868 |
ATP9B
ATPASEP ATPIIB NEO1L hMMR1 |
ATPase, class II, type 9B (EC:3.6.3.1) | ATP9B gene SNP affects the susceptibility to Cocaine |
affects response to substance
|
gene |
18438686
|
| D003042 | 4287 |
ATXN3
AT3 ATX3 JOS MJD MJD1 SCA3 |
ataxin 3 (EC:3.4.19.12) | Cocaine results in decreased expression of ATXN3 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 581 |
BAX
BCL2L4 |
BCL2-associated X protein | Cocaine results in increased expression of BAX mRNA |
increases expression
|
mRNA |
20948987
|
| D003042 | 590 |
BCHE
CHE1 CHE2 E1 |
butyrylcholinesterase (EC:3.1.1.8) | BCHE protein affects the hydrolysis of Cocaine |
affects hydrolysis
|
protein |
16275916
18514178 |
| D003042 | 590 |
BCHE
CHE1 CHE2 E1 |
butyrylcholinesterase (EC:3.1.1.8) | BCHE protein affects the metabolism of Cocaine |
affects metabolic processing
|
protein |
18514640
|
| D003042 | 590 |
BCHE
CHE1 CHE2 E1 |
butyrylcholinesterase (EC:3.1.1.8) | BCHE protein modified form results in increased hydrolysis of Cocaine |
increases hydrolysis
|
protein |
18514178
|
| D003042 | 590 |
BCHE
CHE1 CHE2 E1 |
butyrylcholinesterase (EC:3.1.1.8) | BCHE protein mutant form affects the degradation of Cocaine |
affects degradation
|
protein |
17989928
|
| D003042 | 590 |
BCHE
CHE1 CHE2 E1 |
butyrylcholinesterase (EC:3.1.1.8) | BCHE protein mutant form results in decreased metabolism of Cocaine |
decreases metabolic processing
|
protein |
572161
|
| D003042 | 590 |
BCHE
CHE1 CHE2 E1 |
butyrylcholinesterase (EC:3.1.1.8) | BCHE protein mutant form results in decreased susceptibility to Cocaine |
decreases response to substance
|
protein |
20971807
|
| D003042 | 590 |
BCHE
CHE1 CHE2 E1 |
butyrylcholinesterase (EC:3.1.1.8) | BCHE protein mutant form results in increased hydrolysis of Cocaine |
increases hydrolysis
|
protein |
16275916
20060817 |
| D003042 | 590 |
BCHE
CHE1 CHE2 E1 |
butyrylcholinesterase (EC:3.1.1.8) | BCHE protein mutant form results in increased metabolism of Cocaine |
increases metabolic processing
|
protein |
20219449
|
| D003042 | 590 |
BCHE
CHE1 CHE2 E1 |
butyrylcholinesterase (EC:3.1.1.8) | BCHE protein results in increased metabolism of Cocaine |
increases metabolic processing
|
protein |
19067679
|
| D003042 | 627 |
BDNF
ANON2 BULN2 |
brain-derived neurotrophic factor | BDNF mRNA results in decreased susceptibility to Cocaine |
decreases response to substance
|
mRNA |
17194538
|
| D003042 | 627 |
BDNF
ANON2 BULN2 |
brain-derived neurotrophic factor | BDNF protein results in decreased susceptibility to Cocaine |
decreases response to substance
|
protein |
17194538
|
| D003042 | 801 |
CALM1
CALML2 CAMI CPVT4 DD132 PHKD caM |
calmodulin 1 (phosphorylase kinase, delta) (EC:2.7.11.19) | Cocaine results in decreased expression of CALM1 mRNA |
decreases expression
|
mRNA |
17205118
|
| D003042 | 805 |
CALM2
CAMII PHKD PHKD2 |
calmodulin 2 (phosphorylase kinase, delta) (EC:2.7.11.19) | Cocaine results in decreased expression of CALM2 mRNA |
decreases expression
|
mRNA |
17205118
|
| D003042 | 816 |
CAMK2B
CAM2 CAMK2 CAMKB |
calcium/calmodulin-dependent protein kinase II beta (EC:2.7.11.17) | Cocaine results in decreased expression of CAMK2B mRNA |
decreases expression
|
mRNA |
17205118
|
| D003042 | 814 |
CAMK4
CaMK_IV CaMK-GR IV caMK |
calcium/calmodulin-dependent protein kinase IV (EC:2.7.11.17) | CAMK4 promoter SNP results in increased susceptibility to Cocaine |
increases response to substance
|
promoter |
19001277
|
| D003042 | 832 |
CAPZB
CAPB CAPPB CAPZ |
capping protein (actin filament) muscle Z-line, beta | Cocaine results in decreased expression of CAPZB mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 9607 |
CARTPT
CART |
CART prepropeptide | Cocaine results in increased expression of CARTPT mRNA |
increases expression
|
mRNA |
15009677
|
| D003042 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Cocaine results in increased expression of CASP3 protein |
increases expression
|
protein |
16686379
|
| D003042 | 837 |
CASP4
ICE(rel)II ICEREL-II ICH-2 Mih1/TX TX |
caspase 4, apoptosis-related cysteine peptidase (EC:3.4.22.57) | Cocaine results in decreased expression of CASP4 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 842 |
CASP9
APAF-3 APAF3 ICE-LAP6 MCH6 PPP1R56 |
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) | Cocaine results in increased expression of CASP9 protein |
increases expression
|
protein |
16686379
|
| D003042 | 887 |
CCKBR
CCK-B CCK2R GASR |
cholecystokinin B receptor | Cocaine results in decreased expression of CCKBR mRNA |
decreases expression
|
mRNA |
18000554
|
| D003042 | 6347 |
CCL2
GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF |
chemokine (C-C motif) ligand 2 | Cocaine results in increased secretion of CCL2 protein |
increases secretion
|
protein |
10065903
|
| D003042 | 6348 |
CCL3
G0S19-1 LD78ALPHA MIP-1-alpha MIP1A SCYA3 |
chemokine (C-C motif) ligand 3 | Cocaine results in increased secretion of CCL3 protein |
increases secretion
|
protein |
10065903
|
| D003042 | 890 |
CCNA2
CCN1 CCNA |
cyclin A2 | Cocaine results in decreased expression of CCNA2 mRNA |
decreases expression
|
mRNA |
18593214
|
| D003042 | 1234 |
CCR5
CC-CKR-5 CCCKR5 CCR-5 CD195 CKR-5 CKR5 CMKBR5 IDDM22 |
chemokine (C-C motif) receptor 5 (gene/pseudogene) | Cocaine results in increased expression of CCR5 protein |
increases expression
|
protein |
16204638
|
| D003042 | 401145 |
CCSER1
FAM190A |
coiled-coil serine-rich protein 1 | CCSER1 gene SNP affects the susceptibility to Cocaine |
affects response to substance
|
gene |
18438686
|
| D003042 | 51622 |
CCZ1
C7orf28A CCZ1A H_DJ1163J12.2 |
CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae) | Cocaine results in decreased expression of CCZ1 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 960 |
CD44
CDW44 CSPG8 ECMR-III HCELL HUTCH-I IN LHR MC56 MDU2 MDU3 MIC4 Pgp1 |
CD44 molecule (Indian blood group) | Cocaine results in decreased expression of CD44 mRNA |
decreases expression
|
mRNA |
18000554
|
| D003042 | 975 |
CD81
CVID6 S5.7 TAPA1 TSPAN28 |
CD81 molecule | CD81 protein results in increased susceptibility to Cocaine |
increases response to substance
|
protein |
15715673
|
| D003042 | 999 |
CDH1
Arc-1 CD324 CDHE ECAD LCAM UVO |
cadherin 1, type 1, E-cadherin (epithelial) | Cocaine results in decreased expression of CDH1 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 1015 |
CDH17
CDH16 HPT-1 HPT1 |
cadherin 17, LI cadherin (liver-intestine) | Cocaine results in decreased expression of CDH17 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 1066 |
CES1
ACAT CE-1 CEH CES2 HMSE HMSE1 PCE-1 REH SES1 TGH hCE-1 |
carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) | CES1 protein results in increased hydrolysis of Cocaine |
increases hydrolysis
|
protein |
9311626
12679808 12773168 |
| D003042 | 1066 |
CES1
ACAT CE-1 CEH CES2 HMSE HMSE1 PCE-1 REH SES1 TGH hCE-1 |
carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) | CES1 protein results in increased metabolism of [Cocaine co-treated with Ethanol] |
affects cotreatment
/ increases metabolic processing |
protein |
9311626
12773168 |
| D003042 | 1066 |
CES1
ACAT CE-1 CEH CES2 HMSE HMSE1 PCE-1 REH SES1 TGH hCE-1 |
carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) | Cocaine binds to CES1 protein |
affects binding
|
protein |
9311626
|
| D003042 | 1066 |
CES1
ACAT CE-1 CEH CES2 HMSE HMSE1 PCE-1 REH SES1 TGH hCE-1 |
carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) | Cocaine inhibits the reaction [CES1 protein results in increased chemical synthesis of 6-O-monoacetylmorphine] |
decreases reaction
/ increases chemical synthesis |
protein |
8930175
|
| D003042 | 1066 |
CES1
ACAT CE-1 CEH CES2 HMSE HMSE1 PCE-1 REH SES1 TGH hCE-1 |
carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) | Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-methylumbelliferyl acetate] |
decreases reaction
/ increases hydrolysis |
protein |
9311626
|
| D003042 | 1066 |
CES1
ACAT CE-1 CEH CES2 HMSE HMSE1 PCE-1 REH SES1 TGH hCE-1 |
carboxylesterase 1 (EC:3.1.1.1 3.1.1.56) | Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of Heroin] |
decreases reaction
/ increases hydrolysis |
protein |
8930175
|
| D003042 | 8824 |
CES2
CE-2 CES2A1 PCE-2 iCE |
carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56) | CES2 protein results in increased hydrolysis of Cocaine |
increases hydrolysis
|
protein |
9169443
|
| D003042 | 8824 |
CES2
CE-2 CES2A1 PCE-2 iCE |
carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56) | Cocaine inhibits the reaction [CES2 protein results in increased chemical synthesis of 6-O-monoacetylmorphine] |
decreases reaction
/ increases chemical synthesis |
protein |
8930175
|
| D003042 | 8824 |
CES2
CE-2 CES2A1 PCE-2 iCE |
carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56) | Cocaine inhibits the reaction [CES2 protein results in increased chemical synthesis of Morphine] |
decreases reaction
/ increases chemical synthesis |
protein |
8930175
|
| D003042 | 8824 |
CES2
CE-2 CES2A1 PCE-2 iCE |
carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56) | Cocaine inhibits the reaction [CES2 protein results in increased hydrolysis of 6-O-monoacetylmorphine] |
