KNApSAcK Metabolite C00002457
Metabolite
KNApSAcK Entry
| id | C00002457 |
|---|---|
| Name | Chartreusin |
| CAS RN | 6377-18-0 |
| Standard InChI | InChI=1S/C32H32O14/c1-10-8-9-15-18-16(10)29(38)45-26-17-13(23(35)20(19(18)26)30(39)43-15)6-5-7-14(17)44-32-28(24(36)21(33)11(2)42-32)46-31-25(37)27(40-4)22(34)12(3)41-31/h5-9,11-12,21-22,24-25,27-28,31-37H,1-4H3/t11?,12?,21-,22-,24-,25+,27?,28?,31+,32-/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C32H32O14/c1-10-8-9-15-18-16(10)29(38)45-26-17-13(23(35)20(19(18)26)30(39)43-15)6-5-7-14(17)44-32-28(24(36)21(33)11(2)42-32)46-31-25(37)27(40-4)22(34)12(3)41-31/h5-9,11-12,21-22,24-25,27-28,31-37H,1-4H3 |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 2687 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL357992 CHEMBL1159640 CHEMBL1414149 CHEMBL1554674 |
KEGG
| By LinkDB | C09181 |
|---|
CTD
| By CAS RN | C002185 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Streptomycetaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Streptomyces chartreusis | 1969 | Streptomycetaceae | Bacteria |
Human Protein / Gene in interaction
21 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL1414149 |
CHEMBL1741321
(1)
|
1 / 0 |
| P29466 | Caspase-1 | C14 | CHEMBL1414149 |
CHEMBL1614158
(1)
|
0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | CHEMBL357992 |
CHEMBL1794585
(1)
|
0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL1414149 |
CHEMBL1741325
(1)
|
0 / 1 |
| P39748 | Flap endonuclease 1 | Enzyme | CHEMBL357992 CHEMBL1554674 |
CHEMBL1794486
(2)
|
0 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL357992 |
CHEMBL2114843
(1)
CHEMBL2114780
(1)
|
0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | CHEMBL357992 |
CHEMBL2114807
(1)
|
4 / 2 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | CHEMBL357992 |
CHEMBL2114788
(1)
|
0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | CHEMBL357992 |
CHEMBL1794569
(1)
|
1 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL1554674 |
CHEMBL1794401
(1)
|
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL1414149 |
CHEMBL1741322
(1)
|
0 / 0 |
| P55210 | Caspase-7 | C14 | CHEMBL1414149 |
CHEMBL1613779
(1)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL1414149 |
CHEMBL1741323
(1)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL1414149 |
CHEMBL1741324
(1)
|
0 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | CHEMBL357992 CHEMBL1554674 |
CHEMBL1794483
(2)
|
0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL357992 CHEMBL1554674 |
CHEMBL1738184
(2)
|
0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | CHEMBL357992 CHEMBL1554674 |
CHEMBL1794536
(2)
|
0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | CHEMBL357992 |
CHEMBL2354311
(1)
|
1 / 0 |
| O00255 | Menin | Unclassified protein | CHEMBL1554674 |
CHEMBL1614531
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL1554674 |
CHEMBL1614531
(1)
|
1 / 3 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | CHEMBL357992 |
CHEMBL2114796
(1)
|
2 / 1 |
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (13)
| OMIM | preferred title | UniProt |
|---|---|---|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #114500 | Colorectal cancer; crc |
Q14191
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (14)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00027 | Ovarian cancer |
P38398
(related)
|
| H00031 | Breast cancer |
P38398
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00296 | Defects in RecQ helicases |
Q14191
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|