PCIDB

KNApSAcK Metabolite C00002467

Metabolite

KNApSAcK Entry

id C00002467
Name Dicoumarol
CAS RN 66-76-2
Standard InChI InChI=1S/C19H12O6/c20-16-10-5-1-3-7-14(10)24-18(22)12(16)9-13-17(21)11-6-2-4-8-15(11)25-19(13)23/h1-8,20-21H,9H2
Standard InChI (Main Layer) InChI=1S/C19H12O6/c20-16-10-5-1-3-7-14(10)24-18(22)12(16)9-13-17(21)11-6-2-4-8-15(11)25-19(13)23/h1-8,20-21H,9H2

Cluster

Phytochemical cluster No. 25
KCF-S cluster No. 1906

Link

ChEMBL

By standard InChI CHEMBL1466
By standard InChI Main Layer CHEMBL1466

KEGG

By LinkDB C00796

CTD

By CAS RN D001728

Species

Summary

Plant class

class name count
Liliopsida 1
rosids 1

Family

family name count
Poaceae 1
Fabaceae 1

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Anthoxanthum spp. 15324 Poaceae Liliopsida Viridiplantae
Melilotus spp. 47081 Fabaceae rosids Viridiplantae

Human Protein / Gene in interaction

100 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1466 CHEMBL1741321 (1) CHEMBL1909136 (2)
1 / 0
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL1466 CHEMBL1613992 (1) CHEMBL1613995 (1)
7 / 44
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL1466 CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL1466 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL1466 CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL1466 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL1466 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL1466 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL1466 CHEMBL1909176 (2)
0 / 0
P29466 Caspase-1 C14 CHEMBL1466 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL1466 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL1466 CHEMBL1909199 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL1466 CHEMBL1909197 (2)
2 / 2
P02545 Prelamin-A/C Unclassified protein CHEMBL1466 CHEMBL1614544 (1)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL1466 CHEMBL1614361 (1)
3 / 2
P00918 Carbonic anhydrase 2 Lyase CHEMBL1466 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL1466 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL1466 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL1466 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL1466 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL1466 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL1466 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL1466 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL1466 CHEMBL1909093 (2)
0 / 0
P02768 Serum albumin Secreted protein CHEMBL1466 CHEMBL1805606 (1) CHEMBL1805607 (1)
CHEMBL1805608 (1) CHEMBL1805609 (1)
0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL1466 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL1466 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL1466 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1466 CHEMBL1614027 (1) CHEMBL1741325 (1)
CHEMBL1909135 (2)
0 / 1
P15559 NAD(P)H dehydrogenase [quinone] 1 Enzyme CHEMBL1466 CHEMBL911952 (1) CHEMBL901432 (1)
CHEMBL901433 (1) CHEMBL1045769 (1)
CHEMBL1045770 (1)
0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL1466 CHEMBL1909203 (2)
1 / 11
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL1466 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL1466 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL1466 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL1466 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL1466 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL1466 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL1466 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL1466 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL1466 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL1466 CHEMBL1909166 (2)
1 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL1466 CHEMBL1614458 (1)
0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL1466 CHEMBL1909133 (2)
0 / 0
O75496 Geminin Unclassified protein CHEMBL1466 CHEMBL2114780 (1)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL1466 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL1466 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL1466 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL1466 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL1466 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL1466 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL1466 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL1466 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL1466 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL1466 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL1466 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL1466 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL1466 CHEMBL1909194 (2)
0 / 0
Q16549 Proprotein convertase subtilisin/kexin type 7 S8B CHEMBL1466 CHEMBL1815481 (1)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL1466 CHEMBL1909110 (2)
1 / 0
P03956 Interstitial collagenase M10A CHEMBL1466 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL1466 CHEMBL1909119 (2)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL1466 CHEMBL1794467 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL1466 CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL1466 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL1466 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL1466 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL1466 CHEMBL1909109 (2)
2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL1466 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL1466 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL1466 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL1466 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL1466 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL1466 CHEMBL1909108 (2)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL1466 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL1466 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL1466 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1466 CHEMBL1741322 (1) CHEMBL1909132 (2)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL1466 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL1466 CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL1466 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL1466 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL1466 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL1466 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL1466 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL1466 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL1466 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL1466 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL1466 CHEMBL1909168 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1466 CHEMBL1613777 (1) CHEMBL1741323 (1)
CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1466 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (1) CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL1466 CHEMBL1909137 (2)
0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL1466 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL1466 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL1466 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL1466 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL1466 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL1466 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL1466 CHEMBL1909128 (2)
0 / 0
O00255 Menin Unclassified protein CHEMBL1466 CHEMBL1614257 (1) CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL1466 CHEMBL1614257 (1) CHEMBL1614531 (1)
1 / 3