decreases reaction
/ increases hydrolysis |
protein |
8930175
|
| D003042 | 8824 |
CES2
CE-2 CES2A1 PCE-2 iCE |
carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56) | Cocaine inhibits the reaction [CES2 protein results in increased hydrolysis of Heroin] |
decreases reaction
/ increases hydrolysis |
protein |
8930175
|
| D003042 | 8824 |
CES2
CE-2 CES2A1 PCE-2 iCE |
carboxylesterase 2 (EC:3.1.1.1 3.1.1.84 3.1.1.56) | Cocaine results in decreased expression of CES2 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 1138 |
CHRNA5
LNCR2 |
cholinergic receptor, nicotinic, alpha 5 (neuronal) | CHRNA5 gene polymorphism results in decreased susceptibility to Cocaine |
decreases response to substance
|
gene |
18519132
|
| D003042 | 91612 |
CHURC1
C14orf52 chch |
churchill domain containing 1 | Cocaine results in decreased expression of CHURC1 mRNA |
decreases expression
|
mRNA |
15009677
16710320 |
| D003042 | 1152 |
CKB
B-CK CKBB |
creatine kinase, brain (EC:2.7.3.2) | Cocaine results in increased secretion of [CKB protein binds to CKM protein] |
affects binding
/ increases secretion |
protein |
12359538
|
| D003042 | 1158 |
CKM
CKMM M-CK |
creatine kinase, muscle (EC:2.7.3.2) | Cocaine results in increased secretion of [CKB protein binds to CKM protein] |
affects binding
/ increases secretion |
protein |
12359538
|
| D003042 | 5010 |
CLDN11
OSP OTM |
claudin 11 | Cocaine results in decreased expression of CLDN11 mRNA |
decreases expression
|
mRNA |
18357522
|
| D003042 | 1192 |
CLIC1
G6 NCC27 |
chloride intracellular channel 1 | Cocaine results in decreased expression of CLIC1 mRNA |
decreases expression
|
mRNA |
18000554
|
| D003042 | 6249 |
CLIP1
CLIP CLIP-170 CLIP170 CYLN1 RSN |
CAP-GLY domain containing linker protein 1 | Cocaine results in increased expression of CLIP1 mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 1212 |
CLTB
LCB |
clathrin, light chain B | Cocaine results in decreased expression of CLTB mRNA |
decreases expression
|
mRNA |
12629581
15009677 |
| D003042 | 22866 |
CNKSR2
CNK2 KSR2 MAGUIN |
connector enhancer of kinase suppressor of Ras 2 | Cocaine results in increased expression of CNKSR2 mRNA |
increases expression
|
mRNA |
15009677
|
| D003042 | 1268 |
CNR1
CANN6 CB-R CB1 CB1A CB1K5 CB1R CNR |
cannabinoid receptor 1 (brain) | CNR1 gene polymorphism affects the susceptibility to Cocaine |
affects response to substance
|
gene |
16314880
|
| D003042 | 1268 |
CNR1
CANN6 CB-R CB1 CB1A CB1K5 CB1R CNR |
cannabinoid receptor 1 (brain) | CNR1 gene SNP affects the susceptibility to Cocaine |
affects response to substance
|
gene |
19052543
|
| D003042 | 1268 |
CNR1
CANN6 CB-R CB1 CB1A CB1K5 CB1R CNR |
cannabinoid receptor 1 (brain) | CNR1 polymorphism affects the susceptibility to Cocaine |
affects response to substance
|
polymorphism |
9106242
|
| D003042 | 81578 |
COL21A1
COLA1L dJ682J15.1 dJ708F5.1 |
collagen, type XXI, alpha 1 | COL21A1 gene SNP affects the susceptibility to Cocaine |
affects response to substance
|
gene |
18438686
|
| D003042 | 1345 |
COX6C
|
cytochrome c oxidase subunit VIc (EC:1.9.3.1) | Cocaine results in decreased expression of COX6C mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 1401 |
CRP
PTX1 |
C-reactive protein, pentraxin-related | Cocaine results in increased expression of CRP protein |
increases expression
|
protein |
11988210
|
| D003042 | 1410 |
CRYAB
CMD1II CRYA2 CTPP2 CTRCT16 HSPB5 MFM2 |
crystallin, alpha B | Cocaine results in decreased expression of CRYAB mRNA |
decreases expression
|
mRNA |
15009677
|
| D003042 | 1415 |
CRYBB2
CCA2 CRYB2 CRYB2A CTRCT3 D22S665 |
crystallin, beta B2 | Cocaine results in decreased expression of CRYBB2 mRNA |
decreases expression
|
mRNA |
15009677
|
| D003042 | 1466 |
CSRP2
CRP2 LMO5 SmLIM |
cysteine and glycine-rich protein 2 | Cocaine results in decreased expression of CSRP2 mRNA |
decreases expression
|
mRNA |
18000554
|
| D003042 | 1490 |
CTGF
CCN2 HCS24 IGFBP8 NOV2 |
connective tissue growth factor | Cocaine results in decreased expression of CTGF mRNA |
decreases expression
|
mRNA |
18000554
|
| D003042 | 1490 |
CTGF
CCN2 HCS24 IGFBP8 NOV2 |
connective tissue growth factor | Cocaine results in decreased expression of CTGF protein |
decreases expression
|
protein |
18000554
|
| D003042 | 56998 |
CTNNBIP1
ICAT |
catenin, beta interacting protein 1 | Cocaine results in decreased expression of CTNNBIP1 mRNA |
decreases expression
|
mRNA |
18000554
|
| D003042 | 1501 |
CTNND2
GT24 NPRAP |
catenin (cadherin-associated protein), delta 2 | Cocaine results in decreased expression of CTNND2 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 8450 |
CUL4B
MRXHF2 MRXS15 MRXSC SFM2 |
cullin 4B | Cocaine results in increased expression of CUL4B mRNA |
increases expression
|
mRNA |
15009677
|
| D003042 | 3627 |
CXCL10
C7 IFI10 INP10 IP-10 SCYB10 crg-2 gIP-10 mob-1 |
chemokine (C-X-C motif) ligand 10 | Cocaine results in increased secretion of CXCL10 protein |
increases secretion
|
protein |
10065903
|
| D003042 | 7852 |
CXCR4
CD184 D2S201E FB22 HM89 HSY3RR LAP3 LCR1 LESTR NPY3R NPYR NPYRL NPYY3R WHIM |
chemokine (C-X-C motif) receptor 4 | Cocaine results in increased expression of CXCR4 protein |
increases expression
|
protein |
16204638
|
| D003042 | 1537 |
CYC1
MC3DN6 UQCR4 |
cytochrome c-1 | Cocaine results in decreased expression of CYC1 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 1558 |
CYP2C8
CPC8 CYPIIC8 MP-12/MP-20 |
cytochrome P450, family 2, subfamily C, polypeptide 8 (EC:1.14.14.1) | Cocaine results in decreased expression of CYP2C8 mRNA |
decreases expression
|
mRNA |
16188404
|
| D003042 | 1558 |
CYP2C8
CPC8 CYPIIC8 MP-12/MP-20 |
cytochrome P450, family 2, subfamily C, polypeptide 8 (EC:1.14.14.1) | Cocaine results in decreased expression of CYP2C8 protein |
decreases expression
|
protein |
16188404
|
| D003042 | 1559 |
CYP2C9
CPC9 CYP2C CYP2C10 CYPIIC9 P450IIC9 |
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) | Cocaine results in decreased expression of CYP2C9 mRNA |
decreases expression
|
mRNA |
16188404
|
| D003042 | 1559 |
CYP2C9
CPC9 CYP2C CYP2C10 CYPIIC9 P450IIC9 |
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) | Cocaine results in decreased expression of CYP2C9 protein |
decreases expression
|
protein |
16188404
|
| D003042 | 13121 | Cocaine results in decreased expression of CYP51 mRNA |
decreases expression
|
mRNA |
12629581
|
||
| D003042 | 1621 |
DBH
DBM |
dopamine beta-hydroxylase (dopamine beta-monooxygenase) (EC:1.14.17.1) | DBH gene polymorphism results in increased susceptibility to Cocaine |
increases response to substance
|
gene |
10673769
12555232 |
| D003042 | 51428 |
DDX41
ABS |
DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 (EC:3.6.4.13) | Cocaine results in decreased expression of DDX41 mRNA |
decreases expression
|
mRNA |
18000554
|
| D003042 | 10522 |
DEAF1
NUDR SPN ZMYND5 |
DEAF1 transcription factor | Cocaine results in decreased expression of DEAF1 mRNA |
decreases expression
|
mRNA |
15009677
16710320 |
| D003042 | 1769 |
DNAH8
ATPase hdhc9 |
dynein, axonemal, heavy chain 8 | DNAH8 gene SNP affects the susceptibility to Cocaine |
affects response to substance
|
gene |
18438686
|
| D003042 | 574351 | Cocaine results in decreased expression of DNCI1 mRNA |
decreases expression
|
mRNA |
12629581
|
||
| D003042 | 10591 |
DNPH1
C6orf108 RCL RP3-330M21.3 dJ330M21.3 |
2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | Cocaine results in decreased expression of DNPH1 mRNA |
decreases expression
|
mRNA |
15009677
16710320 |
| D003042 | 5977 |
DPF2
REQ UBID4 ubi-d4 |
D4, zinc and double PHD fingers family 2 | Cocaine results in increased expression of DPF2 mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 1812 |
DRD1
DADR DRD1A |
dopamine receptor D1 | 1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]] |
affects binding
/ decreases reaction / increases activity / increases phosphorylation / increases reaction |
protein |
20956312
|
| D003042 | 1812 |
DRD1
DADR DRD1A |
dopamine receptor D1 | 1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]] |
affects binding
/ decreases reaction / increases activity / increases phosphorylation / increases reaction |
protein |
20956312
|
| D003042 | 1812 |
DRD1
DADR DRD1A |
dopamine receptor D1 | Cocaine affects the localization of [DRD1 protein binds to SIGMAR1 protein] |
affects binding
/ affects localization |
protein |
20956312
|
| D003042 | 1812 |
DRD1
DADR DRD1A |
dopamine receptor D1 | [Cocaine binds to SIGMAR1 protein] affects the folding of [SIGMAR1 protein binds to DRD1 protein] |
affects binding
/ affects folding |
protein |
20956312
|
| D003042 | 1812 |
DRD1
DADR DRD1A |
dopamine receptor D1 | Cocaine promotes the reaction [DRD1 protein binds to SIGMAR1 protein] |
affects binding
/ increases reaction |
protein |
20956312
|
| D003042 | 1812 |
DRD1
DADR DRD1A |
dopamine receptor D1 | Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein] |
affects binding
/ increases activity / increases phosphorylation / increases reaction |
protein |
20956312
|
| D003042 | 1812 |
DRD1
DADR DRD1A |
dopamine receptor D1 | Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
