id | C00002641 |
---|---|
Name | Cannabidiol |
CAS RN | 13956-29-1 |
Standard InChI | InChI=1S/C21H30O2/c1-5-6-7-8-16-12-19(22)21(20(23)13-16)18-11-15(4)9-10-17(18)14(2)3/h11-13,17-18,22-23H,2,5-10H2,1,3-4H3/t17-,18+/m0/s1 |
Standard InChI (Main Layer) | InChI=1S/C21H30O2/c1-5-6-7-8-16-12-19(22)21(20(23)13-16)18-11-15(4)9-10-17(18)14(2)3/h11-13,17-18,22-23H,2,5-10H2,1,3-4H3 |
Phytochemical cluster | No. 66 |
---|---|
KCF-S cluster | No. 5008 |
By standard InChI | CHEMBL190461 |
---|---|
By standard InChI Main Layer | CHEMBL76762 CHEMBL190461 CHEMBL236171 |
By LinkDB | C07578 |
---|
By CAS RN | D002185 |
---|
class name | count |
---|---|
rosids | 1 |
family name | count |
---|---|
Cannabaceae | 1 |
KNApSAcK organism | *ID | *family | *plant class | *kingdom |
---|---|---|---|---|
Cannabis sativa var. indica | 3482 | Cannabaceae | rosids | Viridiplantae |
accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
---|---|---|---|---|---|
P34972 | Cannabinoid receptor 2 | Cannabinoid receptor | CHEMBL76762 CHEMBL190461 CHEMBL236171 |
CHEMBL658964
(1)
CHEMBL768189
(1)
CHEMBL925156 (2) CHEMBL1117767 (1) |
0 / 0 |
Q9Y2T6 | G-protein coupled receptor 55 | Lysophosphatidylinositol receptor | CHEMBL190461 |
CHEMBL1117885
(1)
|
0 / 0 |
P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | CHEMBL76762 CHEMBL190461 CHEMBL236171 |
CHEMBL858761
(1)
CHEMBL768189
(1)
CHEMBL901108 (1) CHEMBL925155 (2) CHEMBL1117766 (1) |
0 / 0 |
compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
---|---|---|---|---|---|---|---|
D002185 | 1268 |
CNR1
CANN6 CB-R CB1 CB1A CB1K5 CB1R CNR |
cannabinoid receptor 1 (brain) | CNR1 protein promotes the reaction [Cannabidiol results in decreased secretion of SERPINE1 protein] |
decreases secretion
/ increases reaction |
protein |
20668920
|
D002185 | 1269 |
CNR2
CB-2 CB2 CX5 |
cannabinoid receptor 2 (macrophage) | CNR2 protein promotes the reaction [Cannabidiol results in decreased secretion of SERPINE1 protein] |
decreases secretion
/ increases reaction |
protein |
20668920
|
D002185 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cannabidiol results in increased expression of ICAM1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
22198381
|
D002185 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | AM 251 inhibits the reaction [Cannabidiol results in increased expression of ICAM1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
22198381
|
D002185 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | Cannabidiol results in increased expression of ICAM1 mRNA |
increases expression
|
mRNA |
22198381
|
D002185 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | Cannabidiol results in increased expression of ICAM1 protein |
increases expression
|
protein |
22198381
|
D002185 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | capsazepine inhibits the reaction [Cannabidiol results in increased expression of ICAM1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
22198381
|
D002185 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | ICAM1 mutant form inhibits the reaction [Cannabidiol results in increased expression of TIMP1 protein] |
decreases reaction
/ increases expression |
mutant form |
22198381
|
D002185 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | iodopravadoline inhibits the reaction [Cannabidiol results in increased expression of ICAM1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
22198381
|
D002185 | 3620 |
IDO1
IDO IDO-1 INDO |
indoleamine 2,3-dioxygenase 1 (EC:1.13.11.52) | AM 281 promotes the reaction [Cannabidiol inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]] |
