PCIDB

KNApSAcK Metabolite C00003013

Metabolite

KNApSAcK Entry

id C00003013
Name Purpurogallin
CAS RN 569-77-7
Standard InChI InChI=1S/C11H8O5/c12-6-3-1-2-5-4-7(13)10(15)11(16)8(5)9(6)14/h1-4,13,15-16H,(H,12,14)
Standard InChI (Main Layer) InChI=1S/C11H8O5/c12-6-3-1-2-5-4-7(13)10(15)11(16)8(5)9(6)14/h1-4,13,15-16H,(H,12,14)

Cluster

Phytochemical cluster
KCF-S cluster No. 8679

Link

ChEMBL

By standard InChI CHEMBL66953
By standard InChI Main Layer CHEMBL66953

KEGG

By LinkDB C09964

CTD

By CAS RN C026133

Species

Summary

Plant class

class name count
rosids 1

Family

family name count
Fagaceae 1

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Dryophanta divisa
Quercus pedunculanta 3511 Fagaceae rosids Viridiplantae

Human Protein / Gene in interaction

52 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL66953 CHEMBL1613992 (1) CHEMBL1613995 (1)
7 / 44
Q07820 Induced myeloid leukemia cell differentiation protein Mcl-1 Other cytosolic protein CHEMBL66953 CHEMBL1614529 (1)
0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL66953 CHEMBL1738312 (1)
0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL66953 CHEMBL1794499 (1)
2 / 0
P14618 Pyruvate kinase PKM Enzyme CHEMBL66953 CHEMBL1613996 (1) CHEMBL1614428 (1)
0 / 0
P06746 DNA polymerase beta Enzyme CHEMBL66953 CHEMBL1614079 (1)
0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL66953 CHEMBL1614076 (1)
1 / 1
P04406 Glyceraldehyde-3-phosphate dehydrogenase Enzyme CHEMBL66953 CHEMBL1613955 (1)
0 / 0
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL66953 CHEMBL1613776 (1)
3 / 1
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr CHEMBL66953 CHEMBL1613889 (1) CHEMBL1614401 (1)
0 / 0
Q00535 Cyclin-dependent kinase 5 Cdk5 CHEMBL66953 CHEMBL1738240 (1)
0 / 0
Q15078 Cyclin-dependent kinase 5 activator 1 REG serine/threonine protein kinase family CHEMBL66953 CHEMBL1738240 (1)
0 / 0
P54132 Bloom syndrome protein Enzyme CHEMBL66953 CHEMBL1614067 (2)
1 / 2
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL66953 CHEMBL1614166 (1)
1 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL66953 CHEMBL1794311 (1)
2 / 3
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL66953 CHEMBL1614458 (2)
0 / 0
P16581 E-selectin Adhesion CHEMBL66953 CHEMBL917094 (1)
0 / 0
P68871 Hemoglobin subunit beta Secreted protein CHEMBL66953 CHEMBL1613976 (1)
4 / 4
P39748 Flap endonuclease 1 Enzyme CHEMBL66953 CHEMBL1794486 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL66953 CHEMBL1738606 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL66953 CHEMBL1794584 (1)
2 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein CHEMBL66953 CHEMBL1614280 (1)
0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL66953 CHEMBL1614257 (1) CHEMBL1614410 (1)
1 / 3
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL66953 CHEMBL1794401 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL66953 CHEMBL1794467 (1)
0 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL66953 CHEMBL1614521 (1) CHEMBL1613808 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL66953 CHEMBL1613910 (1)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL66953 CHEMBL1614038 (1)
2 / 2
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL66953 CHEMBL1614240 (1)
0 / 0
P14151 L-selectin Adhesion CHEMBL66953 CHEMBL917098 (1)
0 / 0
P16109 P-selectin Adhesion CHEMBL66953 CHEMBL917096 (1)
1 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL66953 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL66953 CHEMBL1794483 (1)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL66953 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL66953 CHEMBL1614466 (1) CHEMBL1614211 (2)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL66953 CHEMBL1614250 (2) CHEMBL1614421 (2)
CHEMBL1614502 (2)
4 / 3
P11940 Polyadenylate-binding protein 1 Unclassified protein CHEMBL66953 CHEMBL1963883 (1) CHEMBL1963941 (1)
0 / 0
Q07817 Bcl-2-like protein 1 Other cytosolic protein CHEMBL66953 CHEMBL647263 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL66953 CHEMBL1794536 (2)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL66953 CHEMBL1613914 (2)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL66953 CHEMBL1613829 (2)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL66953 CHEMBL1738442 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL66953 CHEMBL1614364 (2)
1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL66953 CHEMBL2354311 (1)
1 / 0
O00255 Menin Unclassified protein CHEMBL66953 CHEMBL1614257 (1)
2 / 5
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL66953 CHEMBL1738090 (2) CHEMBL1737904 (2)
CHEMBL1738444 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL66953 CHEMBL1738090 (2) CHEMBL1737904 (2)
CHEMBL1738444 (1)
1 / 6
P19429 Troponin I, cardiac muscle Unclassified protein CHEMBL66953 CHEMBL1738244 (1)
4 / 4
P45379 Troponin T, cardiac muscle Unclassified protein CHEMBL66953 CHEMBL1738244 (1)
3 / 5
P63316 Troponin C, slow skeletal and cardiac muscles Other cytosolic protein CHEMBL66953 CHEMBL1738244 (1)
2 / 2
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL66953 CHEMBL2114738 (1)
0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme CHEMBL66953 CHEMBL2114796 (1)
2 / 1

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (49)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#613985 Beta-thalassemia P68871
#603902 Beta-thalassemia, dominant inclusion body type P68871
#210900 Bloom syndrome; blm P54132
#601494 Cardiomyopathy, dilated, 1d; cmd1d P45379
#613286 Cardiomyopathy, dilated, 1ff; cmd1ff P19429
#611879 Cardiomyopathy, dilated, 1z; cmd1z P63316
#611880 Cardiomyopathy, dilated, 2a; cmd2a P19429
#613243 Cardiomyopathy, familial hypertrophic, 13; cmh13 P63316
#115195 Cardiomyopathy, familial hypertrophic, 2; cmh2 P45379
#613690 Cardiomyopathy, familial hypertrophic, 7; cmh7 P19429
#115210 Cardiomyopathy, familial restrictive, 1; rcm1 P19429
#612422 Cardiomyopathy, familial restrictive, 3; rcm3 P45379
#114500 Colorectal cancer; crc P84022
Q14191
#119900 Digital clubbing, isolated congenital P15428
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#140700 Heinz body anemias P68871
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P04637
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#603903 Sickle cell anemia P68871
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P16109
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191

KEGG DISEASE (68)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
P68871 (marker)
H00022 Bladder cancer P04637 (related)
P68871 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00292 Hypertrophic cardiomyopathy (HCM) P19429 (related)
P45379 (related)
P63316 (related)
H00294 Dilated cardiomyopathy (DCM) P19429 (related)
P45379 (related)
P63316 (related)
H01219 Restrictive cardiomyopathy (RCM) P19429 (related)
P45379 (related)
H00295 Viral myocarditis P19429 (marker)
P45379 (marker)
H01216 Left ventricular noncompaction (LVNC) P45379 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00228 Thalassemia P68871 (related)
H00229 Sickle cell anemia (SCA) P68871 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)