affects binding
/ increases activity / increases phosphorylation / increases reaction |
protein |
20956312
|
| D003042 | 1812 |
DRD1
DADR DRD1A |
dopamine receptor D1 | SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]] |
affects binding
/ decreases reaction / increases activity / increases phosphorylation / increases reaction |
protein |
20956312
|
| D003042 | 1812 |
DRD1
DADR DRD1A |
dopamine receptor D1 | SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]] |
affects binding
/ decreases reaction / increases activity / increases phosphorylation / increases reaction |
protein |
20956312
|
| D003042 | 1813 |
DRD2
D2DR D2R |
dopamine receptor D2 | Cocaine affects the reaction [Raclopride binds to DRD2] |
affects binding
/ affects reaction |
15010698
|
|
| D003042 | 1813 |
DRD2
D2DR D2R |
dopamine receptor D2 | Cocaine results in decreased expression of DRD2 mRNA |
decreases expression
|
mRNA |
18000554
|
| D003042 | 1813 |
DRD2
D2DR D2R |
dopamine receptor D2 | Cocaine results in decreased expression of DRD2 protein |
decreases expression
|
protein |
9892293
11126397 19723785 |
| D003042 | 1813 |
DRD2
D2DR D2R |
dopamine receptor D2 | DRD2 polymorphism results in increased susceptibility to Cocaine |
increases response to substance
|
polymorphism |
17671965
|
| D003042 | 1814 |
DRD3
D3DR ETM1 FET1 |
dopamine receptor D3 | Cocaine results in decreased expression of DRD3 protein |
decreases expression
|
protein |
19723785
|
| D003042 | 1814 |
DRD3
D3DR ETM1 FET1 |
dopamine receptor D3 | DRD3 affects the susceptibility to Cocaine |
affects response to substance
|
10523822
|
|
| D003042 | 1815 |
DRD4
D4DR |
dopamine receptor D4 | DRD4 polymorphism results in increased susceptibility to Cocaine |
increases response to substance
|
polymorphism |
17671965
|
| D003042 | 1821 |
DRP2
|
dystrophin related protein 2 | Cocaine affects the expression of DRP2 protein |
affects expression
|
protein |
19393250
|
| D003042 | 1832 |
DSP
DP DPI DPII |
desmoplakin | Cocaine results in increased expression of DSP protein |
increases expression
|
protein |
17075605
|
| D003042 | 1906 |
EDN1
ET1 HDLCQ7 PPET1 |
endothelin 1 | Cocaine results in increased expression of EDN1 protein |
increases expression
|
protein |
9714087
11948058 18813882 |
| D003042 | 1909 |
EDNRA
ET-A ETA ETA-R ETAR ETRA hET-AR |
endothelin receptor type A | Cocaine results in increased expression of EDNRA protein |
increases expression
|
protein |
18813882
|
| D003042 | 1937 |
EEF1G
EF1G GIG35 |
eukaryotic translation elongation factor 1 gamma | Cocaine results in decreased expression of EEF1G mRNA |
decreases expression
|
mRNA |
15009677
|
| D003042 | 1956 |
EGFR
ERBB ERBB1 HER1 PIG61 mENA |
epidermal growth factor receptor (EC:2.7.10.1) | Cocaine results in decreased expression of EGFR mRNA |
decreases expression
|
mRNA |
18000554
|
| D003042 | 1984 |
EIF5A
EIF-5A EIF5A1 eIF5AI |
eukaryotic translation initiation factor 5A | Cocaine results in decreased expression of EIF5A mRNA |
decreases expression
|
mRNA |
16710320
|
| D003042 | 1984 |
EIF5A
EIF-5A EIF5A1 eIF5AI |
eukaryotic translation initiation factor 5A | Cocaine results in increased expression of EIF5A mRNA |
increases expression
|
mRNA |
15009677
|
| D003042 | 1991 |
ELANE
ELA2 GE HLE HNE NE PMN-E SCN1 |
elastase, neutrophil expressed (EC:3.4.21.37) | Cocaine affects the reaction [Antibodies, Antineutrophil Cytoplasmic binds to ELANE protein] |
affects binding
/ affects reaction |
protein |
18438818
|
| D003042 | 1991 |
ELANE
ELA2 GE HLE HNE NE PMN-E SCN1 |
elastase, neutrophil expressed (EC:3.4.21.37) | [Cocaine affects the reaction [Antibodies, Antineutrophil Cytoplasmic binds to ELANE protein]] which results in decreased activity of ELANE protein |
affects binding
/ affects reaction / decreases activity |
protein |
18438818
|
| D003042 | 375704 |
ENHO
C9orf165 UNQ470 |
energy homeostasis associated | Cocaine results in decreased expression of ENHO mRNA |
decreases expression
|
mRNA |
16710320
|
| D003042 | 2026 |
ENO2
NSE |
enolase 2 (gamma, neuronal) (EC:4.2.1.11) | Cocaine results in decreased expression of ENO2 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 2026 |
ENO2
NSE |
enolase 2 (gamma, neuronal) (EC:4.2.1.11) | Cocaine results in increased expression of ENO2 protein |
increases expression
|
protein |
17075605
|
| D003042 | 59084 |
ENPP5
|
ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) | Cocaine results in increased expression of ENPP5 mRNA |
increases expression
|
mRNA |
15009677
|
| D003042 | 2050 |
EPHB4
HTK MYK1 TYRO11 |
EPH receptor B4 (EC:2.7.10.1) | Cocaine results in decreased expression of EPHB4 mRNA |
decreases expression
|
mRNA |
18000554
|
| D003042 | 2138 |
EYA1
BOP BOR BOS1 |
eyes absent homolog 1 (Drosophila) (EC:3.1.3.16 3.1.3.48) | Cocaine results in increased expression of EYA1 mRNA |
increases expression
|
mRNA |
15009677
|
| D003042 | 7430 |
EZR
CVIL CVL VIL2 |
ezrin | Cocaine results in decreased expression of EZR mRNA |
decreases expression
|
mRNA |
20948987
|
| D003042 | 51011 |
FAHD2A
|
fumarylacetoacetate hydrolase domain containing 2A (EC:3.-.-.-) | Cocaine affects the expression of FAHD2A protein |
affects expression
|
protein |
19393250
|
| D003042 | 285596 |
FAM153A
NY-REN-7 |
family with sequence similarity 153, member A | Cocaine results in increased expression of FAM153A mRNA |
increases expression
|
mRNA |
16710320
|
| D003042 | 355 |
FAS
ALPS1A APO-1 APT1 CD95 FAS1 FASTM TNFRSF6 |
Fas cell surface death receptor | Cocaine results in increased expression of FAS mRNA |
increases expression
|
mRNA |
16710320
|
| D003042 | 2222 |
FDFT1
DGPT ERG9 SQS SS |
farnesyl-diphosphate farnesyltransferase 1 (EC:2.5.1.21) | Cocaine results in increased expression of FDFT1 mRNA |
increases expression
|
mRNA |
17205118
|
| D003042 | 2247 |
FGF2
BFGF FGF-2 FGFB HBGF-2 |
fibroblast growth factor 2 (basic) | Cocaine results in decreased expression of FGF2 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 14194 | Cocaine affects the expression of FH1 protein |
affects expression
|
protein |
19393250
|
||
| D003042 | 23767 |
FLRT3
HH21 |
fibronectin leucine rich transmembrane protein 3 | Cocaine results in increased expression of FLRT3 mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 2353 |
FOS
AP-1 C-FOS p55 |
FBJ murine osteosarcoma viral oncogene homolog | [Cocaine co-treated with SLC6A3 protein] results in increased expression of FOS protein |
affects cotreatment
/ increases expression |
protein |
12112414
|
| D003042 | 2353 |
FOS
AP-1 C-FOS p55 |
FBJ murine osteosarcoma viral oncogene homolog | Cocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA] |
affects cotreatment
/ decreases reaction / increases expression |
mRNA |
12112414
|
| D003042 | 2353 |
FOS
AP-1 C-FOS p55 |
FBJ murine osteosarcoma viral oncogene homolog | Cocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein] |
affects cotreatment
/ decreases reaction / increases expression |
protein |
12112414
|
| D003042 | 2353 |
FOS
AP-1 C-FOS p55 |
FBJ murine osteosarcoma viral oncogene homolog | Cocaine results in increased expression of FOS protein |
increases expression
|
protein |
12112414
15814102 |
| D003042 | 2354 |
FOSB
AP-1 G0S3 GOS3 GOSB |
FBJ murine osteosarcoma viral oncogene homolog B | Cocaine results in increased expression of FOSB protein |
increases expression
|
protein |
15814102
|
| D003042 | 8061 |
FOSL1
FRA FRA1 fra-1 |
FOS-like antigen 1 | Cocaine results in decreased expression of FOSL1 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 2355 |
FOSL2
FRA2 |
FOS-like antigen 2 | Cocaine promotes the reaction [JUN protein binds to FOSL2 protein] |
affects binding
/ increases reaction |
protein |
15814102
|
| D003042 | 2355 |
FOSL2
FRA2 |
FOS-like antigen 2 | Cocaine results in decreased expression of FOSL2 protein |
decreases expression
|
protein |
15814102
|
| D003042 | 2571 |
GAD1
CPSQ1 GAD SCP |
glutamate decarboxylase 1 (brain, 67kDa) (EC:4.1.1.15) | Cocaine results in decreased expression of GAD1 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 2596 |
GAP43
B-50 PP46 |
growth associated protein 43 | Cocaine results in decreased expression of GAP43 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 79571 |
GCC1
GCC1P GCC88 |
GRIP and coiled-coil domain containing 1 | Cocaine results in increased expression of GCC1 mRNA |
increases expression
|
mRNA |
17205118
|
| D003042 | 2669 |
GEM
KIR |
GTP binding protein overexpressed in skeletal muscle | Cocaine results in increased expression of GEM mRNA |
increases expression
|
mRNA |
15009677
|
| D003042 | 2670 |
GFAP
|
glial fibrillary acidic protein | Cocaine results in increased expression of GFAP protein |
increases expression
|
protein |
15814102
|
| D003042 | 2688 |
GH1
GH GH-N GHN IGHD1B hGH-N |
growth hormone 1 | Cocaine inhibits the reaction [4-hydroxybutyric acid results in increased secretion of GH1 protein] |
decreases reaction
/ increases secretion |
protein |
10657535
|
| D003042 | 2688 |
GH1
GH GH-N GHN IGHD1B hGH-N |
growth hormone 1 | Cocaine inhibits the reaction [Sodium Oxybate results in increased expression of GH1 protein] |
decreases reaction
/ increases expression |
protein |