decreases reaction
/ increases activity / increases reaction |
protein |
19167098
|
D002185 | 3620 |
IDO1
IDO IDO-1 INDO |
indoleamine 2,3-dioxygenase 1 (EC:1.13.11.52) | Cannabidiol inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein] |
decreases reaction
/ increases activity |
protein |
19167098
|
D002185 | 3620 |
IDO1
IDO IDO-1 INDO |
indoleamine 2,3-dioxygenase 1 (EC:1.13.11.52) | Cannabidiol inhibits the reaction [[Plant Preparations results in increased activity of IDO1 protein] which results in increased abundance of Neopterin] |
decreases reaction
/ increases abundance / increases activity |
protein |
19167098
|
D002185 | 3620 |
IDO1
IDO IDO-1 INDO |
indoleamine 2,3-dioxygenase 1 (EC:1.13.11.52) | Cannabidiol inhibits the reaction [Plant Preparations results in increased expression of IDO1 mRNA] |
decreases reaction
/ increases expression |
mRNA |
19167098
|
D002185 | 3620 |
IDO1
IDO IDO-1 INDO |
indoleamine 2,3-dioxygenase 1 (EC:1.13.11.52) | iodopravadoline promotes the reaction [Cannabidiol inhibits the reaction [Plant Preparations results in increased activity of IDO1 protein]] |
decreases reaction
/ increases activity / increases reaction |
protein |
19167098
|
D002185 | 3458 |
IFNG
IFG IFI |
interferon, gamma | Cannabidiol affects the reaction [Plant Preparations results in increased secretion of IFNG protein] |
affects reaction
/ increases secretion |
protein |
19167098
|
D002185 | 3458 |
IFNG
IFG IFI |
interferon, gamma | Cannabidiol inhibits the reaction [Plant Preparations results in increased expression of IFNG mRNA] |
decreases reaction
/ increases expression |
mRNA |
19167098
|
D002185 | 5054 |
SERPINE1
PAI PAI-1 PAI1 PLANH1 |
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | Cannabidiol results in decreased expression of SERPINE1 mRNA |
decreases expression
|
mRNA |
20668920
|
D002185 | 5054 |
SERPINE1
PAI PAI-1 PAI1 PLANH1 |
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | Cannabidiol results in decreased secretion of SERPINE1 protein |
decreases secretion
|
protein |
20668920
|
D002185 | 5054 |
SERPINE1
PAI PAI-1 PAI1 PLANH1 |
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | CNR1 protein promotes the reaction [Cannabidiol results in decreased secretion of SERPINE1 protein] |
decreases secretion
/ increases reaction |
protein |
20668920
|
D002185 | 5054 |
SERPINE1
PAI PAI-1 PAI1 PLANH1 |
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | CNR2 protein promotes the reaction [Cannabidiol results in decreased secretion of SERPINE1 protein] |
decreases secretion
/ increases reaction |
protein |
20668920
|
D002185 | 5054 |
SERPINE1
PAI PAI-1 PAI1 PLANH1 |
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | SERPINE1 protein results in increased susceptibility to Cannabidiol |
increases response to substance
|
protein |
20668920
|
D002185 | 5054 |
SERPINE1
PAI PAI-1 PAI1 PLANH1 |
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | TRPV1 protein promotes the reaction [Cannabidiol results in decreased secretion of SERPINE1 protein] |
decreases secretion
/ increases reaction |
protein |
20668920
|
D002185 | 7076 |
TIMP1
CLGI EPA EPO HCI TIMP |
TIMP metallopeptidase inhibitor 1 | Cannabidiol results in increased expression of TIMP1 mRNA |
increases expression
|
mRNA |
22198381
|
D002185 | 7076 |
TIMP1
CLGI EPA EPO HCI TIMP |
TIMP metallopeptidase inhibitor 1 | Cannabidiol results in increased expression of TIMP1 protein |
increases expression
|
protein |
22198381
|
D002185 | 7076 |
TIMP1
CLGI EPA EPO HCI TIMP |
TIMP metallopeptidase inhibitor 1 | ICAM1 mutant form inhibits the reaction [Cannabidiol results in increased expression of TIMP1 protein] |