CTD interaction (62)

compound gene gene name gene description interaction interaction type form reference
pmid
D001728 213 ALB
PRO0883
PRO0903
PRO1341
albumin Dicumarol binds to ALB protein affects binding
protein 62049
D001728 847 CAT
catalase (EC:1.11.1.6) CAT protein results in decreased susceptibility to Dicumarol decreases response to substance
protein 17040906
D001728 942 CD86
B7-2
B7.2
B70
CD28LG2
LAB72
CD86 molecule [Dicumarol results in decreased activity of NQO1 protein] inhibits the reaction [Eugenol results in increased expression of CD86 protein] decreases activity
/ decreases reaction
/ increases expression
protein 21742781
D001728 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Dicumarol inhibits the reaction [diaziquone results in increased expression of CDKN1A mRNA] decreases reaction
/ increases expression
mRNA 9343371
D001728 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Dicumarol inhibits the reaction [RB1CC1 protein results in increased expression of CDKN1A protein] decreases reaction
/ increases expression
protein 16061648
D001728 1050 CEBPA
C/EBP-alpha
CEBP
CCAAT/enhancer binding protein (C/EBP), alpha Dicumarol inhibits the reaction [NQO1 protein binds to CEBPA protein] affects binding
/ decreases reaction
protein 23086932
D001728 3309 HSPA5
BIP
GRP78
MIF2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Dicumarol inhibits the reaction [1-nitropyrene results in increased expression of HSPA5 protein] decreases reaction
/ increases expression
protein 19460413
D001728 3479 IGF1
IGF-I
IGF1A
IGFI
insulin-like growth factor 1 (somatomedin C) Dicumarol inhibits the reaction [IGF1 protein results in increased activity of JNK protein] decreases reaction
/ increases activity
protein 11278392
D001728 3479 IGF1
IGF-I
IGF1A
IGFI
insulin-like growth factor 1 (somatomedin C) Dicumarol inhibits the reaction [IGF1 protein results in increased phosphorylation of JUN protein] decreases reaction
/ increases phosphorylation
protein 11278392
D001728 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Dicumarol inhibits the reaction [IL1B protein results in increased expression of TP53 protein] decreases reaction
/ increases expression
protein 17959154
D001728 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Dicumarol inhibits the reaction [Ozone results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 19059883
D001728 100533320 Dicumarol inhibits the reaction [IGF1 protein results in increased activity of JNK protein] decreases reaction
/ increases activity
protein 11278392
D001728 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Dicumarol inhibits the reaction [IGF1 protein results in increased phosphorylation of JUN protein] decreases reaction
/ increases phosphorylation
protein 11278392
D001728 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein] decreases reaction
/ increases phosphorylation
protein 17669387
D001728 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 17669387
D001728 5602 MAPK10
JNK3
JNK3A
PRKM10
SAPK1b
p493F12
p54bSAPK
mitogen-activated protein kinase 10 (EC:2.7.11.24) Dicumarol inhibits the reaction [Anisomycin results in increased activity of MAPK10 protein] decreases reaction
/ increases activity
protein 10531305
D001728 5602 MAPK10
JNK3
JNK3A
PRKM10
SAPK1b
p493F12
p54bSAPK
mitogen-activated protein kinase 10 (EC:2.7.11.24) Dicumarol inhibits the reaction [Sorbitol results in increased activity of MAPK10 protein] decreases reaction
/ increases activity
protein 10531305
D001728 5602 MAPK10
JNK3
JNK3A
PRKM10
SAPK1b
p493F12
p54bSAPK
mitogen-activated protein kinase 10 (EC:2.7.11.24) Dicumarol inhibits the reaction [TRAF2 protein results in increased activity of MAPK10 protein] decreases reaction
/ increases activity
protein 10531305
D001728 5602 MAPK10
JNK3
JNK3A
PRKM10
SAPK1b
p493F12
p54bSAPK
mitogen-activated protein kinase 10 (EC:2.7.11.24) Dicumarol results in decreased activity of MAPK10 protein decreases activity
protein 10531305
D001728 5602 MAPK10
JNK3
JNK3A
PRKM10
SAPK1b
p493F12
p54bSAPK
mitogen-activated protein kinase 10 (EC:2.7.11.24) NQO1 protein inhibits the reaction [Dicumarol results in decreased activity of MAPK10 protein] decreases activity
/ decreases reaction
protein 10531305
D001728 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 17669387
D001728 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Dicumarol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein] decreases reaction
/ increases expression
/ increases secretion
protein 17669387
D001728 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Dicumarol inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA] decreases reaction
/ increases expression
mRNA 17669387
D001728 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) hydroquinone inhibits the reaction [Dicumarol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]] decreases reaction
/ increases expression
/ increases secretion
protein 17669387
D001728 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Dicumarol inhibits the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein] decreases reaction
/ increases activity
protein 10531305
D001728 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Dicumarol inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] decreases reaction
/ increases activity
protein 10531305
D001728 1728 NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) Dicumarol inhibits the reaction [[arsenite results in increased expression of NQO1 protein] which results in increased susceptibility to Mitomycin] decreases reaction
/ increases expression
/ increases response to substance
protein 16494910
D001728 1728 NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) Dicumarol inhibits the reaction [NQO1 protein binds to CEBPA protein] affects binding
/ decreases reaction
protein 23086932
D001728 1728 NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) Dicumarol inhibits the reaction [NQO1 protein results in decreased susceptibility to arsenite] decreases reaction
/ decreases response to substance
protein 16494910
D001728 1728 NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) Dicumarol inhibits the reaction [NQO1 protein results in increased metabolism of Mitomycin] decreases reaction
/ increases metabolic processing
protein 1701346