9413023
|
| D003042 | 2706 |
GJB2
CX26 DFNA3 DFNA3A DFNB1 DFNB1A HID KID NSRD1 PPK |
gap junction protein, beta 2, 26kDa | Cocaine results in decreased expression of GJB2 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 2775 |
GNAO1
EIEE17 G-ALPHA-o GNAO |
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | Cocaine results in decreased expression of GNAO1 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 2782 |
GNB1
|
guanine nucleotide binding protein (G protein), beta polypeptide 1 | Cocaine results in decreased expression of GNB1 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 2823 |
GPM6A
GPM6 M6A |
glycoprotein M6A | Cocaine results in decreased expression of GPM6A mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 2824 |
GPM6B
M6B |
glycoprotein M6B | Cocaine results in decreased expression of GPM6B mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 2891 |
GRIA2
GLUR2 GLURB GluA2 GluR-K2 HBGR2 |
glutamate receptor, ionotropic, AMPA 2 | Cocaine results in increased expression of GRIA2 protein |
increases expression
|
protein |
16363995
|
| D003042 | 2892 |
GRIA3
GLUR-C GLUR-K3 GLUR3 GLURC GluA3 MRX94 |
glutamate receptor, ionotropic, AMPA 3 | Cocaine results in increased expression of GRIA3 protein |
increases expression
|
protein |
16363995
|
| D003042 | 2902 |
GRIN1
GluN1 MRD8 NMDA1 NMDAR1 NR1 |
glutamate receptor, ionotropic, N-methyl D-aspartate 1 | Cocaine results in increased expression of GRIN1 protein |
increases expression
|
protein |
16363995
|
| D003042 | 2934 |
GSN
ADF AGEL |
gelsolin | Cocaine results in decreased expression of GSN mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 9446 |
GSTO1
GSTO_1-1 GSTTLp28 P28 SPG-R |
glutathione S-transferase omega 1 (EC:2.5.1.18 1.8.5.1 1.20.4.2) | Cocaine affects the expression of GSTO1 protein |
affects expression
|
protein |
19393250
|
| D003042 | 2950 |
GSTP1
DFN7 FAEES3 GST3 GSTP PI |
glutathione S-transferase pi 1 (EC:2.5.1.18) | GSTP1 polymorphism affects the susceptibility to Cocaine |
affects response to substance
|
polymorphism |
16272961
|
| D003042 | 610 |
HCN2
BCNG-2 BCNG2 HAC-1 |
hyperpolarization activated cyclic nucleotide-gated potassium channel 2 | Cocaine results in increased expression of HCN2 mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 3091 |
HIF1A
HIF-1A HIF-1alpha HIF1 HIF1-ALPHA MOP1 PASD8 bHLHe78 |
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Cocaine results in decreased expression of HIF1A mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 9456 |
HOMER1
HOMER HOMER1A HOMER1B HOMER1C SYN47 Ves-1 |
homer homolog 1 (Drosophila) | HOMER1 polymorphism results in increased susceptibility to Cocaine |
increases response to substance
|
polymorphism |
16314758
|
| D003042 | 3241 |
HPCAL1
BDR1 HLP2 VILIP-3 |
hippocalcin-like 1 | Cocaine results in decreased expression of HPCAL1 mRNA |
decreases expression
|
mRNA |
15009677
|
| D003042 | 3309 |
HSPA5
BIP GRP78 MIF2 |
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Cocaine results in increased expression of HSPA5 mRNA |
increases expression
|
mRNA |
15009677
|
| D003042 | 3329 |
HSPD1
CPN60 GROEL HLD4 HSP-60 HSP60 HSP65 HuCHA60 SPG13 |
heat shock 60kDa protein 1 (chaperonin) | Cocaine affects the expression of HSPD1 protein |
affects expression
|
protein |
19393250
|
| D003042 | 3458 |
IFNG
IFG IFI |
interferon, gamma | Cocaine affects the secretion of IFNG protein |
affects secretion
|
protein |
9787120
|
| D003042 | 3458 |
IFNG
IFG IFI |
interferon, gamma | [Cocaine co-treated with Heroin] results in increased expression of IFNG protein |
affects cotreatment
/ increases expression |
protein |
16766138
|
| D003042 | 3458 |
IFNG
IFG IFI |
interferon, gamma | Cocaine results in decreased expression of IFNG protein |
decreases expression
|
protein |
9787120
|
| D003042 | 3586 |
IL10
CSIF GVHDS IL-10 IL10A TGIF |
interleukin 10 | [Cocaine co-treated with Heroin] results in increased expression of IL10 protein |
affects cotreatment
/ increases expression |
protein |
16766138
|
| D003042 | 3586 |
IL10
CSIF GVHDS IL-10 IL10A TGIF |
interleukin 10 | Cocaine results in decreased secretion of IL10 protein |
decreases secretion
|
protein |
9787120
|
| D003042 | 3586 |
IL10
CSIF GVHDS IL-10 IL10A TGIF |
interleukin 10 | Cocaine results in increased expression of IL10 protein |
increases expression
|
protein |
9787120
|
| D003042 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | Cocaine results in increased expression of IL1B mRNA |
increases expression
|
mRNA |
20948987
|
| D003042 | 3558 |
IL2
IL-2 TCGF lymphokine |
interleukin 2 | [Cocaine co-treated with Heroin] results in increased expression of IL2 protein |
affects cotreatment
/ increases expression |
protein |
16766138
|
| D003042 | 3565 |
IL4
BCGF-1 BCGF1 BSF-1 BSF1 IL-4 |
interleukin 4 | [Cocaine co-treated with Heroin] results in increased expression of IL4 protein |
affects cotreatment
/ increases expression |
protein |
16766138
|
| D003042 | 3569 |
IL6
BSF2 HGF HSF IFNB2 IL-6 |
interleukin 6 (interferon, beta 2) | Cocaine results in decreased expression of IL6 protein |
decreases expression
|
protein |
17068203
|
| D003042 | 3576 |
IL8
CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
interleukin 8 | Cocaine results in increased secretion of IL8 protein |
increases secretion
|
protein |
10065903
|
| D003042 | 3623 |
INHA
|
inhibin, alpha | Cocaine results in decreased expression of INHA mRNA |
decreases expression
|
mRNA |
18000554
|
| D003042 | 3630 |
INS
IDDM2 ILPR IRDN MODY10 |
insulin | Cocaine results in decreased expression of INS protein |
decreases expression
|
protein |
18346162
|
| D003042 | 10379 |
IRF9
IRF-9 ISGF3 ISGF3G p48 |
interferon regulatory factor 9 | Cocaine results in decreased expression of IRF9 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 9270 |
ITGB1BP1
ICAP-1A ICAP-1B ICAP-1alpha ICAP1 ICAP1A ICAP1B |
integrin beta 1 binding protein 1 | Cocaine results in increased expression of ITGB1BP1 mRNA |
increases expression
|
mRNA |
15009677
16710320 |
| D003042 | 3694 |
ITGB6
|
integrin, beta 6 | Cocaine results in increased expression of ITGB6 mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 3725 |
JUN
AP-1 AP1 c-Jun |
jun proto-oncogene | Cocaine promotes the reaction [JUN protein binds to FOSL2 protein] |
affects binding
/ increases reaction |
protein |
15814102
|
| D003042 | 3725 |
JUN
AP-1 AP1 c-Jun |
jun proto-oncogene | Cocaine results in increased expression of JUN protein |
increases expression
|
protein |
15814102
|
| D003042 | 3726 |
JUNB
AP-1 |
jun B proto-oncogene | Cocaine affects the expression of JUNB protein |
affects expression
|
protein |
15814102
|
| D003042 | 3727 |
JUND
AP-1 |
jun D proto-oncogene | Cocaine results in decreased expression of JUND protein |
decreases expression
|
protein |
15814102
|
| D003042 | 3763 |
KCNJ6
BIR1 GIRK-2 GIRK2 KATP-2 KATP2 KCNJ7 KIR3.2 hiGIRK2 |
potassium inwardly-rectifying channel, subfamily J, member 6 | Cocaine results in decreased expression of KCNJ6 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 9365 |
KL
|
klotho (EC:3.2.1.31) | Cocaine results in increased expression of KL mRNA |
increases expression
|
mRNA |
15009677
|
| D003042 | 51088 |
KLHL5
|
kelch-like family member 5 | KLHL5 gene SNP affects the susceptibility to Cocaine |
affects response to substance
|
gene |
18438686
|
| D003042 | 889 |
KRIT1
CAM CCM1 |
KRIT1, ankyrin repeat containing | Cocaine results in increased expression of KRIT1 mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 3912 |
LAMB1
CLM LIS5 |
laminin, beta 1 | Cocaine results in increased expression of LAMB1 mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 470879 | Cocaine results in decreased expression of LAMR1 mRNA |
decreases expression
|
mRNA |
12629581
|
||
| D003042 | 9079 |
LDB2
CLIM1 LDB1 |
LIM domain binding 2 | Cocaine results in decreased expression of LDB2 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 55327 |
LIN7C
LIN-7-C LIN-7C MALS-3 MALS3 VELI3 |
lin-7 homolog C (C. elegans) | Cocaine results in increased expression of LIN7C mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 1902 |
LPAR1
EDG2 GPR26 Gpcr26 LPA1 Mrec1.3 VZG1 edg-2 rec.1.3 vzg-1 |
lysophosphatidic acid receptor 1 | Cocaine results in decreased expression of LPAR1 mRNA |
decreases expression
|
mRNA |
15009677
|
| D003042 | 57554 |
LRRC7
DENSIN |
leucine rich repeat containing 7 | LRRC7 gene SNP affects the susceptibility to Cocaine |
affects response to substance
|
gene |
18438686
|
| D003042 | 114569 |
MAL2
|
mal, T-cell differentiation protein 2 (gene/pseudogene) | Cocaine results in increased expression of MAL2 mRNA |
increases expression
|
mRNA |
15009677
|
| D003042 | 37838 | Cocaine results in increased expression of MAN1 mRNA |
increases expression
|
mRNA |
18000554
|
||
| D003042 | 79694 |
MANEA
ENDO hEndo |
mannosidase, endo-alpha (EC:3.2.1.130) | MANEA gene SNP affects the susceptibility to Cocaine |
affects response to substance
|
gene |
18438686
|
| D003042 | 4131 |
MAP1B
FUTSCH MAP5 |
microtubule-associated protein 1B | Cocaine results in decreased expression of MAP1B mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 5604 |
