PCIDB

KNApSAcK Metabolite C00023618

Metabolite

KNApSAcK Entry

id C00023618
Name Aflatoxin G1
CAS RN 1165-39-5
Standard InChI InChI=1S/C17H12O7/c1-20-9-6-10-12(8-3-5-22-17(8)23-10)14-11(9)7-2-4-21-15(18)13(7)16(19)24-14/h3,5-6,8,17H,2,4H2,1H3/t8-,17+/m0/s1
Standard InChI (Main Layer) InChI=1S/C17H12O7/c1-20-9-6-10-12(8-3-5-22-17(8)23-10)14-11(9)7-2-4-21-15(18)13(7)16(19)24-14/h3,5-6,8,17H,2,4H2,1H3

Cluster

Phytochemical cluster
KCF-S cluster No. 4719

Link

ChEMBL

By standard InChI
By standard InChI Main Layer

KEGG

By LinkDB C16755

CTD

By CAS RN C027955

Human Protein / Gene in interaction

CTD interaction (13)

compound gene gene name gene description interaction interaction type form reference
pmid
C027955 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) CYP1A2 protein results in increased susceptibility to aflatoxin G1 increases response to substance
protein 11189750
C027955 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) aflatoxin G1 promotes the reaction [NR1I2 protein binds to CYP3A4 promoter] affects binding
/ increases reaction
promoter 21641981
C027955 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) aflatoxin G1 results in increased expression of CYP3A4 mRNA increases expression
mRNA 21641981
C027955 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) CYP3A4 protein affects the metabolism of aflatoxin G1 affects metabolic processing
protein 2271712
2655891
C027955 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) CYP3A4 protein results in increased susceptibility to aflatoxin G1 increases response to substance
protein 11189750
C027955 1577 CYP3A5
CP35
CYPIIIA5
P450PCN3
PCN3
cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1) CYP3A5 protein results in increased susceptibility to aflatoxin G1 increases response to substance
protein 11189750
C027955 3105 HLA-A
HLAA
major histocompatibility complex, class I, A aflatoxin G1 results in decreased expression of HLA-A mRNA decreases expression
mRNA 20381597
C027955 3106 HLA-B
AS
HLAB
SPDA1
major histocompatibility complex, class I, B aflatoxin G1 results in decreased expression of HLA-B mRNA decreases expression
mRNA 20381597
C027955 8856 NR1I2
BXR
ONR1
PAR
PAR1
PAR2
PARq
PRR
PXR
SAR
SXR
nuclear receptor subfamily 1, group I, member 2 aflatoxin G1 promotes the reaction [NR1I2 protein binds to CYP3A4 promoter] affects binding
/ increases reaction
protein 21641981
C027955 8856 NR1I2
BXR
ONR1
PAR
PAR1
PAR2
PARq
PRR
PXR
SAR
SXR
nuclear receptor subfamily 1, group I, member 2 aflatoxin G1 results in increased activity of NR1I2 protein increases activity
protein 21641981
C027955 5698 PSMB9
LMP2
PSMB6i
RING12
beta1i
proteasome (prosome, macropain) subunit, beta type, 9 (EC:3.4.25.1) aflatoxin G1 results in decreased expression of PSMB9 protein decreases expression
protein 20381597
C027955 6890 TAP1
ABC17
ABCB2
APT1
D6S114E
PSF-1
PSF1
RING4
TAP1*0102N
TAP1N
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) aflatoxin G1 results in decreased expression of TAP1 mRNA decreases expression
mRNA 20381597
C027955 6890 TAP1
ABC17
ABCB2
APT1
D6S114E
PSF-1
PSF1
RING4
TAP1*0102N
TAP1N
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) aflatoxin G1 results in decreased expression of TAP1 protein decreases expression
protein 20381597