D001728 1728 NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) Dicumarol inhibits the reaction [TP53 protein binds to NQO1 protein] affects binding
/ decreases reaction
protein 14634213
D001728 1728 NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) Dicumarol results in decreased activity of NQO1 protein decreases activity
protein 8572925
11154737
15805261
17669387
D001728 1728 NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) [Dicumarol results in decreased activity of NQO1 protein] inhibits the reaction [Eugenol results in increased expression of CD86 protein] decreases activity
/ decreases reaction
/ increases expression
protein 21742781
D001728 1728 NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) [Dicumarol results in decreased activity of NQO1 protein] which results in decreased activity of diaziquone decreases activity
protein 2113030
D001728 1728 NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) [Dicumarol results in decreased activity of NQO1 protein] which results in decreased susceptibility to Mitomycin decreases activity
/ decreases response to substance
protein 15655414
D001728 1728 NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) [Dicumarol results in decreased activity of NQO1 protein] which results in decreased susceptibility to Streptonigrin decreases activity
/ decreases response to substance
protein 15655414
D001728 1728 NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) Dicumarol results in decreased expression of NQO1 protein decreases expression
protein 17979524
D001728 1728 NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) NQO1 protein affects the susceptibility to Dicumarol affects response to substance
protein 10531305
D001728 1728 NQO1
DHQU
DIA4
DTD
NMOR1
NMORI
QR1
NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) NQO1 protein inhibits the reaction [Dicumarol results in decreased activity of MAPK10 protein] decreases activity
/ decreases reaction
protein 10531305
D001728 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 Dicumarol results in increased phosphorylation of RB1 protein increases phosphorylation
protein 15896341
D001728 9821 RB1CC1
CC1
FIP200
RB1-inducible coiled-coil 1 Dicumarol inhibits the reaction [RB1CC1 protein results in increased expression of CDKN1A protein] decreases reaction
/ increases expression
protein 16061648
D001728 9821 RB1CC1
CC1
FIP200
RB1-inducible coiled-coil 1 Dicumarol inhibits the reaction [RB1CC1 protein results in increased expression of TP53 protein] decreases reaction
/ increases expression
protein 16061648
D001728 9821 RB1CC1
CC1
FIP200
RB1-inducible coiled-coil 1 Dicumarol inhibits the reaction [RB1CC1 protein results in increased stability of TP53 protein] decreases reaction
/ increases stability
protein 16061648
D001728 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Dicumarol inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein] decreases reaction
/ increases activity
protein 10531305
D001728 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Dicumarol inhibits the reaction [TNF protein affects the localization of RELA protein] affects localization
/ decreases reaction
protein 17669387
D001728 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Dicumarol inhibits the reaction [TNF protein results in increased activity of RELA protein] decreases reaction
/ increases activity
protein 10531305
D001728 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) SOD2 protein results in decreased susceptibility to Dicumarol decreases response to substance
protein 17040906
D001728 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Dicumarol inhibits the reaction [TNF protein affects the localization of RELA protein] affects localization
/ decreases reaction
protein 17669387
D001728 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Dicumarol inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] decreases reaction
/ increases activity
protein 10531305
D001728 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Dicumarol inhibits the reaction [TNF protein results in increased activity of RELA protein] decreases reaction
/ increases activity
protein 10531305
D001728 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Dicumarol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein] decreases reaction
/ increases expression
/ increases secretion
protein 17669387
D001728 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Dicumarol inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA] decreases reaction
/ increases expression
protein 17669387
D001728 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of JUN protein] decreases reaction
/ increases phosphorylation
protein 17669387
D001728 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 17669387
D001728 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Dicumarol inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 17669387
D001728 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor hydroquinone inhibits the reaction [Dicumarol inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]] decreases reaction
/ increases expression
/ increases secretion
protein 17669387
D001728 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Dicumarol inhibits the reaction [IL1B protein results in increased expression of TP53 protein] decreases reaction
/ increases expression
protein 17959154
D001728 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Dicumarol inhibits the reaction [RB1CC1 protein results in increased expression of TP53 protein] decreases reaction
/ increases expression
protein 16061648
D001728 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Dicumarol inhibits the reaction [RB1CC1 protein results in increased stability of TP53 protein] decreases reaction
/ increases stability
protein 16061648
D001728 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Dicumarol inhibits the reaction [TP53 protein binds to NQO1 protein] affects binding
/ decreases reaction
protein 14634213
D001728 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Dicumarol results in increased degradation of TP53 protein increases degradation
protein 14634213
D001728 7186 TRAF2
MGC:45012
TRAP
TRAP3
TNF receptor-associated factor 2 Dicumarol inhibits the reaction [TRAF2 protein results in increased activity of MAPK10 protein] decreases reaction
/ increases activity
protein 10531305