MAP2K1
CFC3 MAPKK1 MEK1 MKK1 PRKMK1 |
mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) | Cocaine results in decreased expression of MAP2K1 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | 1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]] |
affects binding
/ decreases reaction / increases activity / increases phosphorylation / increases reaction |
protein |
20956312
|
| D003042 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein] |
affects binding
/ increases activity / increases phosphorylation / increases reaction |
protein |
20956312
|
| D003042 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]] |
affects binding
/ decreases reaction / increases activity / increases phosphorylation / increases reaction |
protein |
20956312
|
| D003042 | 5602 |
MAPK10
JNK3 JNK3A PRKM10 SAPK1b p493F12 p54bSAPK |
mitogen-activated protein kinase 10 (EC:2.7.11.24) | Cocaine results in decreased expression of MAPK10 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | 1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]] |
affects binding
/ decreases reaction / increases activity / increases phosphorylation / increases reaction |
protein |
20956312
|
| D003042 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
affects binding
/ increases activity / increases phosphorylation / increases reaction |
protein |
20956312
|
| D003042 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | Cocaine results in increased expression of MAPK3 mRNA |
increases expression
|
mRNA |
12629581
|
| D003042 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]] |
affects binding
/ decreases reaction / increases activity / increases phosphorylation / increases reaction |
protein |
20956312
|
| D003042 | 64844 |
MARCH7
AXO AXOT MARCH-VII RNF177 |
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase | Cocaine results in increased expression of MARCH7 mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 4155 |
MBP
|
myelin basic protein | Cocaine results in decreased expression of MBP mRNA |
decreases expression
|
mRNA |
15009677
|
| D003042 | 4155 |
MBP
|
myelin basic protein | Cocaine results in decreased expression of MBP protein |
decreases expression
|
protein |
15009677
|
| D003042 | 4190 |
MDH1
MDH-s MDHA MGC:1375 MOR2 |
malate dehydrogenase 1, NAD (soluble) (EC:1.1.1.37 1.1.1.96) | Cocaine results in decreased expression of MDH1 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 4204 |
MECP2
AUTSX3 MRX16 MRX79 MRXS13 MRXSL PPMX RS RTS RTT |
methyl CpG binding protein 2 (Rett syndrome) | MECP2 mRNA inhibits the reaction [Cocaine results in increased expression of MIR132 protein] |
decreases reaction
/ increases expression |
mRNA |
20711185
|
| D003042 | 4204 |
MECP2
AUTSX3 MRX16 MRX79 MRXS13 MRXSL PPMX RS RTS RTT |
methyl CpG binding protein 2 (Rett syndrome) | MECP2 mRNA inhibits the reaction [Cocaine results in increased expression of MIR212 protein] |
decreases reaction
/ increases expression |
mRNA |
20711185
|
| D003042 | 4209 |
MEF2D
|
myocyte enhancer factor 2D | Cocaine results in decreased expression of MEF2D mRNA |
decreases expression
|
mRNA |
18000554
|
| D003042 | 406921 |
MIR132
MIRN132 miRNA132 |
microRNA 132 | MECP2 mRNA inhibits the reaction [Cocaine results in increased expression of MIR132 protein] |
decreases reaction
/ increases expression |
protein |
20711185
|
| D003042 | 406994 |
MIR212
MIRN212 mir-212 |
microRNA 212 | MECP2 mRNA inhibits the reaction [Cocaine results in increased expression of MIR212 protein] |
decreases reaction
/ increases expression |
protein |
20711185
|
| D003042 | 4318 |
MMP9
CLG4B GELB MANDP2 MMP-9 |
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) | Cocaine results in decreased expression of and results in decreased activity of MMP9 protein |
decreases activity
/ decreases expression |
protein |
18000554
|
| D003042 | 39610 | Cocaine results in decreased expression of MOP mRNA |
decreases expression
|
mRNA |
15009677
|
||
| D003042 | 79664 |
NARG2
BRCC1 |
NMDA receptor regulated 2 | NARG2 gene SNP affects the susceptibility to Cocaine |
affects response to substance
|
gene |
18438686
|
| D003042 | 57447 |
NDRG2
SYLD |
NDRG family member 2 | Cocaine results in decreased expression of NDRG2 mRNA |
decreases expression
|
mRNA |
15009677
|
| D003042 | 4705 |
NDUFA10
CI-42KD CI-42k |
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa (EC:1.6.5.3 1.6.99.3) | Cocaine affects the expression of NDUFA10 protein |
affects expression
|
protein |
19393250
|
| D003042 | 4720 |
NDUFS2
CI-49 |
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) (EC:1.6.5.3 1.6.99.3) | Cocaine affects the expression of NDUFS2 protein |
affects expression
|
protein |
19393250
|
| D003042 | 23327 |
NEDD4L
NEDD4-2 NEDD4.2 RSP5 hNEDD4-2 |
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase (EC:6.3.2.-) | Cocaine results in increased expression of NEDD4L mRNA |
increases expression
|
mRNA |
15009677
|
| D003042 | 4747 |
NEFL
CMT1F CMT2E NF-L NF68 NFL |
neurofilament, light polypeptide | Cocaine results in decreased expression of NEFL mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 4741 |
NEFM
NEF3 NF-M NFM |
neurofilament, medium polypeptide | Cocaine results in decreased expression of NEFM mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 81831 |
NETO2
BTCL2 NEOT2 |
neuropilin (NRP) and tolloid (TLL)-like 2 | Cocaine results in increased expression of NETO2 mRNA |
increases expression
|
mRNA |
15009677
|
| D003042 | 4779 |
NFE2L1
LCR-F1 NRF1 TCF11 |
nuclear factor, erythroid 2-like 1 | Cocaine results in increased expression of NFE2L1 mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 4801 |
NFYB
CBF-A CBF-B HAP3 NF-YB |
nuclear transcription factor Y, beta | Cocaine results in increased expression of NFYB mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 4803 |
NGF
Beta-NGF HSAN5 NGFB |
nerve growth factor (beta polypeptide) | Cocaine results in decreased expression of NGF protein |
decreases expression
|
protein |
17715210
|
| D003042 | 4831 |
NME2
NDKB NDPK-B NDPKB NM23-H2 NM23B PUF |
NME/NM23 nucleoside diphosphate kinase 2 (EC:2.7.4.6 2.7.13.3) | Cocaine affects the expression of NME2 protein |
affects expression
|
protein |
19393250
|
| D003042 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | Cocaine results in decreased expression of NOS3 protein |
decreases expression
|
protein |
18813882
|
| D003042 | 23117 |
NPIPB3
KIAA0220L NPIPB5 NPIPL3 |
nuclear pore complex interacting protein family, member B3 | Cocaine results in increased expression of NPIPB3 mRNA |
increases expression
|
mRNA |
16710320
|
| D003042 | 4878 |
NPPA
ANF ANP ATFB6 CDD-ANF PND |
natriuretic peptide A | Cocaine results in increased expression of NPPA protein |
increases expression
|
protein |
11377647
|
| D003042 | 9970 |
NR1I3
CAR CAR1 MB67 |
nuclear receptor subfamily 1, group I, member 3 | Cocaine results in decreased expression of NR1I3 mRNA |
decreases expression
|
mRNA |
16188404
|
| D003042 | 2908 |
NR3C1
GCCR GCR GR GRL |
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | Cocaine results in decreased expression of NR3C1 mRNA |
decreases expression
|
mRNA |
16188404
20948987 |
| D003042 | 4929 |
NR4A2
HZF-3 NOT NURR1 RNR1 TINUR |
nuclear receptor subfamily 4, group A, member 2 | Cocaine results in decreased expression of NR4A2 protein |
decreases expression
|
protein |
15094491
|
| D003042 | 4905 |
NSF
SKD2 |
N-ethylmaleimide-sensitive factor (EC:3.6.4.6) | Cocaine results in decreased expression of NSF mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 4915 |
NTRK2
GP145-TrkB TRKB trk-B |
neurotrophic tyrosine kinase, receptor, type 2 (EC:2.7.10.1) | Cocaine results in decreased expression of NTRK2 mRNA |
decreases expression
|
mRNA |
15009677
16710320 |
| D003042 | 64710 |
NUCKS1
NUCKS |
nuclear casein kinase and cyclin-dependent kinase substrate 1 | Cocaine results in decreased expression of NUCKS1 mRNA |
decreases expression
|
mRNA |
15009677
16710320 |
| D003042 | 4983 |
OPHN1
ARHGAP41 MRX60 OPN1 |
oligophrenin 1 | Cocaine results in increased expression of OPHN1 mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 4988 |
OPRM1
LMOR M-OR-1 MOP MOR MOR1 OPRM |
opioid receptor, mu 1 | Cocaine affects the reaction [carfentanil binds to OPRM1 protein] |
affects binding
/ affects reaction |
protein |
15953495
|
| D003042 | 4988 |
OPRM1
LMOR M-OR-1 MOP MOR MOR1 OPRM |
opioid receptor, mu 1 | OPRM1 gene SNP results in increased susceptibility to Cocaine |
increases response to substance
|
gene |
12815747
|
| D003042 | 114876 |
OSBPL1A
ORP-1 ORP1 OSBPL1B |
oxysterol binding protein-like 1A | Cocaine results in decreased expression of OSBPL1A mRNA |
decreases expression
|
mRNA |
15009677
|
| D003042 | 56924 |
PAK6
PAK5 |
p21 protein (Cdc42/Rac)-activated kinase 6 (EC:2.7.11.1) | Cocaine results in decreased expression of PAK6 mRNA |
decreases expression
|
mRNA |
18000554
|
| D003042 | 7849 |
PAX8
|
paired box 8 | Cocaine results in increased expression of PAX8 mRNA |
increases expression
|
mRNA |
12629581
|
| D003042 | 5100 |
PCDH8
ARCADLIN PAPC |
protocadherin 8 | Cocaine results in increased expression of PCDH8 mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 5100 |
