PCIDB

KNApSAcK Metabolite C00026628

Metabolite

KNApSAcK Entry

id C00026628
Name Chetomin
CAS RN 1403-36-7
Standard InChI InChI=1S/C31H30N6O6S4/c1-33-25(42)30(15-38)34(2)23(40)28(33,44-46-30)12-17-13-36(21-11-7-4-8-18(17)21)27-14-29-24(41)35(3)31(16-39,47-45-29)26(43)37(29)22(27)32-20-10-6-5-9-19(20)27/h4-11,13,22,32,38-39H,12,14-16H2,1-3H3/t22-,27+,28+,29+,30+,31+/m1/s1
Standard InChI (Main Layer) InChI=1S/C31H30N6O6S4/c1-33-25(42)30(15-38)34(2)23(40)28(33,44-46-30)12-17-13-36(21-11-7-4-8-18(17)21)27-14-29-24(41)35(3)31(16-39,47-45-29)26(43)37(29)22(27)32-20-10-6-5-9-19(20)27/h4-11,13,22,32,38-39H,12,14-16H2,1-3H3

Cluster

Phytochemical cluster
KCF-S cluster No. 2768

Link

ChEMBL

By standard InChI CHEMBL499593
By standard InChI Main Layer CHEMBL499593 CHEMBL1965934

KEGG

By LinkDB

CTD

By CAS RN C001598

Species

Summary

Plant class

class name count

Family

family name count
Chaetomiaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Chaetomium seminudum 5149 Chaetomiaceae Fungi

Human Protein / Gene in interaction

2 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
O43463 Histone-lysine N-methyltransferase SUV39H1 Enzyme CHEMBL499593 CHEMBL2173370 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL499593 CHEMBL2173371 (1)
0 / 0

CTD interaction (8)

compound gene gene name gene description interaction interaction type form reference
pmid
C001598 1906 EDN1
ET1
HDLCQ7
PPET1
endothelin 1 chetomin inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 mRNA] decreases reaction
/ increases expression
mRNA 21926265
C001598 1906 EDN1
ET1
HDLCQ7
PPET1
endothelin 1 chetomin inhibits the reaction [Oxygen deficiency results in increased expression of EDN1 protein] decreases reaction
/ increases expression
protein 21926265
C001598 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) chetomin inhibits the reaction [HIF1A protein promotes the reaction [Lipopolysaccharides results in increased expression of VEGFA protein]] decreases reaction
/ increases expression
/ increases reaction
protein 19744167
C001598 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) chetomin inhibits the reaction [HIF1A protein promotes the reaction [TNF protein results in decreased metabolism of Oxygen]] decreases metabolic processing
/ decreases reaction
/ increases reaction
protein 19744167
C001598 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) chetomin results in decreased expression of HIF1A mRNA decreases expression
mRNA 19744167
C001598 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor chetomin inhibits the reaction [HIF1A protein promotes the reaction [TNF protein results in decreased metabolism of Oxygen]] decreases metabolic processing
/ decreases reaction
/ increases reaction
protein 19744167
C001598 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A chetomin inhibits the reaction [aristolochic acid I results in increased expression of VEGFA protein] decreases reaction
/ increases expression
protein 21554934
C001598 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A chetomin inhibits the reaction [HIF1A protein promotes the reaction [Lipopolysaccharides results in increased expression of VEGFA protein]] decreases reaction
/ increases expression
/ increases reaction
protein 19744167