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (59)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260500 Papilloma of choroid plexus; cpp P04637
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (72)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)

Diseases related to CTD interactions

24 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D001766 D001728 Blindness marker/mechanism
4112318
D001943 D001728 Breast Neoplasms therapeutic
17040906
D002305 D001728 Cardiac Tamponade marker/mechanism
6184935
D002543 D001728 Cerebral Hemorrhage marker/mechanism
54935
1374271
D002779 D001728 Cholestasis marker/mechanism
9548270
D003085 D001728 Colic marker/mechanism
4173338
D015715 D001728 Corneal Edema marker/mechanism
4112318
D003967 D001728 Diarrhea marker/mechanism
4173338
D058447 D001728 Eye Pain marker/mechanism
4112318
D006417 D001728 Hematuria marker/mechanism
4171018
D006470 D001728 Hemorrhage marker/mechanism
4112318
D020300 D001728 Intracranial Hemorrhages marker/mechanism
59801
D007674 D001728 Kidney Diseases marker/mechanism
therapeutic
4171018
21613233
D017114 D001728 Liver Failure, Acute marker/mechanism
9548270
D008545 D001728 Melanoma therapeutic
20685355
D009203 D001728 Myocardial Infarction therapeutic
4173338
D009798 D001728 Ocular Hypertension marker/mechanism
4112318
D010190 D001728 Pancreatic Neoplasms therapeutic
15240547
17040906
D010490 D001728 Pericardial Effusion marker/mechanism
6184935
D011183 D001728 Postoperative Complications therapeutic
54935
D011655 D001728 Pulmonary Embolism therapeutic
4112318
D020521 D001728 Stroke marker/mechanism
59801
D013923 D001728 Thromboembolism therapeutic
54935
D013927 D001728 Thrombosis therapeutic
10831996