PCDH8
ARCADLIN PAPC |
protocadherin 8 | Cocaine results in increased expression of PCDH8 protein |
increases expression
|
protein |
18000554
|
| D003042 | 56146 |
PCDHA2
PCDH-ALPHA2 |
protocadherin alpha 2 | Cocaine results in increased expression of PCDHA2 mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 56114 |
PCDHGA1
PCDH-GAMMA-A1 |
protocadherin gamma subfamily A, 1 | Cocaine results in increased expression of PCDHGA1 mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 27344 |
PCSK1N
PROSAAS SAAS |
proprotein convertase subtilisin/kexin type 1 inhibitor | Cocaine results in decreased expression of PCSK1N mRNA |
decreases expression
|
mRNA |
15009677
|
| D003042 | 5126 |
PCSK2
NEC_2 NEC-2 NEC2 PC2 SPC2 |
proprotein convertase subtilisin/kexin type 2 (EC:3.4.21.94) | Cocaine results in decreased expression of PCSK2 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 10081 |
PDCD7
ES18 HES18 |
programmed cell death 7 | Cocaine results in increased expression of PDCD7 mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 9659 |
PDE4DIP
CMYA2 MMGL |
phosphodiesterase 4D interacting protein | Cocaine results in decreased expression of PDE4DIP mRNA |
decreases expression
|
mRNA |
16710320
|
| D003042 | 5173 |
PDYN
ADCA PENKB SCA23 |
prodynorphin | Cocaine results in increased expression of PDYN mRNA |
increases expression
|
mRNA |
15009677
16710320 |
| D003042 | 5173 |
PDYN
ADCA PENKB SCA23 |
prodynorphin | Cocaine results in increased expression of PDYN protein |
increases expression
|
protein |
18538358
|
| D003042 | 5173 |
PDYN
ADCA PENKB SCA23 |
prodynorphin | PDYN gene SNP affects the susceptibility to Cocaine |
affects response to substance
|
gene |
18923396
|
| D003042 | 5173 |
PDYN
ADCA PENKB SCA23 |
prodynorphin | PDYN promoter polymorphism results in decreased susceptibility to Cocaine |
decreases response to substance
|
promoter |
11992566
|
| D003042 | 5173 |
PDYN
ADCA PENKB SCA23 |
prodynorphin | PDYN promoter polymorphism results in increased susceptibility to Cocaine |
increases response to substance
|
promoter |
16184603
|
| D003042 | 5037 |
PEBP1
HCNP HCNPpp PBP PEBP PEBP-1 RKIP |
phosphatidylethanolamine binding protein 1 | Cocaine affects the expression of PEBP1 protein |
affects expression
|
protein |
19393250
|
| D003042 | 5179 |
PENK
|
proenkephalin | Cocaine results in decreased expression of PENK mRNA |
decreases expression
|
mRNA |
15814102
|
| D003042 | 5196 |
PF4
CXCL4 PF-4 SCYB4 |
platelet factor 4 | Cocaine results in increased expression of PF4 protein |
increases expression
|
protein |
10814631
|
| D003042 | 5216 |
PFN1
ALS18 |
profilin 1 | Cocaine results in increased expression of PFN1 mRNA |
increases expression
|
mRNA |
12629581
|
| D003042 | 5292 |
PIM1
PIM |
pim-1 oncogene (EC:2.7.11.1) | Cocaine results in decreased expression of PIM1 mRNA |
decreases expression
|
mRNA |
18000554
|
| D003042 | 5309 |
PITX3
ASMD CTPP4 CTRCT11 PTX3 |
paired-like homeodomain 3 | Cocaine results in decreased expression of PITX3 protein |
decreases expression
|
protein |
15094491
|
| D003042 | 5354 |
PLP1
GPM6C HLD1 MMPL PLP PLP/DM20 PMD SPG2 |
proteolipid protein 1 | Cocaine affects the expression of PLP1 mRNA |
affects expression
|
mRNA |
18357522
|
| D003042 | 5354 |
PLP1
GPM6C HLD1 MMPL PLP PLP/DM20 PMD SPG2 |
proteolipid protein 1 | Cocaine results in decreased expression of PLP1 mRNA |
decreases expression
|
mRNA |
12629581
15009677 |
| D003042 | 56937 |
PMEPA1
STAG1 TMEPAI |
prostate transmembrane protein, androgen induced 1 | Cocaine results in increased expression of PMEPA1 mRNA |
increases expression
|
mRNA |
15009677
16710320 |
| D003042 | 5443 |
POMC
ACTH CLIP LPH MSH NPP POC |
proopiomelanocortin | Cocaine results in increased secretion of POMC protein |
increases secretion
|
protein |
11750770
|
| D003042 | 8612 |
PPAP2C
LPP2 PAP-2c PAP2-g |
phosphatidic acid phosphatase type 2C (EC:3.1.3.4) | Cocaine results in decreased expression of PPAP2C mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 5473 |
PPBP
B-TG1 Beta-TG CTAP-III CTAP3 CTAPIII CXCL7 LA-PF4 LDGF MDGF NAP-2 PBP SCYB7 TC1 TC2 TGB TGB1 THBGB THBGB1 |
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | Cocaine results in increased expression of PPBP protein |
increases expression
|
protein |
10814631
|
| D003042 | 8541 |
PPFIA3
LPNA3 |
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 | Cocaine results in increased expression of PPFIA3 protein |
increases expression
|
protein |
17075605
|
| D003042 | 8496 |
PPFIBP1
L2 SGT2 hSGT2 hSgt2p |
PTPRF interacting protein, binding protein 1 (liprin beta 1) | Cocaine results in increased expression of PPFIBP1 mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 5481 |
PPID
CYP-40 CYPD |
peptidylprolyl isomerase D (EC:5.2.1.8) | Cocaine results in increased expression of PPID mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 5499 |
PPP1CA
PP-1A PP1A PP1alpha PPP1A |
protein phosphatase 1, catalytic subunit, alpha isozyme (EC:3.1.3.16) | Cocaine results in decreased expression of PPP1CA mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 5515 |
PPP2CA
PP2Ac PP2CA PP2Calpha RP-C |
protein phosphatase 2, catalytic subunit, alpha isozyme (EC:3.1.3.16) | Cocaine results in decreased expression of PPP2CA mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 5516 |
PPP2CB
PP2Abeta PP2CB |
protein phosphatase 2, catalytic subunit, beta isozyme (EC:3.1.3.16) | Cocaine results in decreased expression of PPP2CB mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 5522 |
PPP2R2C
B55-GAMMA IMYPNO IMYPNO1 PR52 PR55G |
protein phosphatase 2, regulatory subunit B, gamma (EC:3.1.3.16) | Cocaine results in decreased expression of PPP2R2C mRNA |
decreases expression
|
mRNA |
15009677
|
| D003042 | 7001 |
PRDX2
NKEF-B NKEFB PRP PRX2 PRXII PTX1 TDPX1 TPX1 TSA |
peroxiredoxin 2 (EC:1.11.1.15) | Cocaine affects the expression of PRDX2 protein |
affects expression
|
protein |
19393250
|
| D003042 | 7001 |
PRDX2
NKEF-B NKEFB PRP PRX2 PRXII PTX1 TDPX1 TPX1 TSA |
peroxiredoxin 2 (EC:1.11.1.15) | Cocaine results in decreased expression of PRDX2 protein |
decreases expression
|
protein |
17075605
|
| D003042 | 25824 |
PRDX5
ACR1 AOEB166 B166 PLP PMP20 PRDX6 PRXV prx-V |
peroxiredoxin 5 (EC:1.11.1.15) | Cocaine affects the expression of PRDX5 protein |
affects expression
|
protein |
19393250
|
| D003042 | 9581 |
PREPL
|
prolyl endopeptidase-like (EC:3.4.21.-) | Cocaine results in increased expression of PREPL mRNA |
increases expression
|
mRNA |
16710320
|
| D003042 | 5579 |
PRKCB
PKC-beta PKCB PRKCB1 PRKCB2 |
protein kinase C, beta (EC:2.7.11.13) | Cocaine results in decreased expression of PRKCB mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 5617 |
PRL
|
prolactin | Cocaine affects the expression of PRL protein |
affects expression
|
protein |
14512708
|
| D003042 | 5617 |
PRL
|
prolactin | Cocaine affects the reaction [Fenfluramine results in increased expression of PRL protein] |
affects reaction
/ increases expression |
protein |
10349036
|
| D003042 | 5617 |
PRL
|
prolactin | Cocaine affects the secretion of PRL protein |
affects secretion
|
protein |
2584360
|
| D003042 | 5617 |
PRL
|
prolactin | Cocaine inhibits the reaction [1-(3-chlorophenyl)piperazine results in increased expression of PRL protein] |
decreases reaction
/ increases expression |
protein |
16418827
|
| D003042 | 5617 |
PRL
|
prolactin | Cocaine results in decreased expression of PRL protein |
decreases expression
|
protein |
15833589
|
| D003042 | 5617 |
PRL
|
prolactin | Cocaine results in decreased secretion of PRL protein |
decreases secretion
|
protein |
17000009
|
| D003042 | 5617 |
PRL
|
prolactin | Cocaine results in increased expression of PRL protein |
increases expression
|
protein |
15064918
|
| D003042 | 5657 |
PRTN3
ACPA AGP7 C-ANCA CANCA MBN MBT NP-4 NP4 P29 PR-3 PR3 |
proteinase 3 (EC:3.4.21.76) | Cocaine affects the reaction [Antibodies, Antineutrophil Cytoplasmic binds to PRTN3 protein] |
affects binding
/ affects reaction |
protein |
18438818
|
| D003042 | 23198 |
PSME4
PA200 |
proteasome (prosome, macropain) activator subunit 4 | Cocaine results in increased expression of PSME4 mRNA |
increases expression
|
mRNA |
15009677
|
| D003042 | 5747 |
PTK2
FADK FAK FAK1 FRNK PPP1R71 p125FAK pp125FAK |
protein tyrosine kinase 2 (EC:2.7.10.2) | Cocaine results in decreased expression of PTK2 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 5764 |
PTN
HARP HBGF8 HBNF NEGF1 |
pleiotrophin | Cocaine results in decreased expression of PTN mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 5786 |
PTPRA
HEPTP HLPR HPTPA HPTPalpha LRP PTPA PTPRL2 R-PTP-alpha RPTPA |
protein tyrosine phosphatase, receptor type, A (EC:3.1.3.48) | Cocaine results in decreased expression of PTPRA mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 5787 |
PTPRB
HPTP-BETA HPTPB PTPB R-PTP-BETA VEPTP |
protein tyrosine phosphatase, receptor type, B (EC:3.1.3.48) | Cocaine results in decreased expression of PTPRB mRNA |
decreases expression
|
mRNA |
18000554
|
| D003042 | 5816 |
PVALB
D22S749 |
parvalbumin | Cocaine results in decreased expression of PVALB protein |
