PCIDB

KNApSAcK Metabolite C00002530

Metabolite

KNApSAcK Entry

id C00002530
Name (-)-Glyceollin I
CAS RN 57103-57-8
Standard InChI InChI=1S/C20H18O5/c1-19(2)8-7-12-15(25-19)6-4-13-17(12)23-10-20(22)14-5-3-11(21)9-16(14)24-18(13)20/h3-9,18,21-22H,10H2,1-2H3/t18-,20+/m0/s1
Standard InChI (Main Layer) InChI=1S/C20H18O5/c1-19(2)8-7-12-15(25-19)6-4-13-17(12)23-10-20(22)14-5-3-11(21)9-16(14)24-18(13)20/h3-9,18,21-22H,10H2,1-2H3

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 325

Link

ChEMBL

By standard InChI CHEMBL1774987
By standard InChI Main Layer CHEMBL1774987 CHEMBL1774988 CHEMBL1774989

KEGG

By LinkDB C01701

CTD

By CAS RN C017343

Human Protein / Gene in interaction

CTD interaction (9)

compound gene gene name gene description interaction interaction type form reference
pmid
C017343 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 glyceollin binds to ESR1 protein affects binding
protein 19797619
C017343 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 glyceollin inhibits the reaction [Estradiol binds to ESR1 protein] affects binding
/ decreases reaction
protein 19797619
C017343 4804 NGFR
CD271
Gp80-LNGFR
TNFRSF16
p75(NTR)
p75NTR
nerve growth factor receptor glyceollin results in increased expression of NGFR mRNA increases expression
mRNA 19797619
C017343 5241 PGR
NR3C3
PR
progesterone receptor glyceollin inhibits the reaction [Estradiol results in increased expression of PGR mRNA] decreases reaction
/ increases expression
mRNA 19797619
C017343 5241 PGR
NR3C3
PR
progesterone receptor glyceollin inhibits the reaction [Estrogens results in increased expression of PGR mRNA] decreases reaction
/ increases expression
mRNA 19797619
C017343 5241 PGR
NR3C3
PR
progesterone receptor [Tamoxifen co-treated with glyceollin] results in decreased expression of PGR mRNA affects cotreatment
/ decreases expression
mRNA 19797619
C017343 100195758 glyceollin inhibits the reaction [Estradiol results in increased expression of SDF1 mRNA] decreases reaction
/ increases expression
mRNA 19797619
C017343 100195758 glyceollin inhibits the reaction [Estrogens results in increased expression of SDF1 mRNA] decreases reaction
/ increases expression
mRNA 19797619
C017343 100195758 [Tamoxifen co-treated with glyceollin] results in decreased expression of SDF1 mRNA affects cotreatment
/ decreases expression
mRNA 19797619