PCIDB

KNApSAcK Metabolite C00023743

Metabolite

KNApSAcK Entry

id C00023743
Name Desmosterol / 24-Dehydrocholesterol / Cholesta-5,24-dien-3beta-ol
CAS RN 313-04-2
Standard InChI InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
Standard InChI (Main Layer) InChI=1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,9,19,21-25,28H,6,8,10-17H2,1-5H3

Cluster

Phytochemical cluster No. 11
KCF-S cluster No. 53

Link

ChEMBL

By standard InChI CHEMBL455876
By standard InChI Main Layer CHEMBL455876

KEGG

By LinkDB C01802

CTD

By CAS RN D003897

Human Protein / Gene in interaction

CTD interaction (3)

compound gene gene name gene description interaction interaction type form reference
pmid
D003897 1593 CYP27A1
CP27
CTX
CYP27
cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) CYP27A1 protein results in increased metabolism of Desmosterol increases metabolic processing
protein 14622972
D003897 1718 DHCR24
DCE
Nbla03646
SELADIN1
seladin-1
24-dehydrocholesterol reductase (EC:1.3.1.72) DHCR24 protein results in increased metabolism of Desmosterol increases metabolic processing
protein 23042211
D003897 1718 DHCR24
DCE
Nbla03646
SELADIN1
seladin-1
24-dehydrocholesterol reductase (EC:1.3.1.72) [DHCR24 protein results in increased metabolism of Desmosterol] which results in increased abundance of Cholesterol increases abundance
/ increases metabolic processing
protein 23042211

Related Disease

Diseases related to CTD interactions

2 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000544 D003897 Alzheimer Disease marker/mechanism
23042211
D009135 D003897 Muscular Diseases marker/mechanism
729726