decreases expression
|
protein |
17075605
|
| D003042 | 8434 |
RECK
ST15 |
reversion-inducing-cysteine-rich protein with kazal motifs | Cocaine results in increased expression of RECK protein |
increases expression
|
protein |
18000554
|
| D003042 | 6204 |
RPS10
DBA9 S10 |
ribosomal protein S10 | Cocaine results in decreased expression of RPS10 mRNA |
decreases expression
|
mRNA |
15009677
|
| D003042 | 6203 |
RPS9
S9 |
ribosomal protein S9 | Cocaine results in decreased expression of RPS9 mRNA |
decreases expression
|
mRNA |
15009677
|
| D003042 | 23429 |
RYBP
AAP1 DEDAF YEAF1 |
RING1 and YY1 binding protein | Cocaine results in increased expression of RYBP mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 949 |
SCARB1
CD36L1 CLA-1 CLA1 HDLQTL6 SR-BI SRB1 |
scavenger receptor class B, member 1 | Cocaine results in increased expression of SCARB1 mRNA |
increases expression
|
mRNA |
17205118
|
| D003042 | 6403 |
SELP
CD62 CD62P GMP140 GRMP LECAM3 PADGEM PSEL |
selectin P (granule membrane protein 140kDa, antigen CD62) | Cocaine affects the localization of SELP protein |
affects localization
|
protein |
7689042
10814631 |
| D003042 | 7869 |
SEMA3B
LUCA-1 SEMA5 SEMAA SemA semaV |
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | Cocaine results in increased expression of SEMA3B mRNA |
increases expression
|
mRNA |
17205118
|
| D003042 | 57556 |
SEMA6A
HT018 SEMA SEMA6A1 SEMAQ VIA |
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | Cocaine results in decreased expression of SEMA6A mRNA |
decreases expression
|
mRNA |
18000554
|
| D003042 | 5414 |
SEPT4
ARTS BRADEION CE5B3 H5 MART PNUTL2 SEP4 hCDCREL-2 |
septin 4 | Cocaine results in decreased expression of SEPT4 mRNA |
decreases expression
|
mRNA |
12629581
15009677 16710320 |
| D003042 | 6443 |
SGCB
A3b LGMD2E SGC |
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) | Cocaine results in decreased expression of SGCB mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 6443 |
SGCB
A3b LGMD2E SGC |
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) | Cocaine results in increased expression of SGCB mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 23678 |
SGK3
CISK SGK2 SGKL |
serum/glucocorticoid regulated kinase family, member 3 (EC:2.7.11.1) | Cocaine results in increased expression of SGK3 mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 22941 |
SHANK2
AUTS17 CORTBP1 CTTNBP1 ProSAP1 SHANK SPANK-3 |
SH3 and multiple ankyrin repeat domains 2 | Cocaine results in decreased expression of SHANK2 mRNA |
decreases expression
|
mRNA |
18000554
|
| D003042 | 10280 |
SIGMAR1
ALS16 OPRS1 SIG-1R SR-BP SR-BP1 SRBP hSigmaR1 sigma1R |
sigma non-opioid intracellular receptor 1 | 1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]] |
affects binding
/ decreases reaction / increases activity / increases phosphorylation / increases reaction |
protein |
20956312
|
| D003042 | 10280 |
SIGMAR1
ALS16 OPRS1 SIG-1R SR-BP SR-BP1 SRBP hSigmaR1 sigma1R |
sigma non-opioid intracellular receptor 1 | 1-propyl-5-(3-p-tolylisoxazol-5-yl)-1,2,3,6-tetrahydropyridine inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]] |
affects binding
/ decreases reaction / increases activity / increases phosphorylation / increases reaction |
protein |
20956312
|
| D003042 | 10280 |
SIGMAR1
ALS16 OPRS1 SIG-1R SR-BP SR-BP1 SRBP hSigmaR1 sigma1R |
sigma non-opioid intracellular receptor 1 | Cocaine affects the localization of [DRD1 protein binds to SIGMAR1 protein] |
affects binding
/ affects localization |
protein |
20956312
|
| D003042 | 10280 |
SIGMAR1
ALS16 OPRS1 SIG-1R SR-BP SR-BP1 SRBP hSigmaR1 sigma1R |
sigma non-opioid intracellular receptor 1 | Cocaine binds to SIGMAR1 protein |
affects binding
|
protein |
20956312
|
| D003042 | 10280 |
SIGMAR1
ALS16 OPRS1 SIG-1R SR-BP SR-BP1 SRBP hSigmaR1 sigma1R |
sigma non-opioid intracellular receptor 1 | [Cocaine binds to SIGMAR1 protein] affects the folding of [SIGMAR1 protein binds to DRD1 protein] |
affects binding
/ affects folding |
protein |
20956312
|
| D003042 | 10280 |
SIGMAR1
ALS16 OPRS1 SIG-1R SR-BP SR-BP1 SRBP hSigmaR1 sigma1R |
sigma non-opioid intracellular receptor 1 | Cocaine promotes the reaction [DRD1 protein binds to SIGMAR1 protein] |
affects binding
/ increases reaction |
protein |
20956312
|
| D003042 | 10280 |
SIGMAR1
ALS16 OPRS1 SIG-1R SR-BP SR-BP1 SRBP hSigmaR1 sigma1R |
sigma non-opioid intracellular receptor 1 | Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein] |
affects binding
/ increases activity / increases phosphorylation / increases reaction |
protein |
20956312
|
| D003042 | 10280 |
SIGMAR1
ALS16 OPRS1 SIG-1R SR-BP SR-BP1 SRBP hSigmaR1 sigma1R |
sigma non-opioid intracellular receptor 1 | Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein] |
affects binding
/ increases activity / increases phosphorylation / increases reaction |
protein |
20956312
|
| D003042 | 10280 |
SIGMAR1
ALS16 OPRS1 SIG-1R SR-BP SR-BP1 SRBP hSigmaR1 sigma1R |
sigma non-opioid intracellular receptor 1 | SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]] |
affects binding
/ decreases reaction / increases activity / increases phosphorylation / increases reaction |
protein |
20956312
|
| D003042 | 10280 |
SIGMAR1
ALS16 OPRS1 SIG-1R SR-BP SR-BP1 SRBP hSigmaR1 sigma1R |
sigma non-opioid intracellular receptor 1 | SCH 23390 inhibits the reaction [Cocaine promotes the reaction [[SIGMAR1 protein binds to DRD1 protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]] |
affects binding
/ decreases reaction / increases activity / increases phosphorylation / increases reaction |
protein |
20956312
|
| D003042 | 6554 |
SLC10A1
NTCP |
solute carrier family 10 (sodium/bile acid cotransporter), member 1 | Cocaine results in increased expression of SLC10A1 mRNA |
increases expression
|
mRNA |
12629581
|
| D003042 | 6571 |
SLC18A2
SVAT SVMT VAT2 VMAT2 |
solute carrier family 18 (vesicular monoamine transporter), member 2 | Cocaine results in decreased expression of SLC18A2 protein |
decreases expression
|
protein |
12505801
|
| D003042 | 9389 |
SLC22A14
OCTL2 OCTL4 ORCTL4 |
solute carrier family 22, member 14 | Cocaine results in decreased expression of SLC22A14 mRNA |
decreases expression
|
mRNA |
18000554
|
| D003042 | 79085 |
SLC25A23
APC2 MCSC2 SCaMC-3 |
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23 | Cocaine results in decreased expression of SLC25A23 mRNA |
decreases expression
|
mRNA |
16710320
|
| D003042 | 51312 |
SLC25A37
MFRN MFRN1 MSC MSCP PRO1278 PRO1584 PRO2217 |
solute carrier family 25 (mitochondrial iron transporter), member 37 | Cocaine results in increased expression of SLC25A37 mRNA |
increases expression
|
mRNA |
15009677
16710320 |
| D003042 | 23443 |
SLC35A3
|
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | Cocaine results in increased expression of SLC35A3 mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 6530 |
SLC6A2
NAT1 NET NET1 SLC6A5 |
solute carrier family 6 (neurotransmitter transporter), member 2 | Cocaine results in decreased activity of SLC6A2 protein |
decreases activity
|
protein |
11082428
|
| D003042 | 6530 |
SLC6A2
NAT1 NET NET1 SLC6A5 |
solute carrier family 6 (neurotransmitter transporter), member 2 | Cocaine results in increased expression of SLC6A2 protein |
increases expression
|
protein |
15763139
19728366 |
| D003042 | 6531 |
SLC6A3
DAT DAT1 PKDYS |
solute carrier family 6 (neurotransmitter transporter), member 3 | Butyrates inhibits the reaction [Cocaine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]] |
decreases reaction
/ increases uptake |
protein |
17250655
|
| D003042 | 6531 |
SLC6A3
DAT DAT1 PKDYS |
solute carrier family 6 (neurotransmitter transporter), member 3 | Cocaine binds to SLC6A3 protein |
affects binding
|
protein |
9372557
|
| D003042 | 6531 |
SLC6A3
DAT DAT1 PKDYS |
solute carrier family 6 (neurotransmitter transporter), member 3 | [Cocaine co-treated with SLC6A3 protein] results in increased expression of FOS protein |
affects cotreatment
/ increases expression |
protein |
12112414
|
| D003042 | 6531 |
SLC6A3
DAT DAT1 PKDYS |
solute carrier family 6 (neurotransmitter transporter), member 3 | Cocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA] |
affects cotreatment
/ decreases reaction / increases expression |
protein |
12112414
|
| D003042 | 6531 |
SLC6A3
DAT DAT1 PKDYS |
solute carrier family 6 (neurotransmitter transporter), member 3 | Cocaine inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein] |
affects cotreatment
/ decreases reaction / increases expression |
protein |
12112414
|
| D003042 | 6531 |
SLC6A3
DAT DAT1 PKDYS |
solute carrier family 6 (neurotransmitter transporter), member 3 | Cocaine inhibits the reaction [Melitten results in increased localization of SLC6A3 protein] |
decreases reaction
/ increases localization |
protein |
20969853
22683840 |
| D003042 | 6531 |
SLC6A3
DAT DAT1 PKDYS |
solute carrier family 6 (neurotransmitter transporter), member 3 | Cocaine inhibits the reaction [SLC6A3 protein results in increased transport of phenethylamine] |
decreases reaction
/ increases transport |
protein |
15764732
|
| D003042 | 6531 |
SLC6A3
DAT DAT1 PKDYS |
