KNApSAcK Metabolite C00023620
Metabolite
KNApSAcK Entry
| id | C00023620 |
|---|---|
| Name | Aflatoxin M1 |
| CAS RN | 6795-23-9 |
| Standard InChI | InChI=1S/C17H12O7/c1-21-9-6-10-13(17(20)4-5-22-16(17)23-10)14-12(9)7-2-3-8(18)11(7)15(19)24-14/h4-6,16,20H,2-3H2,1H3/t16-,17-/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C17H12O7/c1-21-9-6-10-13(17(20)4-5-22-16(17)23-10)14-12(9)7-2-3-8(18)11(7)15(19)24-14/h4-6,16,20H,2-3H2,1H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 1313 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer |
KEGG
| By LinkDB | C16756 |
|---|
CTD
| By CAS RN | D016607 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Aspergillaceae | 2 |
List (2)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Aspergillus flavus NRRL 3251 | 5052 | Aspergillaceae | Fungi | |
| Aspergillus parasiticus | 5067 | Aspergillaceae | Fungi |
Human Protein / Gene in interaction
CTD interaction (6)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D016607 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | [CYP1A2 protein results in increased metabolism of Aflatoxin B1] which results in increased chemical synthesis of Aflatoxin M1 |
increases chemical synthesis
/ increases metabolic processing |
protein |
20707407
|
| D016607 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | Aflatoxin M1 promotes the reaction [NR1I2 protein binds to CYP3A4 promoter] |
affects binding
/ increases reaction |
promoter |
21641981
|
| D016607 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | Aflatoxin M1 results in increased expression of CYP3A4 mRNA |
increases expression
|
mRNA |
21641981
|
| D016607 | 27232 |
GNMT
|
glycine N-methyltransferase (EC:2.1.1.20) | GNMT results in increased secretion of Aflatoxin M1 |
increases secretion
|
19146867
|
|
| D016607 | 8856 |
NR1I2
BXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR |
nuclear receptor subfamily 1, group I, member 2 | Aflatoxin M1 promotes the reaction [NR1I2 protein binds to CYP3A4 promoter] |
affects binding
/ increases reaction |
protein |
21641981
|
| D016607 | 8856 |
NR1I2
BXR ONR1 PAR PAR1 PAR2 PARq PRR PXR SAR SXR |
nuclear receptor subfamily 1, group I, member 2 | Aflatoxin M1 results in increased activity of NR1I2 protein |
increases activity
|
protein |
21641981
|