PCIDB

KNApSAcK Metabolite C00002465

Metabolite

KNApSAcK Entry

id C00002465
Name Decursin
CAS RN 5928-25-6
Standard InChI InChI=1S/C19H20O5/c1-11(2)7-18(21)23-16-9-13-8-12-5-6-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/t16-/m0/s1
Standard InChI (Main Layer) InChI=1S/C19H20O5/c1-11(2)7-18(21)23-16-9-13-8-12-5-6-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3

Cluster

Phytochemical cluster No. 25
KCF-S cluster No. 858

Link

ChEMBL

By standard InChI CHEMBL481658
By standard InChI Main Layer CHEMBL481658 CHEMBL1715398

KEGG

By LinkDB C09258

CTD

By CAS RN C101278

Species

Summary

Plant class

class name count
asterids 2

Family

family name count
Apiaceae 2

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Angelica decursiva 52491 Apiaceae asterids Viridiplantae
Angelica gigas 85712 Apiaceae asterids Viridiplantae

Human Protein / Gene in interaction

7 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P08047 Transcription factor Sp1 Unclassified protein CHEMBL481658 CHEMBL1058704 (1)
0 / 0
P56817 Beta-secretase 1 A1A CHEMBL481658 CHEMBL1936881 (1) CHEMBL1936882 (1)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL1715398 CHEMBL1738588 (1)
0 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL481658 CHEMBL1003053 (1)
1 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL1715398 CHEMBL1738184 (1)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL1715398 CHEMBL2354311 (1)
1 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL1715398 CHEMBL2354287 (1)
1 / 1

CTD interaction (7)

compound gene gene name gene description interaction interaction type form reference
pmid
C101278 367 AR
AIS
DHTR
HUMARA
HYSP1
KD
NR3C4
SBMA
SMAX1
TFM
androgen receptor benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [decursin results in increased degradation of AR protein] decreases reaction
/ increases degradation
protein 17723170
C101278 367 AR
AIS
DHTR
HUMARA
HYSP1
KD
NR3C4
SBMA
SMAX1
TFM
androgen receptor decursin results in decreased localization of and results in decreased expression of AR protein decreases expression
/ decreases localization
protein 17723170
C101278 367 AR
AIS
DHTR
HUMARA
HYSP1
KD
NR3C4
SBMA
SMAX1
TFM
androgen receptor decursin results in increased degradation of AR protein increases degradation
protein 17723170
C101278 354 KLK3
APS
KLK2A1
PSA
hK3
kallikrein-related peptidase 3 (EC:3.4.21.77) decursin results in decreased expression of and results in decreased secretion of KLK3 protein decreases expression
/ decreases secretion
protein 17723170
C101278 354 KLK3
APS
KLK2A1
PSA
hK3
kallikrein-related peptidase 3 (EC:3.4.21.77) decursin results in decreased expression of KLK3 mRNA decreases expression
mRNA 17723170
C101278 354 KLK3
APS
KLK2A1
PSA
hK3
kallikrein-related peptidase 3 (EC:3.4.21.77) decursin results in decreased secretion of KLK3 protein decreases secretion
protein 17723170
C101278 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) decursin results in increased cleavage of PARP1 protein increases cleavage
protein 17723170

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (3)

OMIM preferred title UniProt
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#137800 Glioma susceptibility 1; glm1 O75874
#112100 Yt blood group antigen P22303

KEGG DISEASE (1)

KEGG disease name UniProt
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000647 C101278 Amnesia therapeutic
12482674