KNApSAcK Metabolite C00027872
Metabolite
KNApSAcK Entry
| id | C00027872 |
|---|---|
| Name | Ansamycin |
| CAS RN | 72559-06-9 |
| Standard InChI | InChI=1S/C46H62N4O11/c1-12-24(4)50-19-17-46(18-20-50)48-34-31-32-39(54)28(8)42-33(31)43(56)45(10,61-42)59-21-16-30(58-11)25(5)41(60-29(9)51)27(7)38(53)26(6)37(52)22(2)14-13-15-23(3)44(57)47-36(40(32)55)35(34)49-46/h13-16,21-22,24-27,30,37-38,41,49,52-54H,12,17-20H2,1-11H3,(H,47,57)/b14-13+,21-16+,23-15+/t22-,24?,25+,26+,27+,30-,37-,38+,41+,45-/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C46H62N4O11/c1-12-24(4)50-19-17-46(18-20-50)48-34-31-32-39(54)28(8)42-33(31)43(56)45(10,61-42)59-21-16-30(58-11)25(5)41(60-29(9)51)27(7)38(53)26(6)37(52)22(2)14-13-15-23(3)44(57)47-36(40(32)55)35(34)49-46/h13-16,21-22,24-27,30,37-38,41,49,52-54H,12,17-20H2,1-11H3,(H,47,57) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 5656 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer |
KEGG
| By LinkDB | C07235 |
|---|
CTD
| By CAS RN | D017828 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Streptomycetaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Streptomyces sp. USF-319 | 1883 | Streptomycetaceae | Bacteria |
Human Protein / Gene in interaction
CTD interaction (10)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D017828 | 13 |
AADAC
CES5A1 DAC |
arylacetamide deacetylase (EC:3.1.1.3) | AADAC mRNA affects the reaction [Rifabutin results in increased expression of CYP3A4 mRNA] |
affects reaction
/ increases expression |
mRNA |
21856291
|
| D017828 | 13 |
AADAC
CES5A1 DAC |
arylacetamide deacetylase (EC:3.1.1.3) | AADAC protein results in decreased acetylation of Rifabutin |
decreases acetylation
|
protein |
21856291
|
| D017828 | 13 |
AADAC
CES5A1 DAC |
arylacetamide deacetylase (EC:3.1.1.3) | bis(4-nitrophenyl)phosphate inhibits the reaction [AADAC protein results in decreased acetylation of Rifabutin] |
decreases acetylation
/ decreases reaction |
protein |
21856291
|
| D017828 | 13 |
AADAC
CES5A1 DAC |
arylacetamide deacetylase (EC:3.1.1.3) | Isoflurophate inhibits the reaction [AADAC protein results in decreased acetylation of Rifabutin] |
decreases acetylation
/ decreases reaction |
protein |
21856291
|
| D017828 | 13 |
AADAC
CES5A1 DAC |
arylacetamide deacetylase (EC:3.1.1.3) | Phenylmethylsulfonyl Fluoride inhibits the reaction [AADAC protein results in decreased acetylation of Rifabutin] |
decreases acetylation
/ decreases reaction |
protein |
21856291
|
| D017828 | 13 |
AADAC
CES5A1 DAC |
arylacetamide deacetylase (EC:3.1.1.3) | Physostigmine inhibits the reaction [AADAC protein results in decreased acetylation of Rifabutin] |
decreases acetylation
/ decreases reaction |
protein |
21856291
|
| D017828 | 13 |
AADAC
CES5A1 DAC |
arylacetamide deacetylase (EC:3.1.1.3) | Sodium Fluoride inhibits the reaction [AADAC protein results in decreased acetylation of Rifabutin] |
decreases acetylation
/ decreases reaction |
protein |
21856291
|
| D017828 | 8647 |
ABCB11
ABC16 BRIC2 BSEP PFIC-2 PFIC2 PGY4 SPGP |
ATP-binding cassette, sub-family B (MDR/TAP), member 11 | Rifabutin results in decreased activity of ABCB11 protein |
decreases activity
|
protein |
20829430
|
| D017828 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | AADAC mRNA affects the reaction [Rifabutin results in increased expression of CYP3A4 mRNA] |
affects reaction
/ increases expression |
mRNA |
21856291
|
| D017828 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | Rifabutin results in increased expression of CYP3A4 mRNA |
increases expression
|
mRNA |
16837568
21856291 |
Related Disease
Diseases related to CTD interactions
8 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D000163 | D017828 | Acquired Immunodeficiency Syndrome |
therapeutic
|
9101573
|
|
| D007177 | D017828 | Inappropriate ADH Syndrome |
marker/mechanism
|
11310523
|
|
| D007970 | D017828 | Leukopenia |
marker/mechanism
|
11310523
|
|
| D015270 | D017828 | Mycobacterium avium-intracellulare Infection |
therapeutic
|
11310523
|
|
| D015864 | D017828 | Panuveitis |
marker/mechanism
|
16321897
|
|
| D031300 | D017828 | Retinal Vasculitis |
marker/mechanism
|
9101573
16321897 |
|
| D014397 | D017828 | Tuberculosis, Pulmonary |
therapeutic
|
16321897
|
|
| D014605 | D017828 | Uveitis |
marker/mechanism
|
9101573
|