decreases reaction
/ increases expression |
protein |
22198381
|
D002185 | 7442 |
TRPV1
VR1 |
transient receptor potential cation channel, subfamily V, member 1 | Cannabidiol inhibits the reaction [Capsaicin binds to TRPV1 protein] |
affects binding
/ decreases reaction |
protein |
11606325
|
D002185 | 7442 |
TRPV1
VR1 |
transient receptor potential cation channel, subfamily V, member 1 | Cannabidiol inhibits the reaction [[Capsaicin binds to TRPV1 protein] which results in increased uptake of Calcium] |
affects binding
/ decreases reaction / increases uptake |
protein |
11606325
|
D002185 | 7442 |
TRPV1
VR1 |
transient receptor potential cation channel, subfamily V, member 1 | Cannabidiol inhibits the reaction [resiniferatoxin binds to TRPV1 protein] |
affects binding
/ decreases reaction |
protein |
11606325
|
D002185 | 7442 |
TRPV1
VR1 |
transient receptor potential cation channel, subfamily V, member 1 | Cannabidiol inhibits the reaction [[resiniferatoxin binds to TRPV1 protein] which results in increased uptake of Calcium] |
affects binding
/ decreases reaction / increases uptake |
protein |
11606325
|
D002185 | 7442 |
TRPV1
VR1 |
transient receptor potential cation channel, subfamily V, member 1 | Cannabidiol results in increased activity of TRPV1 protein |
increases activity
|
protein |
11606325
|
D002185 | 7442 |
TRPV1
VR1 |
transient receptor potential cation channel, subfamily V, member 1 | [Cannabidiol results in increased activity of TRPV1 protein] which results in increased uptake of Calcium |
increases activity
/ increases uptake |
protein |
11606325
|
D002185 | 7442 |
TRPV1
VR1 |
transient receptor potential cation channel, subfamily V, member 1 | capsazepine inhibits the reaction [Cannabidiol results in increased activity of TRPV1 protein] |
decreases reaction
/ increases activity |
protein |
11606325
|
D002185 | 7442 |
TRPV1
VR1 |
transient receptor potential cation channel, subfamily V, member 1 | capsazepine inhibits the reaction [[Cannabidiol results in increased activity of TRPV1 protein] which results in increased uptake of Calcium] |
decreases reaction
/ increases activity / increases uptake |
protein |
11606325
|
D002185 | 7442 |
TRPV1
VR1 |
transient receptor potential cation channel, subfamily V, member 1 | TRPV1 protein promotes the reaction [Cannabidiol results in decreased secretion of SERPINE1 protein] |
decreases secretion
/ increases reaction |
protein |
20668920
|
D002185 | 51393 |
TRPV2
VRL VRL-1 VRL1 |
transient receptor potential cation channel, subfamily V, member 2 | Cannabidiol results in increased activity of TRPV2 protein |
increases activity
|
protein |
18550765
|
MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
---|---|---|---|---|---|
D001714 | D002185 | Bipolar Disorder |
therapeutic
|
19939866
|
|
D003072 | D002185 | Cognition Disorders |
therapeutic
|
21350020
|
|
D004421 | D002185 | Dystonia |
therapeutic
|
3793381
|
|
D007022 | D002185 | Hypotension |
marker/mechanism
|
3793381
10570211 |
|
D008569 | D002185 | Memory Disorders |
marker/mechanism
|
16406104
|
|
D009325 | D002185 | Nausea |
therapeutic
|
21827451
|
|
D009362 | D002185 | Neoplasm Metastasis |
therapeutic
|
22198381
|
|
D011605 | D002185 | Psychoses, Substance-Induced |
therapeutic
|
16612464
|
|
D012559 | D002185 | Schizophrenia |
therapeutic
|
16612464
|
|
D012640 | D002185 | Seizures |
marker/mechanism
therapeutic |
841172
10605059 |
|
D014839 | D002185 | Vomiting |
therapeutic
|
21827451
|
|
D014987 | D002185 | Xerostomia |
marker/mechanism
|
3793381
|