solute carrier family 6 (neurotransmitter transporter), member 3 | Cocaine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine] |
decreases reaction
/ increases uptake |
protein |
17250655
|
| D003042 | 6531 |
SLC6A3
DAT DAT1 PKDYS |
solute carrier family 6 (neurotransmitter transporter), member 3 | Cocaine promotes the reaction [(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester binds to SLC6A3 protein] |
affects binding
/ increases reaction |
protein |
12064476
16110277 |
| D003042 | 6531 |
SLC6A3
DAT DAT1 PKDYS |
solute carrier family 6 (neurotransmitter transporter), member 3 | Cocaine results in decreased expression of SLC6A3 mRNA |
decreases expression
|
mRNA |
9736005
10581411 11165777 |
| D003042 | 6531 |
SLC6A3
DAT DAT1 PKDYS |
solute carrier family 6 (neurotransmitter transporter), member 3 | Cocaine results in increased expression of SLC6A3 protein |
increases expression
|
protein |
16110277
18565692 |
| D003042 | 6531 |
SLC6A3
DAT DAT1 PKDYS |
solute carrier family 6 (neurotransmitter transporter), member 3 | SLC6A3 gene polymorphism results in increased susceptibility to Cocaine |
increases response to substance
|
gene |
8825631
|
| D003042 | 6532 |
SLC6A4
5-HTT 5-HTTLPR 5HTT HTT OCD1 SERT SERT1 hSERT |
solute carrier family 6 (neurotransmitter transporter), member 4 | Cocaine binds to and results in decreased activity of SLC6A4 protein |
affects binding
/ decreases activity |
protein |
16272152
|
| D003042 | 6532 |
SLC6A4
5-HTT 5-HTTLPR 5HTT HTT OCD1 SERT SERT1 hSERT |
solute carrier family 6 (neurotransmitter transporter), member 4 | Cocaine results in decreased activity of SLC6A4 protein |
decreases activity
|
protein |
18321529
|
| D003042 | 6532 |
SLC6A4
5-HTT 5-HTTLPR 5HTT HTT OCD1 SERT SERT1 hSERT |
solute carrier family 6 (neurotransmitter transporter), member 4 | Cocaine results in increased expression of SLC6A4 protein |
increases expression
|
protein |
11207425
|
| D003042 | 6549 |
SLC9A2
NHE2 |
solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 | Cocaine results in decreased expression of SLC9A2 mRNA |
decreases expression
|
mRNA |
18000554
|
| D003042 | 6622 |
SNCA
NACP PARK1 PARK4 PD1 |
synuclein, alpha (non A4 component of amyloid precursor) | Cocaine affects the expression of SNCA protein |
affects expression
|
protein |
19393250
|
| D003042 | 6622 |
SNCA
NACP PARK1 PARK4 PD1 |
synuclein, alpha (non A4 component of amyloid precursor) | Cocaine results in increased expression of SNCA mRNA |
increases expression
|
mRNA |
12684441
|
| D003042 | 6622 |
SNCA
NACP PARK1 PARK4 PD1 |
synuclein, alpha (non A4 component of amyloid precursor) | Cocaine results in increased expression of SNCA protein |
increases expression
|
protein |
12684441
16110277 18055133 |
| D003042 | 6647 |
SOD1
ALS ALS1 IPOA SOD hSod1 homodimer |
superoxide dismutase 1, soluble (EC:1.15.1.1) | Cocaine results in decreased expression of SOD1 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 6687 |
SPG7
CAR CMAR PGN SPG5C |
spastic paraplegia 7 (pure and complicated autosomal recessive) | Cocaine results in decreased expression of SPG7 mRNA |
decreases expression
|
mRNA |
18000554
|
| D003042 | 6711 |
SPTBN1
ELF SPTB2 betaSpII |
spectrin, beta, non-erythrocytic 1 | Cocaine results in decreased expression of SPTBN1 mRNA |
decreases expression
|
mRNA |
15009677
|
| D003042 | 6748 |
SSR4
TRAPD |
signal sequence receptor, delta | Cocaine results in decreased expression of SSR4 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 10402 |
ST3GAL6
SIAT10 ST3GALVI |
ST3 beta-galactoside alpha-2,3-sialyltransferase 6 (EC:2.4.99.-) | Cocaine results in increased expression of ST3GAL6 mRNA |
increases expression
|
mRNA |
12629581
|
| D003042 | 23208 |
SYT11
SYT12 sytXI |
synaptotagmin XI | Cocaine results in increased expression of SYT11 mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 57586 |
SYT13
|
synaptotagmin XIII | SYT13 gene SNP affects the susceptibility to Cocaine |
affects response to substance
|
gene |
18438686
|
| D003042 | 6870 |
TACR3
HH11 NK-3R NK3R NKR TAC3RL |
tachykinin receptor 3 | TACR3 SNP results in increased susceptibility to Cocaine |
increases response to substance
|
SNP |
18422838
|
| D003042 | 29114 |
TAGLN3
NP22 NP24 NP25 |
transgelin 3 | Cocaine results in decreased expression of TAGLN3 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 55714 |
TENM3
MCOPCB9 ODZ3 TNM3 Ten-m3 |
teneurin transmembrane protein 3 | TENM3 gene SNP affects the susceptibility to Cocaine |
affects response to substance
|
gene |
18438686
|
| D003042 | 7018 |
TF
PRO1557 PRO2086 TFQTL1 |
transferrin | Cocaine results in decreased expression of TF mRNA |
decreases expression
|
mRNA |
18357522
|
| D003042 | 7023 |
TFAP4
AP-4 bHLHc41 |
transcription factor AP-4 (activating enhancer binding protein 4) | Cocaine results in increased expression of TFAP4 mRNA |
increases expression
|
mRNA |
12629581
|
| D003042 | 7037 |
TFRC
CD71 T9 TFR TFR1 TR TRFR p90 |
transferrin receptor | Cocaine results in increased expression of TFRC mRNA |
increases expression
|
mRNA |
15009677
16710320 |
| D003042 | 261726 |
TIPRL
TIP TIP41 dJ69E11.3 |
TIP41, TOR signaling pathway regulator-like (S. cerevisiae) | Cocaine results in increased expression of TIPRL mRNA |
increases expression
|
mRNA |
18000554
|
| D003042 | 7086 |
TKT
TK TKT1 |
transketolase (EC:2.2.1.1) | Cocaine affects the expression of TKT protein |
affects expression
|
protein |
19393250
|
| D003042 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | [Cocaine co-treated with Heroin] results in increased expression of TNF protein |
affects cotreatment
/ increases expression |
protein |
16766138
|
| D003042 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | Cocaine results in decreased expression of TNF protein |
decreases expression
|
protein |
17068203
|
| D003042 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | Cocaine results in increased secretion of TNF protein |
increases secretion
|
protein |
10065903
|
| D003042 | 8764 |
TNFRSF14
ATAR CD270 HVEA HVEM LIGHTR TR2 |
tumor necrosis factor receptor superfamily, member 14 | Cocaine results in increased expression of TNFRSF14 mRNA |
increases expression
|
mRNA |
20948987
|
| D003042 | 7137 |
TNNI3
CMD1FF CMD2A CMH7 RCM1 TNNC1 cTnI |
troponin I type 3 (cardiac) | Cocaine results in increased secretion of TNNI3 protein |
increases secretion
|
protein |
12359538
|
| D003042 | 10140 |
TOB1
APRO6 PIG49 TOB TROB TROB1 |
transducer of ERBB2, 1 | Cocaine results in decreased expression of TOB1 mRNA |
decreases expression
|
mRNA |
15009677
|
| D003042 | 58476 |
TP53INP2
C20orf110 DOR PINH dJ1181N3.1 |
tumor protein p53 inducible nuclear protein 2 | Cocaine results in decreased expression of TP53INP2 mRNA |
decreases expression
|
mRNA |
15009677
|
| D003042 | 406303 | Cocaine results in decreased expression of TUBA2 mRNA |
decreases expression
|
mRNA |
12629581
|
||
| D003042 | 113457 |
TUBA3D
H2-ALPHA |
tubulin, alpha 3d | Cocaine results in decreased expression of TUBA3D mRNA |
decreases expression
|
mRNA |
20948987
|
| D003042 | 7277 |
TUBA4A
H2-ALPHA TUBA1 |
tubulin, alpha 4a | Cocaine results in decreased expression of TUBA4A mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 51807 |
TUBA8
TUBAL2 |
tubulin, alpha 8 | Cocaine results in decreased expression of TUBA8 mRNA |
decreases expression
|
mRNA |
20948987
|
| D003042 | 7297 |
TYK2
JTK1 |
tyrosine kinase 2 (EC:2.7.10.2) | TYK2 gene SNP affects the susceptibility to Cocaine |
affects response to substance
|
gene |
18438686
|
| D003042 | 7329 |
UBE2I
C358B7.1 P18 UBC9 |
ubiquitin-conjugating enzyme E2I (EC:6.3.2.19) | Cocaine results in increased expression of UBE2I mRNA |
increases expression
|
mRNA |
12629581
|
| D003042 | 9040 |
UBE2M
UBC-RS2 UBC12 hUbc12 |
ubiquitin-conjugating enzyme E2M (EC:6.3.2.19) | Cocaine results in decreased expression of UBE2M mRNA |
decreases expression
|
mRNA |
15009677
|
| D003042 | 7345 |
UCHL1
NDGOA PARK5 PGP_9.5 PGP9.5 PGP95 Uch-L1 |
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) (EC:3.4.19.12) | Cocaine results in decreased expression of UCHL1 mRNA |
decreases expression
|
mRNA |
12629581
|
| D003042 | 7357 |
UGCG
GCS GLCT1 |
UDP-glucose ceramide glucosyltransferase (EC:2.4.1.80) | Cocaine results in increased expression of UGCG mRNA |
increases expression
|
mRNA |
15009677
16710320 |
| D003042 | 7450 |
VWF
F8VWF VWD |
von Willebrand factor | Cocaine results in increased expression of VWF protein |
increases expression
|
protein |
10493323
11988210 |
| D003042 | 7531 |
YWHAE
14-3-3E KCIP-1 MDCR MDS |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | Cocaine results in increased expression of YWHAE mRNA |
increases expression
|
mRNA |
20948987
|
| D003042 | 7533 |
YWHAH
YWHA1 |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | Cocaine results in decreased expression of YWHAH mRNA |
decreases expression
|
mRNA |
12629581
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (6)
| OMIM | preferred title | UniProt |
|---|---|---|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
KEGG DISEASE (5)
| KEGG | disease name | UniProt |
|---|---|---|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|